| The JmjC-domain protein NO66/RIOX-1 affects the balance between proliferation and maturation in acute myeloid leukemia. | The JmjC-domain protein NO66/RIOX-1 affects the balance between proliferation and maturation in acute myeloid leukemia.
Yu W, Lutz C, Krämer A, Schmidt-Zachmann MS. | 09/25/2021 |
| NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling. | NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Deng H, Yu B, Yu Y, Tian G, Yang L. | 05/1/2021 |
| Mechanisms Regulating Muscle Protein Synthesis in CKD. | Mechanisms Regulating Muscle Protein Synthesis in CKD.
Zhang L, Chen Q, Chen Z, Wang Y, Gamboa JL, Ikizler TA, Garibotto G, Mitch WE., Free PMC Article | 03/13/2021 |
| The role of NO66 as a key oncogenic driver in Prostate cancer, causing osteolytic lesions through upstream epigenetic regulation of key genes for survival, invasion and metastasis, and pro-osteoclastic factors. | Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer.
Sinha KM, Bagheri-Yarmand R, Lahiri S, Lu Y, Zhang M, Amra S, Rizvi Y, Wan X, Navone N, Ozpolat B, Logothetis C, Gagel RF, Huard J. | 12/21/2019 |
| High NO66 expression is associated with Glioma. | The Histone Demethylase NO66 Induces Glioma Cell Proliferation.
Wang Q, Liu PY, Liu T, Lan Q. | 11/30/2019 |
| our findings clearly indicated that epigenetic regulation by NO66 plays an important role in cancer metastatic processes in CRC. | Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer.
Nishizawa Y, Nishida N, Konno M, Kawamoto K, Asai A, Koseki J, Takahashi H, Haraguchi N, Nishimura J, Hata T, Matsuda C, Mizushima T, Satoh T, Doki Y, Mori M, Ishii H. | 02/24/2018 |
| Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival. | Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication.
Pires-Luís AS, Vieira-Coimbra M, Vieira FQ, Costa-Pinheiro P, Silva-Santos R, Dias PC, Antunes L, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C., Free PMC Article | 10/22/2016 |
| confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8 | Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.
Wang C, Zhang Q, Hang T, Tao Y, Ma X, Wu M, Zhang X, Zang J., Free PMC Article | 06/11/2016 |
| hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx-dependent gene activation. | Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression.
Tao Y, Wu M, Zhou X, Yin W, Hu B, de Crombrugghe B, Sinha KM, Zang J., Free PMC Article | 08/31/2013 |
| NO66 crystallized in space group P3(1) or P3(2), with unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha = beta = 90, gamma = 120 degrees , and the crystal is likely to contain four molecules in the asymmetric unit | Purification, crystallization and preliminary crystallographic analysis of histone lysine demethylase NO66 from Homo sapiens.
Zhou X, Tao Y, Wu M, Zhang D, Zang J., Free PMC Article | 09/29/2012 |
| interactions between NO66 and Osx regulate Osx-target genes in osteoblasts by modulating histone methylation states | Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.
Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B., Free PMC Article | 02/8/2010 |
| NO66 has functions in ribosome biogenesis and in the replication or remodeling of certain heterochromatic regions | NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin.
Eilbracht J, Reichenzeller M, Hergt M, Schnölzer M, Heid H, Stöhr M, Franke WW, Schmidt-Zachmann MS., Free PMC Article | 01/21/2010 |