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    FTO FTO alpha-ketoglutarate dependent dioxygenase [ Homo sapiens (human) ]

    Gene ID: 79068, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes.

    Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes.
    Słomiński B, Skrzypkowska M, Myśliwiec M, Trzonkowski P.

    06/7/2024
    Fat mass and obesity-associated protein (FTO) mediated m[6]A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.

    Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.
    Wu X, Fang Y, Gu Y, Shen H, Xu Y, Xu T, Shi R, Xu D, Zhang J, Leng K, Shu Y, Ma P., Free PMC Article

    06/5/2024
    FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.

    FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.
    Yin Z, Guo X, Liang X, Wang Z.

    05/22/2024
    FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.

    FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.
    Huang Q, Sun Y, Huang W, Zhang F, He H, He Y, Huang F., Free PMC Article

    05/13/2024
    FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3.

    FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3.
    Xie W, Shao Y, Bo Q, Li Z, Yu Q, Wang L, Wu G.

    04/25/2024
    FTO protein regulates the TGF-beta signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion.

    FTO protein regulates the TGF-β signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion.
    Zhang J, Liu X, Gao Y.

    04/15/2024
    circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis.

    circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis.
    Liu Q, Xu P, Jin M, Wang L, Hu F, Yang Q, Bi R, Xiao H, Jiang L, Ding F., Free PMC Article

    04/4/2024
    MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.

    MicroRNA-192-5p downregulates Fat Mass and Obesity-associated Protein to aggravate renal ischemia/reperfusion injury.
    Zhang C, Guan G, Wang J, Wei H, Cai J., Free PMC Article

    04/3/2024
    Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes.

    Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes.
    Roumi Z, Salimi Z, Mahmoudi Z, Mobarakeh KA, Ladaninezhad M, Zeinalabedini M, Keshavarz Mohammadian M, Shamsi-Goushki A, Saeedirad Z, Bahar B, Khoshdooz S, Kalantari N, Azizi Tabesh G, Doaei S, Gholamalizadeh M., Free PMC Article

    04/2/2024
    The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico.

    The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico.
    Arellano-Pérez-Vertti RD, González-Galarza FF, Prone-Olazábal D, Arellano-Ramírez DO, Arellano-Ramírez DF, Argüello-Beltrán CS, Tovar-Aguilar MA, Berúmen-Rodríguez M, Prieto-Hinojosa AI, Méndez-Hernández A, Argüello-Astorga R.

    03/14/2024
    The m[6]A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.

    The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.
    He Y, Chen Y, Li Z, Wu C., Free PMC Article

    02/27/2024
    Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: A nano-based investigation.

    Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: A nano-based investigation.
    Kou R, Li T, Fu C, Jiang D, Wang Y, Meng J, Zhong R, Liang C, Dong M.

    02/22/2024
    Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity.

    Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity.
    Mosaad YM, Morzak M, Abd El Aziz El Chennawi F, Elsharkawy AA, Abdelsalam M.

    02/14/2024
    Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and beta-cell function: In vitro studies using INS-1 cells and human pancreatic islets.

    Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets.
    Taneera J, Khalique A, Abdrabh S, Mohammed AK, Bouzid A, El-Huneidi W, Bustanji Y, Sulaiman N, Albasha S, Saber-Ayad M, Hamad M.

    02/12/2024
    FTO is a major genetic link between breast cancer, obesity, and diabetes.

    FTO is a major genetic link between breast cancer, obesity, and diabetes.
    Gholami M.

    01/29/2024
    RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer.

    RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer.
    Lai Y, Dong H, Xu P, Wang J, Feng W, Zhao Z, Sha L., Free PMC Article

    01/16/2024
    Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.

    Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.
    Ma Y, Zhang X, Xuan B, Li D, Yin N, Ning L, Zhou YL, Yan Y, Tong T, Zhu X, Huang X, Hu M, Wang Z, Cui Z, Li H, Wang J, Fang JY, Liu R, Chen H, Hong J.

    01/9/2024
    FTO genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults.

    FTO genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults.
    Madrigal-Juarez A, Martínez-López E, Sanchez-Murguia T, Magaña-de la Vega L, Rodriguez-Echevarria R, Sepulveda-Villegas M, Torres-Valadez R, Torres-Castillo N.

    01/6/2024
    Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.

    Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.
    Yu Y, Liang C, Tang Q, Shi Y, Shen L.

    01/5/2024
    Minor alleles of FTO rs9939609 and rs17817449 polymorphisms confer a higher risk of type 2 diabetes mellitus and dyslipidemia, but not coronary artery disease in a Chinese Han population.

    Minor alleles of FTO rs9939609 and rs17817449 polymorphisms confer a higher risk of type 2 diabetes mellitus and dyslipidemia, but not coronary artery disease in a Chinese Han population.
    Zhang Y, Chen L, Zhu J, Liu H, Xu L, Wu Y, He C, Song Y., Free PMC Article

    01/3/2024
    FTO variation and early frontostriatal brain development in children.

    FTO variation and early frontostriatal brain development in children.
    Thapaliya G, Kundu P, Jansen E, Naymik MA, Lee R, Bruchhage MMK, D'Sa V, Huentelman MJ, Lewis CR, Müller HG, Deoni SCL, RESONANCE consortium, Carnell S.,

    01/3/2024
    Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis.

    Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis.
    Xu Y, Wang L, Qian R, Zhao M, Chen X, Sun D, Wang Y, Cheng W, Chen Y, He Q, Dai Y, Yao Y.

    12/21/2023
    FTO up-regulation induced by MYC suppresses tumour progression in Epstein-Barr virus-associated gastric cancer.

    FTO up-regulation induced by MYC suppresses tumour progression in Epstein-Barr virus-associated gastric cancer.
    Xu YY, Li T, Shen A, Bao XQ, Lin JF, Guo LZ, Meng Q, Ruan DY, Zhang QH, Zuo ZX, Zeng ZL., Free PMC Article

    12/20/2023
    Type 2 diabetes linked FTO gene variant rs8050136 is significantly associated with gravidity in gestational diabetes in a sample of Bangladeshi women: Meta-analysis and case-control study.

    Type 2 diabetes linked FTO gene variant rs8050136 is significantly associated with gravidity in gestational diabetes in a sample of Bangladeshi women: Meta-analysis and case-control study.
    Amin USM, Rahman TA, Hasan M, Tofail T, Hasanat MA, Seraj ZI, Salimullah M., Free PMC Article

    12/5/2023
    N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.

    N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
    Jing YX, Li HX, Yue F, Li YM, Yu X, He JJ, Zhang XH.

    11/28/2023
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