| Role of Swiprosin-1/EFHD2 as a biomarker in the development of chronic diseases. | Role of Swiprosin-1/EFHD2 as a biomarker in the development of chronic diseases.
Thylur Puttalingaiah R. | 04/16/2022 |
| EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis. | EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis.
Fan CC, Tsai ST, Lin CY, Chang LC, Yang JC, Chen GY, Sher YP, Wang SC, Hsiao M, Chang WC., Free PMC Article | 07/31/2021 |
| Association between EFHD2 gene polymorphisms and schizophrenia among the Han population in northern China. | Association between EFHD2 gene polymorphisms and schizophrenia among the Han population in northern China.
Gao M, Zeng K, Li Y, Liu YP, Xia X, Xu FL, Yao J, Wang BJ., Free PMC Article | 04/17/2021 |
| our study uncovers a protein complex, which consists of SWS1, SWSAP1, SPIDR and PDS5B, involved in DNA repair and provides insight into Shu complex function and composition | The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.
Martino J, Brunette GJ, Barroso-González J, Moiseeva TN, Smith CM, Bakkenist CJ, O'Sullivan RJ, Bernstein KA., Free PMC Article | 12/14/2019 |
| first time we have identified the -100/+41 to -70/+41 bp core promoter regions of Swiprosin-1 gene, and showed ADR1 and Sp1 are important transcription factors that directly bind to and transactivate the Swiprosin-1 promoter region. | Conserved Noncoding Sequences Boost ADR1 and SP1 Regulated Human Swiprosin-1 Promoter Activity.
Thylur RP, Ahn SY, Jung E, Jun CD, Hyun YM., Free PMC Article | 10/26/2019 |
| EFHD2 was identified as expressed in highly metastatic tumor cells. EFHD2 increased the formation of protrusive invadopodia structures and cell migration and invasion abilities and promoted the epithelial-to-mesenchymal transition (EMT) character of lung adenocarcinoma cells. We demonstrated that the mechanism of EFHD2 in enhancing EMT occurs partly through inhibition of caveolin-1 (CAV1) for cancer progression. | EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma.
Fan CC, Cheng WC, Huang YC, Sher YP, Liou NJ, Chien YC, Lin PS, Lin PS, Chen CH, Chang WC., Free PMC Article | 08/3/2019 |
| EFHD2 is an important regulator of T cell cytotoxicity and further studies should evaluate its role in T cell-mediated inflammation | EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity.
Peled M, Dragovich MA, Adam K, Strazza M, Tocheva AS, Vega IE, Mor A., Free PMC Article | 07/20/2019 |
| MOES, ANXA5 and EFHD2 were confirmed by selected reaction monitoring to be correlated to monocytic differentiation, and could be biomarkers for disease stratification in AML | Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia.
Forthun RB, Aasebø E, Rasinger JD, Bedringaas SL, Berven F, Selheim F, Bruserud Ø, Gjertsen BT. | 07/13/2019 |
| Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2+. The core region of EFhd2 maintains its structure in the absence of Ca2+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2. | Structural implications of Ca(2+)-dependent actin-bundling function of human EFhd2/Swiprosin-1.
Park KR, Kwon MS, An JY, Lee JG, Youn HS, Lee Y, Kang JY, Kim TG, Lim JJ, Park JS, Lee SH, Song WK, Cheong HK, Jun CD, Eom SH., Free PMC Article | 06/23/2018 |
| Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure. | Structural mechanism underlying regulation of human EFhd2/Swiprosin-1 actin-bundling activity by Ser183 phosphorylation.
Park KR, An JY, Kang JY, Lee JG, Lee Y, Mun SA, Jun CD, Song WK, Eom SH. | 06/24/2017 |
| The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state. | Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity.
Vázquez-Rosa E, Rodríguez-Cruz EN, Serrano S, Rodríguez-Laureano L, Vega IE., Free PMC Article | 04/25/2015 |
| EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia. | The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.
Borger E, Herrmann A, Mann DA, Spires-Jones T, Gunn-Moore F., Free PMC Article | 01/31/2015 |
| Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity. | Swiprosin-1 is a novel actin bundling protein that regulates cell spreading and migration.
Kwon MS, Park KR, Kim YD, Na BR, Kim HR, Choi HJ, Piragyte I, Jeon H, Chung KH, Song WK, Eom SH, Jun CD., Free PMC Article | 04/12/2014 |
| Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183 | Swiprosin-1 modulates actin dynamics by regulating the F-actin accessibility to cofilin.
Huh YH, Kim SH, Chung KH, Oh S, Kwon MS, Choi HW, Rhee S, Ryu JH, Park ZY, Jun CD, Song WK., Free PMC Article | 01/25/2014 |
| EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration. | EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease.
Ferrer-Acosta Y, Rodríguez-Cruz EN, Orange F, De Jesús-Cortés H, Madera B, Vaquer-Alicea J, Ballester J, Guinel MJ, Bloom GS, Vega IE., Free PMC Article | 08/10/2013 |
| the human Shu complex (hSWS1.SWSAP1) has an evolutionarily conserved function in homologous recombination | hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
Liu T, Wan L, Wu Y, Chen J, Huang J., Free PMC Article | 01/28/2012 |
| This protein has been found differentially expressed in thalami from patients with schizophrenia. | Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW. | 07/13/2010 |
| These results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway. | Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway.
Thylur RP, Kim YD, Kwon MS, Oh HM, Kwon HK, Kim SH, Im SH, Chun JS, Park ZY, Jun CD. | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| Its predominant presence in CD8 lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes. | Identification of swiprosin 1 in human lymphocytes.
Vuadens F, Rufer N, Kress A, Corthésy P, Schneider P, Tissot JD. | 01/21/2010 |