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    LIN28A lin-28 homolog A [ Homo sapiens (human) ]

    Gene ID: 79727, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis.

    Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis.
    Zhang XY, Zhu BC, He M, Dong SS., Free PMC Article

    07/30/2024
    Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.

    Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
    Zhou S, Guo L, Cui X, Zhang X, Yang Y, Zhang M, Zhang P.

    06/21/2024
    GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-kappaB/NLRP3 inflammasome pathway.

    GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway.
    Guo L, Sun H, Pu J.

    05/31/2024
    Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.

    Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.
    Oyejobi GK, Yan X, Sliz P, Wang L., Free PMC Article

    04/17/2024
    Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.

    Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.
    Zhou F, Wu H, Yin Z, Zhou W, Chen W.

    03/14/2024
    Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.

    Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28.
    Yang C, Zhang Y, Yan M, Wang J, Wang J, Wang M, Xuan Y, Cheng H, Ma J, Chai C, Li M, Yu Z., Free PMC Article

    01/27/2024
    Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.

    Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.
    Jung S, Ko SH, Ahn N, Lee J, Park CH, Hwang J., Free PMC Article

    01/9/2024
    Lin28 promoting the protective effect of PMSCs on hepatic ischaemia-reperfusion injury by regulating glucose metabolism.

    Lin28 promoting the protective effect of PMSCs on hepatic ischaemia-reperfusion injury by regulating glucose metabolism.
    Zhou X, Li J, Wang J, Yang H, Xie X, Chen Z, Zhang B., Free PMC Article

    05/17/2023
    Analysis of LIN28A variants in patients with Parkinson's disease.

    Analysis of LIN28A variants in patients with Parkinson's disease.
    Peng H, Li Y, Yoshino H, Shimizu M, Nishioka K, Funayama M, Hattori N.

    04/28/2023
    LIN28 expression and function in medulloblastoma.

    LIN28 expression and function in medulloblastoma.
    Maklad A, Sedeeq M, Wilson R, Heath JA, Gueven N, Azimi I.

    03/28/2023
    Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression.

    Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression.
    Chen J, Liu W.

    01/28/2023
    Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1.

    Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1.
    Zhuo ZL, Xian HP, Sun YJ, Long Y, Liu C, Liang B, Zhao XT., Free PMC Article

    10/1/2022
    The association between LIN28A gene rare variants and Parkinson's disease in Chinese population.

    The association between LIN28A gene rare variants and Parkinson's disease in Chinese population.
    Huang X, Zhao Y, Pan H, Wang Y, Liu Z, Xu Q, Sun Q, Tan J, Yan X, Li J, Tang B, Guo J.

    07/30/2022
    LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy.

    LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy.
    Song P, Chen Y, Liu Z, Liu H, Xiao L, Sun L, Wei J, He L., Free PMC Article

    07/23/2022
    Association Between LIN28A Gene Polymorphisms and Glioma Susceptibility in Chinese Children.

    Association Between LIN28A Gene Polymorphisms and Glioma Susceptibility in Chinese Children.
    Guo H, Liao Y, Lin A, Lin H, Huang X, Ruan J, Yuan L, Zhuo Z., Free PMC Article

    04/23/2022
    Overexpression of Lin28a induces a primary ovarian insufficiency phenotype via facilitation of primordial follicle activation in mice.

    Overexpression of Lin28a induces a primary ovarian insufficiency phenotype via facilitation of primordial follicle activation in mice.
    Chen J, Liu W, Lee KF, Liu K, Wong BPC, Shu-Biu Yeung W.

    04/2/2022
    LINC01451 drives epithelial-mesenchymal transition and progression in bladder cancer cells via LIN28/TGF-beta/Smad pathway.

    LINC01451 drives epithelial-mesenchymal transition and progression in bladder cancer cells via LIN28/TGF-β/Smad pathway.
    Shi H, Xie J, Wang K, Li W, Yin L, Wang G, Wu Z, Ni J, Mao W, Guo C, Peng B.

    01/22/2022
    Assessment of LIN28A variants in Parkinson's disease in large European cohorts.

    Assessment of LIN28A variants in Parkinson's disease in large European cohorts.
    Diez-Fairen M, Makarious MB, Bandres-Ciga S, Blauwendraat C, International Parkinson's Disease Genomics Consortium (IPDGC)., Free PMC Article

    01/15/2022
    Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression.

    Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression.
    Zhong Y, Cao L, Ma H, Wang Q, Wei P, Yang J, Mo Y, Cao L, Shuai C, Peng S., Free PMC Article

    11/13/2021
    Lin28a attenuates TGF-beta-induced renal fibrosis.

    Lin28a attenuates TGF-β-induced renal fibrosis.
    Jung GS, Hwang YJ, Choi JH, Lee KM., Free PMC Article

    08/21/2021
    Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain.

    Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain.
    Samsonova A, El Hage K, Desforges B, Joshi V, Clément MJ, Lambert G, Henrie H, Babault N, Craveur P, Maroun RC, Steiner E, Bouhss A, Maucuer A, Lyabin DN, Ovchinnikov LP, Hamon L, Pastré D., Free PMC Article

    08/14/2021
    SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.

    SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.
    Dou J, Zhang H, Chen R, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A, Yu J., Free PMC Article

    07/10/2021
    Sjogren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.

    Sjögren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.
    Kim SH, Park BO, Kim K, Park BC, Park SG, Kim JH, Kim S.

    07/3/2021
    Identification of Let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer.

    Identification of Let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer.
    Shee K, Seigne JD, Karagas MR, Marsit CJ, Hinds JW, Schned AR, Pettus JR, Armstrong DA, Miller TW, Andrew AS.

    06/12/2021
    MicroRNA-126 suppresses the invasion of trophoblast-model JEG-3 cells by targeting LIN28A.

    MicroRNA-126 suppresses the invasion of trophoblast-model JEG-3 cells by targeting LIN28A.
    Pan X, Noguchi S, Ando M, Nishimura T, Tomi M.

    05/15/2021
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