| Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess. | Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess.
Ruiz-Díaz MS, Mena-Yi D, Gómez-Camargo D, Mora-García G., Free PMC Article | 11/26/2022 |
| IRX3 plays an important role in the pathogenesis of metabolic-associated fatty liver disease by regulating hepatic lipid metabolism. | IRX3 plays an important role in the pathogenesis of metabolic-associated fatty liver disease by regulating hepatic lipid metabolism.
Ma Y, Chen G, Yi J, Li Q, Tan Z, Fan W, Luo X, He Z, Si Z, Li J., Free PMC Article | 09/3/2022 |
| The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia. | The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.
Nagel S, Pommerenke C, Meyer C, MacLeod RAF., Free PMC Article | 04/16/2022 |
| IRX3 Overexpression Enhances Ucp1 Expression In Vivo. | IRX3 Overexpression Enhances Ucp1 Expression In Vivo.
Zhang Z, Wu Q, He Y, Lu P, Li D, Yang M, Gu W, Liu R, Hong J, Wang J., Free PMC Article | 12/25/2021 |
| Clinical utility of irx3 in keratoconus. | Clinical utility of irx3 in keratoconus.
Markoulli M, Fedtke C, Coroneo M, Kalloniatis M, Whatham A, Yapp M, Zangerl B. | 10/2/2021 |
| Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults. | Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults.
Kong SH, Yoon JW, Kim JH, Park J, Choi J, Lee JH, Hong AR, Cho NH, Shin CS., Free PMC Article | 09/18/2021 |
| Hypothalamic IRX3: A New Player in the Development of Obesity. | Hypothalamic IRX3: A New Player in the Development of Obesity.
de Araújo TM, Velloso LA. | 08/7/2021 |
| Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. | Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA., Free PMC Article | 06/19/2021 |
| Primary preadipocytes from carriers of the obesity risk allele rs1421085, in which expression of IRX3 and IRX5 is increased, displayed excessive accumulation of triglycerides, reduced mitochondrial oxidative capacity, reduced white adipocyte browning, and reduced thermogenesis relative to primary preadipocytes from nonrisk allele carriers. | FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M, Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M., Free PMC Articles: PMC4959911, PMC4959911 | 06/14/2021 |
| Genome editing in primary preadipocytes to create the obesity risk allele of rs1421085 caused increased expression of IRX3 and IRX5 during early adipocyte differentiation by disrupting a binding site for the ARID5B repressor. | FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M, Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M., Free PMC Articles: PMC4959911, PMC4959911 | 06/14/2021 |
| Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects. | Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects.
Bañales-Luna M, Figueroa-Vega N, Marín-Aragón CI, Perez-Luque E, Ibarra-Reynoso L, Gallardo-Blanco HL, López-Aguilar I, Malacara JM., Free PMC Article | 12/12/2020 |
| Lifestyle modification may exert its effects on obesity through changes in the expression level of the FTO and IRX3 genes. However, FTO genotype plays a role in the extent of the effect of lifestyle changes on gene expression. | Changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing an intensive lifestyle intervention and the role of FTO genotype in this interaction.
Doaei S, Kalantari N, Izadi P, Salonurmi T, Mosavi Jarrahi A, Rafieifar S, Azizi Tabesh G, Rahimzadeh G, Gholamalizadeh M, Goodarzi MO., Free PMC Article | 07/18/2020 |
| Irx3 is required for preadipocyte identity and differentiation capacity. | The homeobox factor Irx3 maintains adipogenic identity.
Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. | 05/2/2020 |
| Promotion of IRX3 signalling or inhibition of IRX5 signalling could be a route towards differentiation therapy for Wilms tumour, in which WNT5A is a candidate molecule for enforced tubular maturation. | The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.
Holmquist Mengelbier L, Lindell-Munther S, Yasui H, Jansson C, Esfandyari J, Karlsson J, Lau K, Hui CC, Bexell D, Hopyan S, Gisselsson D., Free PMC Article | 12/21/2019 |
| Data show that hypothalamic Irx3 is down-regulated by prolonged fasting and by a high-fat diet. The hypothalamic inhibition of Irx3 results in increased body mass gain due to increased caloric intake and reduced energy expenditure accompanied by reduced BAT thermogenesis. Thus, Irx3 is abnormally regulated in diet-induced obesity, and further reducing its hypothalamic levels results in increased body mass. | The partial inhibition of hypothalamic IRX3 exacerbates obesity.
de Araujo TM, Razolli DS, Correa-da-Silva F, de Lima-Junior JC, Gaspar RS, Sidarta-Oliveira D, Victorio SC, Donato J Jr, Kim YB, Velloso LA., Free PMC Article | 06/15/2019 |
| IRX3 genetic variants associate with birth weight, body mass index and AST/ALT-related transaminase metabolism, supporting the role of IRX3 as an obesity-associated susceptibility gene. | IRX3 is a genetic modifier for birth weight, adolescent obesity and transaminase metabolism.
Liu C, Chu C, Zhang J, Wu D, Xu D, Li P, Chen Y, Liu B, Pei L, Zhang L, Liu S, Qi T, Lou XY, Li L. | 11/10/2018 |
| Results show that IRX3 deficiency repressed the browning program of white adipocytes partially by regulating UCP1 transcriptional activity. Rare variants of IRX3 were associated with human obesity. | IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk.
Zou Y, Lu P, Shi J, Liu W, Yang M, Zhao S, Chen N, Chen M, Sun Y, Gao A, Chen Q, Zhang Z, Ma Q, Ning T, Ying X, Jin J, Deng X, Shen B, Zhang Y, Yuan B, Kauderer S, Liu S, Hong J, Liu R, Ning G, Wang W, Gu W, Wang J., Free PMC Article | 06/23/2018 |
| Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy. | FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?
Landgraf K, Scholz M, Kovacs P, Kiess W, Körner A., Free PMC Article | 07/29/2017 |
| the association between FTO and obesity appears to be due to its influence on expression of IRX3 [Figure 1]. Genetic studies indicated FTO as an important gene for obesity risk in various populations but the recent developments suggest that obesity-associated FTO SNPs have long-range interactions with IRX3. | Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?
Mittal B, Srivastava A, Srivastava N., Free PMC Article | 05/20/2017 |
| Downregulation of miR-377 may contribute to the upregulation of IRX3 in HCC. | Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma.
Wang P, Zhuang C, Huang D, Xu K. | 03/11/2017 |
| This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians. | Association of FTO and IRX3 genetic variants to obesity risk in north India.
Srivastava A, Mittal B, Prakash J, Srivastava P, Srivastava N, Srivastava N. | 01/28/2017 |
| Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis. | The proangiogenic effect of iroquois homeobox transcription factor Irx3 in human microvascular endothelial cells.
Scarlett K, Pattabiraman V, Barnett P, Liu D, Anderson LM., Free PMC Article | 05/23/2015 |
| data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition | Obesity-associated variants within FTO form long-range functional connections with IRX3.
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA., Free PMC Article | 04/12/2014 |
| IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes. | Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
Ragvin A, Moro E, Fredman D, Navratilova P, Drivenes Ø, Engström PG, Alonso ME, de la Calle Mustienes E, Gómez Skarmeta JL, Tavares MJ, Casares F, Manzanares M, van Heyningen V, Molven A, Njølstad PR, Argenton F, Lenhard B, Becker TS., Free PMC Article | 03/1/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |