| Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2. | Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2.
Ezine E, Lebbe C, Dumaz N., Free PMC Article | 11/1/2023 |
| Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D., Free PMC Article | 10/15/2022 |
| RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. | RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F., Free PMC Article | 12/18/2021 |
| G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity. | G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity.
Feng G, Cai J, Huang Y, Zhu X, Gong B, Yang Z, Yan C, Hu Z, Yang L, Wang Z. | 10/2/2021 |
| Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant. | Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant.
Huang L, Xu W, Yan D, You X, Shi X, Zhang S, Hong H, Dai L. | 01/2/2021 |
| Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and androgen receptor signaling cascades. | Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades.
Huang Y, Feng G, Cai J, Peng Q, Yang Z, Yan C, Yang L, Wang Z. | 03/28/2020 |
| Sin1 is an amplifier of platelet alphaIIbbeta3-mediated outsidein signaling and a susceptible sensor of hypoxia/ROS signaling in ischemic environments after myocardial infarction, inducing microthrombosis. | Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets.
Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J. | 08/3/2019 |
| Lysophosphatidic acids tabilizes mSin1 protein expression via JNK signaling by blocking its proteasomal degradation and identify the LPA/JNK/mSin1/mTORC/collagen I pathway as critical for fibrotic activation of mesenchymal cells. | c-Jun N-terminal kinase (JNK)-mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis.
Walker NM, Mazzoni SM, Vittal R, Fingar DC, Lama VN., Free PMC Article | 06/1/2019 |
| SIN1 interacted and co-located with PKC zeta by pleckstrin homology (PH) domain. Downregulation of SIN1 severely impaired PKC zeta translocation and phosphorylation induced by insulin. | The Effect of SIN1 and Microtubules on Insulin Induced PKC ζ Activation.
Yingying X, Caijuan W, Yenan Y, Yuqin T, Xueqin C, Zhongming W., Free PMC Article | 05/5/2018 |
| SIN1 plays an important role in breast cancer. | SIN1 promotes the proliferation and migration of breast cancer cells by Akt activation.
Wang D, Wu P, Wang H, Zhu L, Zhao W, Lu Y., Free PMC Article | 12/9/2017 |
| In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer. | Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.
Wang Q, Zhu J, Wang YW, Dai Y, Wang YL, Wang C, Liu J, Baker A, Colburn NH, Yang HS., Free PMC Article | 12/2/2017 |
| SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC | Epigenetic activation of SIN1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition.
Hu Z, Wang Y, Wang Y, Zang B, Hui H, You Z, Wang X. | 06/10/2017 |
| This study provides evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for Interferon-gamma-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. | Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.
Kroczynska B, Blyth GT, Rafidi RL, Majchrzak-Kita B, Xu L, Saleiro D, Kosciuczuk EM, Jemielity J, Su B, Altman JK, Eklund EA, Fish EN, Platanias LC., Free PMC Article | 06/10/2017 |
| Intracellular localization of mTORC2 component, mSin1, contributes to regulation of Akt phosphorylation. | Localization of mTORC2 activity inside cells.
Ebner M, Sinkovics B, Szczygieł M, Ribeiro DW, Yudushkin I., Free PMC Article | 06/3/2017 |
| Akt phosphorylates SIN1 at T86, enhancing mTORC2 kinase activity, which leads to phosphorylation of Akt S473 by mTORC2, thereby catalyzing full activation of Akt. | A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
Yang G, Murashige DS, Humphrey SJ, James DE. | 05/28/2016 |
| MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica. | MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica.
Zhu X, Zhang J, Fan W, Gong Y, Yan J, Yuan Z, Wu L, Cui H, Luo H, Kong Q, Tang L, Leng S, Liao Y, Fu W, Xiao Q, Li D., Free PMC Article | 12/19/2015 |
| mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma. | 9q33.3, a stress-related chromosome region, contributes to reducing lung squamous cell carcinoma risk.
Xiao Q, Gao S, Luo H, Fan W, Guo S, Yao H, Leng S, Xu Z, Tao T, Liu X, Jingfang Z, Zhang M, Li D, Xiao Q. | 02/14/2015 |
| DNA-PKcs-mTORC2(SIN1) association is required for UVB-induced Akt Ser-473 phosphorylation and cell survival. | DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.
Tu Y, Ji C, Yang B, Yang Z, Gu H, Lu CC, Wang R, Su ZL, Chen B, Sun WL, Xia JP, Bi ZG, He L., Free PMC Article | 07/12/2014 |
| Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient lymphangioleiomyomatosis cells. | Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J, Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, Israel E, Xu KF, Henske EP, Blenis J, Levy BD, Kwiatkowski D, Yu JJ., Free PMC Article | 03/15/2014 |
| results reveal a Sin1-phosphorylation-dependent mTORC2 regulation, providing a potential molecular mechanism by which mutations in the mTORC1-S6K-Sin1 signalling axis might cause aberrant hyper-activation of the mTORC2-Akt pathway | Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W., Free PMC Article | 01/18/2014 |
| NBS1 interacts with the mTOR/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt activity. | Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
Wang JQ, Chen JH, Chen YC, Chen MY, Hsieh CY, Teng SC, Wu KJ., Free PMC Article | 01/18/2014 |
| SIN1 plays an important role in hepatocellular carcinoma invasion and metastasis by facilitating epithelial-mesenchymal transition. | SIN1 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition.
Xu J, Li X, Yang H, Chang R, Kong C, Yang L. | 08/31/2013 |
| structures show that the C-termini of Avo1 and Sin1 both have the pleckstrin homology (PH) domain fold | Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
Pan D, Matsuura Y., Free PMC Article | 06/30/2012 |
| mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel | mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
Lu M, Wang J, Ives HE, Pearce D., Free PMC Article | 10/29/2011 |
| There is an increased mitochondrial dependence upon mTORC2 dependent cell growth due to PTEN loss | Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.
Colombi M, Molle KD, Benjamin D, Rattenbacher-Kiser K, Schaefer C, Betz C, Thiemeyer A, Regenass U, Hall MN, Moroni C. | 01/27/2011 |