| High expression of DEC2 distinguishes chondroblastic osteosarcoma and promotes tumour growth by activating the VEGFC/VEGFR2 signalling pathway. | High expression of DEC2 distinguishes chondroblastic osteosarcoma and promotes tumour growth by activating the VEGFC/VEGFR2 signalling pathway.
Tuerxun M, Zheng X, Xu J, Yang Q, Yuan T, Zhang C, Zhou S., Free PMC Article | 10/30/2024 |
| BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues. | BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues.
Podleśny-Drabiniok A, Novikova G, Liu Y, Dunst J, Temizer R, Giannarelli C, Marro S, Kreslavsky T, Marcora E, Goate AM., Free PMC Article | 08/1/2024 |
| Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development. | Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development.
Furukawa T, Mimami K, Nagata T, Yamamoto M, Sato M, Tanimoto A., Free PMC Article | 08/3/2023 |
| Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma. | Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma.
Yang X, Wu JS, Li M, Zhang WL, Gao XL, Wang HF, Yu XH, Pang X, Zhang M, Liang XH, Tang YL., Free PMC Article | 12/25/2021 |
| BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma. | BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.
Nagata T, Minami K, Yamamoto M, Hiraki T, Idogawa M, Fujimoto K, Kageyama S, Tabata K, Kawahara K, Ueda K, Ikeda R, Kato Y, Komatsu M, Tanimoto A, Furukawa T, Sato M., Free PMC Article | 12/18/2021 |
| TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. | TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.
Carey KL, Paulus GLC, Wang L, Balce DR, Luo JW, Bergman P, Ferder IC, Kong L, Renaud N, Singh S, Kost-Alimova M, Nyfeler B, Lassen KG, Virgin HW, Xavier RJ., Free PMC Article | 11/13/2021 |
| The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation. | The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.
Wang X, Sato F, Tanimoto K, Rajeshwaran N, Thangavelu L, Makishima M, Bhawal UK., Free PMC Article | 10/30/2021 |
| DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma. | DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma.
Fang W, Li Q, Wang M, Zheng M, Xu H., Free PMC Article | 08/14/2021 |
| BHLHE41 suppresses MCF-7 cell invasion via MAPK/JNK pathway. | BHLHE41 suppresses MCF-7 cell invasion via MAPK/JNK pathway.
Zhang D, Zheng Q, Wang C, Zhao N, Liu Y, Wang E., Free PMC Article | 05/8/2021 |
| ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer. | ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.
Hu H, Chen Z, Ji L, Wang Y, Yang M, Lai R, Zhong Y, Zhang X, Wang L. | 02/20/2021 |
| MicroRNA-301a inhibits the progression of osteosarcoma by regulating DEC2. | MicroRNA-301a inhibits the progression of osteosarcoma by regulating DEC2.
Wu H, Yu Z, Chen Q, Li D, Chen W. | 02/13/2021 |
| The expression of BHLHE41 in clear cell renal cell carcinoma (ccRCC) was significantly increased in microarray datasets, RNA sequencing data, and in fresh ccRCC tissue samples, compared with than their adjacent nontumorous controls. BHLHE41 knockdown reduced cell proliferation and migration of A498 and CAKI1 cells. These observations demonstrated that BHLHE41 could be a biomarker and an oncogene for ccRCC. | Overexpression of BHLHE41, correlated with DNA hypomethylation in 3'UTR region, promotes the growth of human clear cell renal cell carcinoma.
Shen Z, Zhu L, Zhang C, Cui X, Lu J., Free PMC Article | 07/6/2019 |
| Suppression of SHARP1 induces robust apoptosis of human MLL-AF6 Acute Myeloid Leukemia cells. | The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.
Numata A, Kwok HS, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R, Tenen DG., Free PMC Article | 02/9/2019 |
| These results provide evidence that DEC1 and DEC2 have opposite effects on TGFbetainduced epithelialmesenchymal transition in human prostate cancer PC3 cells. | Correlation between DEC1/DEC2 and epithelial‑mesenchymal transition in human prostate cancer PC‑3 cells.
Liu Q, Wu Y, Seino H, Haga T, Yoshizawa T, Morohashi S, Kijima H., Free PMC Article | 01/12/2019 |
| We validated DEC2 gene as a direct target of miR-873 which could reverse the repressive effects of miR-873 on esophageal cancer cell. | MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2.
Liang Y, Zhang P, Li S, Li H, Song S, Lu B. | 11/17/2018 |
| Knockdown of DEC2 resulted in a significant (26.7%) reduction of VEGF expression in MIO-M1 cells under hypoxia-mimicking conditions induced by DFO (P < .05). Levels of HIF1alpha protein were also reduced significantly, by 60.2%, in MIO-M1 cells treated with siRNA against the DEC2 gene (P < .05). Moreover, HIF1alpha levels showed a significant (2.5-fold) increase in MIO-M1 cells overexpressing DEC2 (P < .05). | Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells.
Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T. | 11/17/2018 |
| Mutation in DCE2 gene is associated with short sleep behavioral trait. | DEC2 modulates orexin expression and regulates sleep.
Hirano A, Hsu PK, Zhang L, Xing L, McMahon T, Yamazaki M, Ptáček LJ, Fu YH., Free PMC Article | 09/8/2018 |
| It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. | Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41.
Bigot P, Colli LM, Machiela MJ, Jessop L, Myers TA, Carrouget J, Wagner S, Roberson D, Eymerit C, Henrion D, Chanock SJ., Free PMC Article | 08/25/2018 |
| venous levels lower in preeclampsia than in normal pregnancy | Maternal venous SHARP1 levels in preeclampsia.
Ersoy AO, Oztas E, Ozler S, Tokmak A, Ersoy E, Ergin M, Danisman N. | 06/16/2018 |
| The renal cell cancers associated polymorphic HIF-binding site at chromosome 12p12.1 regulates BHLHE41 expression. | Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt JL, Smythies J, Choudhry H, Goppelt-Struebe M, Ratcliffe PJ, Mole DR, Schödel J., Free PMC Article | 08/26/2017 |
| Findings suggest that basic helix-loop-helix family, member e41 protein (DEC2) suppresses cell cycle progression of the mesenchymal cells. | DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells.
Sasamoto T, Fujimoto K, Kanawa M, Kimura J, Takeuchi J, Harada N, Goto N, Kawamoto T, Noshiro M, Suardita K, Tanne K, Kato Y. | 03/25/2017 |
| DEC1, at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells. | Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells.
Liu Q, Wu Y, Yoshizawa T, Yan X, Morohashi S, Seino H, Kato Y, Kijima H., Free PMC Article | 03/18/2017 |
| the present study indicated that SHARP1 acts as a tumor suppressor in thyroid cancer and that its downregulation may contribute to the proliferation, migration and invasion of thyroid cancer cells through mechanisms possibly involving HIF1alpha | Roles of SHARP1 in thyroid cancer.
Zhou ZH, Wang B, Cheng XB, Zhang XE, Tang J, Tang WJ, Gu L. | 02/18/2017 |
| Study found that DEC2 was a direct target of miR-138. | MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2.
Jiang B, Mu W, Wang J, Lu J, Jiang S, Li L, Xu H, Tian H., Free PMC Article | 12/17/2016 |
| DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta as well as other inflammatory genes. | Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis.
Olkkonen J, Kouri VP, Hynninen J, Konttinen YT, Mandelin J., Free PMC Article | 07/30/2016 |