| Implications of TRPM3 and TRPM8 for sensory neuron sensitisation. | Implications of TRPM3 and TRPM8 for sensory neuron sensitisation.
Behrendt M. | 10/25/2024 |
| The newest TRP channelopathy: Gain of function TRPM3 mutations cause epilepsy and intellectual disability. | The newest TRP channelopathy: Gain of function TRPM3 mutations cause epilepsy and intellectual disability.
Zhao S, Rohacs T., Free PMC Article | 08/26/2024 |
| Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants. | Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.
Marshall-Gradisnik S, Martini Sasso E, Eaton-Fitch N, Smith P, Baraniuk JN, Muraki K., Free PMC Article | 07/12/2024 |
| A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens. | A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.
Zhou Y, Bennett TM, Ruzycki PA, Guo Z, Cao YQ, Shahidullah M, Delamere NA, Shiels A., Free PMC Article | 02/16/2024 |
| Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders. | Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders.
Kashio M, Tominaga M. | 02/28/2023 |
| Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders. | Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders.
Burglen L, Van Hoeymissen E, Qebibo L, Barth M, Belnap N, Boschann F, Depienne C, De Clercq K, Douglas AGL, Fitzgerald MP, Foulds N, Garel C, Helbig I, Held K, Horn D, Janssen A, Kaindl AM, Narayanan V, Prager C, Rupin-Mas M, Afenjar A, Zhao S, Ramaekers VT, Ruggiero SM, Thomas S, Valence S, Van Maldergem L, Rohacs T, Rodriguez D, Dyment D, Voets T, Vriens J., Free PMC Article | 02/4/2023 |
| Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Zhao C, MacKinnon R. | 01/14/2023 |
| Computational and functional studies of the PI(4,5)P2 binding site of the TRPM3 ion channel reveal interactions with other regulators. | Computational and functional studies of the PI(4,5)P(2) binding site of the TRPM3 ion channel reveal interactions with other regulators.
Zhao S, Carnevale V, Gabrielle M, Gianti E, Rohacs T., Free PMC Article | 12/17/2022 |
| TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms. | TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms.
Behrendt M. | 07/16/2022 |
| Phenotypic spectrum of the recurrent TRPM3 p.(Val837Met) substitution in seven individuals with global developmental delay and hypotonia. | Phenotypic spectrum of the recurrent TRPM3 p.(Val837Met) substitution in seven individuals with global developmental delay and hypotonia.
Lines MA, Goldenberg P, Wong A, Srivastava S, Bayat A, Hove H, Karstensen HG, Anyane-Yeboa K, Liao J, Jiang N, May A, Guzman E, Morleo M, D'Arrigo S, Ciaccio C, Pantaleoni C, Castello R, TUDP Study Group, McKee S, Ong J, Zibdeh-Lough H, Tran-Mau-Them F, Gerasimenko A, Heron D, Keren B, Margot H, de Sainte Agathe JM, Burglen L, Voets T, Vriens J, Innes AM, Dyment DA. | 05/21/2022 |
| A novel candidate gene in autosomal dominant facial pruritus. | A novel candidate gene in autosomal dominant facial pruritus.
Thompson BA, Dear K, Donaldson E, Nixon R, Winship IM. | 03/5/2022 |
| The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients. | The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP(2) and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients.
Eaton-Fitch N, Cabanas H, du Preez S, Staines D, Marshall-Gradisnik S., Free PMC Article | 09/18/2021 |
| Functional expression and pharmacological modulation of TRPM3 in human sensory neurons. | Functional expression and pharmacological modulation of TRPM3 in human sensory neurons.
Vangeel L, Benoit M, Miron Y, Miller PE, De Clercq K, Chaltin P, Verfaillie C, Vriens J, Voets T., Free PMC Article | 07/17/2021 |
| Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms. | Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms.
Zhao S, Yudin Y, Rohacs T., Free PMC Article | 06/26/2021 |
| Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy. | Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy.
Van Hoeymissen E, Held K, Nogueira Freitas AC, Janssens A, Voets T, Vriens J., Free PMC Article | 03/20/2021 |
| TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves. | TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves.
Liu J, Zhao M, Chen Z, Xu Y, Guo L, Wang S, Li Y, Shi B, Zhang X, Jin XD. | 03/6/2021 |
| Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes. | Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes.
Lötsch J, Kringel D, Geisslinger G, Oertel BG, Resch E, Malkusch S., Free PMC Article | 02/13/2021 |
| The structural basis for an on-off switch controlling Gbetagamma-mediated inhibition of TRPM3 channels. | The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels.
Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J., Free PMC Article | 02/2/2021 |
| Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. | Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.
Cabanas H, Muraki K, Staines D, Marshall-Gradisnik S., Free PMC Article | 10/24/2020 |
| Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients. | Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients.
Balinas C, Cabanas H, Staines D, Marshall-Gradisnik S., Free PMC Article | 09/19/2020 |
| activation of Gs- and Gq-coupled G-protein-coupled receptors in recombinant cells and sensory neurons inhibits TRPM3 via Gbetagamma liberation | Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits.
Alkhatib O, da Costa R, Gentry C, Quallo T, Bevan S, Andersson DA., Free PMC Article | 06/27/2020 |
| Our findings suggest that TRPM3 is a locus for ID and epilepsy, and should be included in genetic panels targeting these indications. | De novo substitutions of TRPM3 cause intellectual disability and epilepsy.
Dyment DA, Terhal PA, Rustad CF, Tveten K, Griffith C, Jayakar P, Shinawi M, Ellingwood S, Smith R, van Gassen K, McWalter K, Innes AM, Lines MA., Free PMC Article | 06/20/2020 |
| In the three-stage genome-wide association study in South Korean population the signal in TRPM3 showed the most robust association with thyroid nodules, and those in MIBP/NKX2-1 also demonstrated a possible association. A rs4745021 variant at TRPM3 reached the genome-wide significance threshold in the meta-analysis. | Genome-Wide Association Study Reveals Distinct Genetic Susceptibility of Thyroid Nodules From Thyroid Cancer.
Hwangbo Y, Lee EK, Son HY, Im SW, Kwak SJ, Yoon JW, Kim MJ, Kim J, Choi HS, Ryu CH, Lee YJ, Kim JI, Cho NH, Park YJ. | 09/14/2019 |
| Study confirmed a significant reduction in amplitude of TRPM3 currents after pregnenolone sulfate stimulation in isolated NK cells from another cohort of CFS/ME patients compared with healthy controls. | Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients.
Cabanas H, Muraki K, Balinas C, Eaton-Fitch N, Staines D, Marshall-Gradisnik S., Free PMC Article | 08/17/2019 |
| Mutations of lysine residues in calmodulin binding site 2, strongly reduced calmodulin binding and TRPM3 activity indicating the importance of this domain for TRMP3-mediated calcium signaling. | Ca(2+)-dependent regulation and binding of calmodulin to multiple sites of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels.
Przibilla J, Dembla S, Rizun O, Lis A, Jung M, Oberwinkler J, Beck A, Philipp SE. | 05/11/2019 |