| CST-polymerase alpha-primase solves a second telomere end-replication problem. | CST-polymerase α-primase solves a second telomere end-replication problem.
Takai H, Aria V, Borges P, Yeeles JTP, de Lange T., Free PMC Article | 04/3/2024 |
| CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection. | CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection.
Jaiswal RK, Lei KH, Chastain M, Wang Y, Shiva O, Li S, You Z, Chi P, Chai W., Free PMC Article | 12/6/2023 |
| Reconstitution of a telomeric replicon organized by CST. | Reconstitution of a telomeric replicon organized by CST.
Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR., Free PMC Article | 09/3/2022 |
| Structures of the human CST-Polalpha-primase complex bound to telomere templates. | Structures of the human CST-Polα-primase complex bound to telomere templates.
He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ., Free PMC Article | 09/3/2022 |
| Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology. | Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology.
Dos Santos GA, Viana NI, Pimenta R, de Camargo JA, Guimaraes VR, Romão P, Candido P, Ghazarian V, Reis ST, Leite KRM, Srougi M. | 05/7/2022 |
| Novel compound heterozygous STN1 variants are associated with Coats Plus syndrome. | Novel compound heterozygous STN1 variants are associated with Coats Plus syndrome.
Acharya T, Firth HV, Dugar S, Grammatikopoulos T, Seabra L, Walters A, Crow YJ, Parker APJ., Free PMC Article | 03/26/2022 |
| CST in maintaining genome stability: Beyond telomeres. | CST in maintaining genome stability: Beyond telomeres.
Lyu X, Sang PB, Chai W., Free PMC Article | 08/21/2021 |
| Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population. | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population.
Chang X, Gurung RL, Wang L, Jin A, Li Z, Wang R, Beckman KB, Adams-Haduch J, Meah WY, Sim KS, Lim WK, Davila S, Tan P, Teo JX, Yeo KK, M Y, Liu S, Lim SC, Liu J, van Dam RM, Friedlander Y, Koh WP, Yuan JM, Khor CC, Heng CK, Dorajoo R., Free PMC Article | 08/7/2021 |
| An Indian child with Coats plus syndrome due to mutations in STN1. | An Indian child with Coats plus syndrome due to mutations in STN1.
Passi GR, Shamim U, Rathore S, Joshi A, Mathur A, Parveen S, Sharma P, Crow YJ, Faruq M. | 06/12/2021 |
| Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA. | Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA.
Lyu X, Lei KH, Biak Sang P, Shiva O, Chastain M, Chi P, Chai W., Free PMC Article | 04/24/2021 |
| The study investigated whether six genetic variants previously associated with leukocyte telomere length are correlated with telomere length in peripheral blood mononuclear cells in a cohort of Africans living with and without HIV and undergoing evaluation for tuberculosis (TB). OBFC1 and the genetic sum score of the effect alleles across all six loci were found to be associated with shorter telomere length. | Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.
Wang S, Chang E, Byanyima P, Huang P, Sanyu I, Musisi E, Sessolo A, Davis JL, Worodria W, Huang L, Lin J, Inflammation, Aging, Microbes and Obstructive Lung Disease (I AM OLD) Study., Free PMC Article | 05/16/2020 |
| CST functions in two distinct aspects of genome-wide DNA replication, namely, origin licensing and replisome assembly. CST interacts with additional replisome components, MCM and AND-1. | Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association.
Wang Y, Brady KS, Caiello BP, Ackerson SM, Stewart JA., Free PMC Article | 02/29/2020 |
| The CST complex (CTC1-STN1-TEN1) maintains genome integrity through resolution of G4 structures both ahead of the replication fork and on the lagging strand template | Mammalian CST averts replication failure by preventing G-quadruplex accumulation.
Zhang M, Wang B, Li T, Liu R, Xiao Y, Geng X, Li G, Liu Q, Price CM, Liu Y, Wang F., Free PMC Article | 12/7/2019 |
| Association of OBFC1 gene single nucleotide polymorphisms with laryngeal carcinoma in Chinese Han male population. | Association of SNPs in the OBFC1 gene and laryngeal carcinoma in Chinese Han male population.
Han P, Dang Z, Shen Z, Dai H, Bai Y, Li B, Shao Y. | 11/30/2019 |
| Impaired interaction between CTC1(L1142H) :STN1 and DNA Pol-alpha results in increased telomerase recruitment to telomeres and further telomere elongation, revealing that C:S binding to DNA Pol-alpha is required to fully repress telomerase activity. | CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length.
Gu P, Jia S, Takasugi T, Smith E, Nandakumar J, Hendrickson E, Chang S., Free PMC Article | 10/12/2019 |
| The strongest association with prevalence of overall Cancer was observed for rs9420907 (OBFC1). | Telomere Length and Risk of Cardiovascular Disease and Cancer.
Said MA, Eppinga RN, Hagemeijer Y, Verweij N, van der Harst P. | 06/1/2019 |
| Studies indicate telomere-binding proteins CTC1-STN1-TEN1 (CST) dysfunction and mutation is associated with several genetic diseases and cancers [Review]. | Emerging roles of CST in maintaining genome stability and human disease.
Stewart JA, Wang Y, Ackerson SM, Schuck PL., Free PMC Article | 02/2/2019 |
| Human STN1, like yeast STN1, is regulated by overlapping open reading frames that strongly reduce STN1 expression. We show that levels of Stn1 in yeast and human cells are reduced by the presence of an upstream overlapping open reading frame. | Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function.
Torrance V, Lydall D., Free PMC Article | 01/19/2019 |
| CTC1-STN1 terminates TERT while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. | CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.
Feng X, Hsu SJ, Bhattacharjee A, Wang Y, Diao J, Price CM., Free PMC Article | 12/22/2018 |
| CTC1/STN1/TEN1 (CST) deficiency diminishes HU-induced RAD51 foci formation. | Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress.
Chastain M, Zhou Q, Shiva O, Fadri-Moskwik M, Whitmore L, Jia P, Dai X, Huang C, Ye P, Chai W., Free PMC Article | 11/18/2017 |
| STN1-POLA2 interaction provides a basis for primase-polymerase alpha stimulation by human STN1. A disease-causing mutation in human STN1 engenders a selective defect in POLA2-binding. | STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.
Ganduri S, Lue NF., Free PMC Article | 10/28/2017 |
| The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells. | The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.
Huang C, Jia P, Chastain M, Shiva O, Chai W., Free PMC Article | 10/7/2017 |
| TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance. | CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.
Feng X, Hsu SJ, Kasbek C, Chaiken M, Price CM., Free PMC Article | 09/16/2017 |
| Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. | Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Barel O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R., Free PMC Article | 07/29/2017 |
| The mammalian CST (CTC1-STN1-TEN1) complex is directly involved at several stages of telomere end formation and CST seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication. | CST for the grand finale of telomere replication.
Chen LY, Lingner J., Free PMC Article | 12/23/2016 |