| Expanding the phenotypic spectrum and clinical severity associated with WLS gene. | Expanding the phenotypic spectrum and clinical severity associated with WLS gene.
Abdel-Salam GMH, Afifi HH, Abdel-Hamid MS, Ahmed NEB, Taher MB, El-Kamah G, Thiele H, Nürnberg PN, Bolz HJ. | 09/6/2023 |
| Compound heterozygous variants in WLS gene causes Zaki syndrome. | Compound heterozygous variants in WLS gene causes Zaki syndrome.
Yu C, Wang C, Zhou W, Zhang A, Jia Z, Zheng B, Ding G. | 07/7/2023 |
| Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis. | Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis.
Kantaputra P, Tripuwabhrut K, Jatooratthawichot P, Adisornkanj P, Hatsadaloi A, Porntrakoolsaree N, Kaewgaya M, Olsen B, Tongsima S, Ngamphiw C, Ketudat Cairns JR. | 06/1/2023 |
| The role of Evi/Wntless in exporting Wnt proteins. | The role of Evi/Wntless in exporting Wnt proteins.
Wolf L, Boutros M., Free PMC Article | 02/23/2023 |
| GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. | GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
Xie YK, Luo H, Zhang SX, Chen XY, Guo R, Qiu XY, Liu S, Wu H, Chen WB, Zhen XH, Ma Q, Tian JL, Li S, Chen X, Han Q, Duan S, Shen C, Yang F, Xu ZZ. | 04/23/2022 |
| Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses. | Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses.
Mohamed R, Kennedy C, Willmore WG. | 04/9/2022 |
| Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. | Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
Nygaard R, Yu J, Kim J, Ross DR, Parisi G, Clarke OB, Virshup DM, Mancia F., Free PMC Article | 08/28/2021 |
| Cryo-EM structure of human Wntless in complex with Wnt3a. | Cryo-EM structure of human Wntless in complex with Wnt3a.
Zhong Q, Zhao Y, Ye F, Xiao Z, Huang G, Xu M, Zhang Y, Zhan X, Sun K, Wang Z, Cheng S, Feng S, Zhao X, Zhang J, Lu P, Xu W, Zhou Q, Ma D., Free PMC Article | 08/7/2021 |
| SNHG17 upregulates WLS expression to accelerate lung adenocarcinoma progression by sponging miR-485-5p. | SNHG17 upregulates WLS expression to accelerate lung adenocarcinoma progression by sponging miR-485-5p.
Li W, Zheng Y, Mao B, Wang F, Zhong Y, Cheng D. | 03/28/2021 |
| MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells. | MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells.
Jung JE, Lee JY, Kim IR, Park SM, Kang JW, Kim YH, Park HR, Lee JH., Free PMC Article | 02/27/2021 |
| WLS is an important locus for osteoporosis and its related quantitative phenotypes in a large sample derived from the Chinese Han population. In addition to the significant single SNPs that we identified, a possible regulatory role for the 20 kb genomic region around the most significant SNP, rs2566752, was defined by combining our results with ENCODE histone mark data. | Genetic association study identified a 20 kb regulatory element in WLS associated with osteoporosis and bone mineral density in Han Chinese.
Zhang D, Ge Z, Ma X, Zhi L, Zhang Y, Wu X, Yao S, Ma W., Free PMC Article | 08/10/2019 |
| GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of gastric cancer patients. | Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis.
Seo J, Kee HJ, Choi HJ, Lee JE, Park SY, Lee SH, Jeong MH, Guk G, Lee S, Choi KC, Choi YY, Kim H, Noh SH, Yoon HG, Cheong JH., Free PMC Article | 10/6/2018 |
| Wls is differentially expressed in Intrahepatic Cholangiocarcinoma tissues and positively related to tumor stage and lymphatic invasion. | Wntless Is Highly Expressed in Advanced-Stage Intrahepatic Cholangiocarcinoma.
Shi Y, Bai J, Guo S, Wang J. | 09/8/2018 |
| This study provides a brand new evidence that GOLPH3 promotes glioma cell proliferation by facilitating Wls recycling and Wnt/beta-catenin signaling. | Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression.
Lu D, Zhang H, Fu J, Qi Y, Wang X, Wu S, Zhou X, Yu R. | 08/18/2018 |
| These data showed that Wls was differentially expressed in HCC. Statistical analysis results suggest that Wls expression might increase as HCC progresses. | Wls Expression Correlates with Tumor Differentiation and TNM Stage in Hepatocellular Carcinoma.
Zhou C, Sun Y, Guo S, Chen X, Bao G, Wang J. | 05/26/2018 |
| Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands | A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export.
Sun J, Yu S, Zhang X, Capac C, Aligbe O, Daudelin T, Bonder EM, Gao N., Free PMC Article | 03/31/2018 |
| we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs. | Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.
Hsu YH, Li G, Liu CT, Brody JA, Karasik D, Chou WC, Demissie S, Nandakumar K, Zhou Y, Cheng CH, Gill R, Gibbs RA, Muzny D, Santibanez J, Estrada K, Rivadeneira F, Harris T, Gudnason V, Uitterlinden A, Psaty BM, Robbins JA, Adrienne Cupples L, Kiel DP., Free PMC Article | 07/29/2017 |
| Our data suggest that Wls protein is related to tumor metastasis and advanced TNM stage, and may be used as a new marker for prognosis of gastric carcinoma. | High expression of Wls is associated with lymph node metastasis and advanced TNM stage in gastric carcinomas.
Zhang W, Tao H, Chen X, Sugimura H, Wang J, Zhou P. | 03/18/2017 |
| These results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma. | Expression of Wntless in colorectal carcinomas is associated with invasion, metastasis, and poor survival.
Xu H, Jiang W, Zhu F, Zhu C, Wei J, Wang J. | 02/4/2017 |
| Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress. | Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.
Zhang P, Zhou L, Pei C, Lin X, Yuan Z., Free PMC Article | 12/24/2016 |
| Genetic variation at the WLS and CCDC170/ESR1 loci were found to be significantly associated with bone mineral density | Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.
Mullin BH, Walsh JP, Zheng HF, Brown SJ, Surdulescu GL, Curtis C, Breen G, Dudbridge F, Richards JB, Spector TD, Wilson SG., Free PMC Article | 10/1/2016 |
| This study has revealed a strong association between the expression of WLS and HER2 that has important biological and clinical implications. | Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.
Stewart J, James J, McCluggage GW, McQuaid S, Arthur K, Boyle D, Mullan P, McArt D, Yan B, Irwin G, Harkin DP, Zhengdeng L, Ong CW, Yu J, Virshup DM, Salto-Tellez M. | 11/21/2015 |
| This study identified CMTM8 as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene in osteosarcoma. | Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma.
Both J, Krijgsman O, Bras J, Schaap GR, Baas F, Ylstra B, Hulsebos TJ., Free PMC Article | 10/3/2015 |
| GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia. | Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling.
Chiou SS, Wang LT, Huang SB, Chai CY, Wang SN, Liao YM, Lin PC, Liu KY, Hsu SH. | 05/16/2015 |
| endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi. | WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.
Yu J, Chia J, Canning CA, Jones CM, Bard FA, Virshup DM. | 07/12/2014 |