| BRCC36 regulates beta-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease. | BRCC36 regulates β-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease.
Li Y, Chen X, Xiong Y, Xu X, Xie C, Min M, Liang D, Chen C, Mao H., Free PMC Article | 10/11/2024 |
| BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension. | BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension.
Shen H, Gao Y, Ge D, Tan M, Yin Q, Wei TW, He F, Lee TY, Li Z, Chen Y, Yang Q, Liu Z, Li X, Chen Z, Yang Y, Zhang Z, Thistlethwaite PA, Wang J, Malhotra A, Yuan JX, Shyy JY, Gong K., | 08/1/2024 |
| Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression. | Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression.
Feng X, He S, Chen Y, Zhang L. | 05/7/2024 |
| The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells. | The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.
Huang Q, Zheng S, Gu H, Yang Z, Lu Y, Yu X, Guo G., Free PMC Article | 05/2/2024 |
| BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome. | BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.
Huang X, Tan J, Ji Y, Luo J, Zhao Y, Zhao J., Free PMC Article | 04/2/2024 |
| Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity. | Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity.
Sberna S, Lopez-Hernandez A, Biancotto C, Motta L, Andronache A, Verhoef LGGC, Caganova M, Campaner S., Free PMC Article | 11/16/2023 |
| Identification and Verification of the Ability of Cdk5 to Phosphorylate Deubiquitinating Enzyme BRCC3 In Vitro. | Identification and Verification of the Ability of Cdk5 to Phosphorylate Deubiquitinating Enzyme BRCC3 In Vitro.
Zhang CH, Qin K, Tian SL, Han Y, Xu SY, Shao XY. | 05/28/2022 |
| ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. | ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2.
Zhang W, Tao SS, Wang T, Zhang J, Liu X, Li YT, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Ren GM, Yang XM, Yin RH. | 07/17/2021 |
| BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling. | BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling.
Rabl J., Free PMC Article | 06/26/2021 |
| BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability. | BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.
Cheng Q, Feng Q, Xu Y, Zuo Y, Liu J, Yuan Y, Miao Y, Liu Y, Lei L, Guo T, Zhang L, Wu D, Zheng H. | 04/17/2021 |
| Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination. | Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.
Rao Z, Chen X, Wu J, Xiao M, Zhang J, Wang B, Fang L, Zhang H, Wang X, Yang S, Chen Y., Free PMC Article | 10/31/2020 |
| Cell lines and primary mouse cells with inactivation of BRCC3 had a higher sensitivity to doxorubicin. | Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1).
Meyer T, Jahn N, Lindner S, Röhner L, Dolnik A, Weber D, Scheffold A, Köpff S, Paschka P, Gaidzik VI, Heckl D, Wiese S, Ebert BL, Döhner H, Bullinger L, Döhner K, Krönke J., Free PMC Article | 08/12/2020 |
| BRCC3 expressed in oligodendrocyte precursor cells in vitro is required for the oligodendrocyte lineage progression toward the mature stage. Lack of BRCC3 function could deteriorate demyelination at the lesion site. An increase in Lys63-linked ubiquitination levels induced by the deregulation of BRCC3 expression promotes the endosomal/lysosomal processing of myelin proteins. | BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination.
Wang CY, Deneen B, Tzeng SF. | 02/22/2020 |
| Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site. In the BRISC structure, ABRO1 binds SHMT2alpha, a metabolic enzyme enabling cancer growth in hypoxic environments, which we find prevents BRCC36 from binding and cleaving ubiquitin chains | Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH., Free PMC Article | 01/18/2020 |
| a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling. | The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.
Donaghy R, Han X, Rozenova K, Lv K, Jiang Q, Doepner M, Greenberg RA, Tong W., Free PMC Article | 12/28/2019 |
| Luciferase reporter assay and in vitro rescue experiment confirmed that ANRIL promoted NLRP3 inflammasome activation by up-regulating BRCC3 expression via sponging miR-122-5p. | LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis.
Hu J, Wu H, Wang D, Yang Z, Dong J. | 03/2/2019 |
| Knockdown of BRCC3 in HeLa and SiHa cervical cancer cells revealed that BRCC3 interference inhibited the viability, in addition to the invasion and migration abilities, of cervical cancer cells via regulation of Snai family members and MMPs, which subsequently inhibit the progress of EMT. | Knockdown of BRCC3 exerts an anti‑tumor effect on cervical cancer in vitro.
Zhang F, Zhou Q., Free PMC Article | 02/2/2019 |
| this study shows that mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye | Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.
Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ., Free PMC Article | 02/24/2018 |
| In late S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex. | Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution.
Tripathi E, Smith S., Free PMC Article | 07/15/2017 |
| findings uncover a pivotal role of BRCC36 DUB in limiting DSB processing and repair and illustrate how cells may physically couple ubiquitin recognition and metabolizing activities for fine tuning of DNA repair processes. | The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair.
Ng HM, Wei L, Lan L, Huen MS., Free PMC Article | 05/13/2017 |
| BRCC3 may play a role in B7-H3-induced 5-Fu resistance. | B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu.
Sun ZZ, Zhang T, Ning K, Zhu R, Liu F, Tang SC, Jiang B, Hua D. | 03/11/2017 |
| BRCC3 inversely correlated with NPC overall and relapse-free survival. Its expression was higher in radioresistant NPC cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest. | BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro.
Tu Z, Xu B, Qu C, Tao Y, Chen C, Hua W, Feng G, Chang H, Liu Z, Li G, Jiang C, Yi W, Zeng M, Xia Y., Free PMC Article | 04/2/2016 |
| BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. | BRCC3 mutations in myeloid neoplasms.
Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Okuno Y, Nagae G, Hosono N, Schnittger S, Sanada M, Przychodzen B, Kon A, Polprasert C, Shen W, Clemente MJ, Phillips JG, Alpermann T, Yoshida K, Nadarajah N, Sekeres MA, Oakley K, Nguyen N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Miyano S, Haferlach C, Kern W, Haferlach T, Du Y, Ogawa S, Makishima H., Free PMC Article | 02/27/2016 |
| KIAA0157 allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity. | Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.
Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F., Free PMC Article | 12/26/2015 |
| upregulation of BRCC3 expression is associated with glioma. | Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide.
Chai KM, Wang CY, Liaw HJ, Fang KM, Yang CS, Tzeng SF., Free PMC Article | 09/5/2015 |