| ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes. | ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes.
Klæstad E, Sawicka JE, Engstrøm MJ, Ytterhus B, Valla M, Bofin AM. | 08/14/2021 |
| ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15. | ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15.
Wang S, Wang C, Hu Y, Li X, Jin S, Liu O, Gou R, Zhuang Y, Guo Q, Nie X, Zhu L, Liu J, Lin B., Free PMC Article | 08/7/2021 |
| Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression. | Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression.
Wang H, Xu H, Ma F, Zhan M, Yang X, Hua S, Li W, Li Y, Lu L., Free PMC Article | 04/13/2021 |
| Transcription factor ZNF703 activates linc-UBC1 to stimulate the progression of glioma. | Transcription factor ZNF703 activates linc-UBC1 to stimulate the progression of glioma.
Wang J, Zhu LS, Luo Y, Wang CH, Wei YY, Zhou LM. | 03/20/2021 |
| ZNF703 is Overexpressed in Papillary Thyroid Carcinoma Tissues and Mediates K1 Cell Proliferation. | ZNF703 is Overexpressed in Papillary Thyroid Carcinoma Tissues and Mediates K1 Cell Proliferation.
Yang X, Liu G, Zang L, Li D, Yu F, Xiang X, Li W. | 01/16/2021 |
| ZNF703 is an important player in head and neck cancer. | ZNF703 is an important player in head and neck cancer.
Orhan C, Bakır B, Dalay N, Buyru N. | 10/24/2020 |
| ZNF703 may have potential as a therapeutic target. | Apoptotic Effects of Linum album Extracts on AGS Human Gastric Adenocarcinoma Cells and ZNF703 Oncogene Expression.
Akbari Asl E, Fallah Mehrabadi J, Afshar D, Noorbazargan H, Tahmasebi H, Rahimi A., Free PMC Article | 02/9/2019 |
| ZNF703 can potently facilitate tumor growth and metastasis in many respects throughout the progression of CCA, which may act as an oncogene in CCA and can be considered as a novel potential therapeutic target. | Overexpression of ZNF703 facilitates tumorigenesis and predicts unfavorable prognosis in patients with cholangiocarcinoma.
Li K, Wang J, Han J, Lan Y, Xie C, Pan S, Liu L., Free PMC Article | 02/10/2018 |
| Results show that ZNF703 is up-regulated in 63.4% of non-small cell lung cancer (NSCLC) tumor samples and it may contribute to tumor development by activating the Akt/mTOR pathway in NSCLC. | ZNF703 Overexpression may act as an oncogene in non-small cell lung cancer.
Baykara O, Dalay N, Kaynak K, Buyru N., Free PMC Article | 11/18/2017 |
| In vitro function assays demonstrated that SPRY4-IT1 cause promotion of cell viability in ESCC cells. Authors further verified that SPRY4-IT1 could also activate the expression of ZNF703 in ESCC cells, which might contribute to the role of SPRY4-IT1 in ESCC cells. | Upregulated long noncoding RNA SPRY4-IT1 contributes to increased cell viability by activating zinc finger 703 expression in esophageal squamous cell carcinoma.
Xue-Liang J, Ming-Dong W, Ya-Bi Z, Wang-Yue W. | 04/8/2017 |
| Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm. | Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.
Yang H, Jiang WQ, Cao Y, Sun YA, Wei J, An X, Zhang YC, Song M, Wang SS, Yuan ZY, Peng RJ, Chen TH, Li LR, Shi YX., Free PMC Article | 03/5/2016 |
| ZNF703 was a target of SPRY4-IT1. | The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.
Shi Y, Li J, Liu Y, Ding J, Fan Y, Tian Y, Wang L, Lian Y, Wang K, Shu Y., Free PMC Article | 01/16/2016 |
| Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene in CRC. | ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer.
Ma F, Bi L, Yang G, Zhang M, Liu C, Zhao Y, Wang Y, Wang J, Bai Y, Zhang Y. | 11/7/2015 |
| The results showed that ZNF703 acts as a gastric cancer oncogene | ZNF703 acts as an oncogene that promotes progression in gastric cancer.
Yang G, Ma F, Zhong M, Fang L, Peng Y, Xin X, Zhong J, Yuan F, Gu H, Zhu W, Zhang Y. | 11/8/2014 |
| High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer. | High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Reynisdottir I, Arason A, Einarsdottir BO, Gunnarsson H, Staaf J, Vallon-Christersson J, Jonsson G, Ringnér M, Agnarsson BA, Olafsdottir K, Fagerholm R, Einarsdottir T, Johannesdottir G, Johannsson OT, Nevanlinna H, Borg A, Barkardottir RB., Free PMC Article | 06/14/2014 |
| Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen. | Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling.
Zhang X, Mu X, Huang O, Xie Z, Jiang M, Geng M, Shen K., Free PMC Article | 04/26/2014 |
| The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein. | Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression.
Pereira-Castro I, Costa AM, Oliveira MJ, Barbosa I, Rocha AS, Azevedo L, da Costa LT. | 04/27/2013 |
| ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells. | ZNF703 gene amplification at 8p12 specifies luminal B breast cancer.
Sircoulomb F, Nicolas N, Ferrari A, Finetti P, Bekhouche I, Rousselet E, Lonigro A, Adélaïde J, Baudelet E, Esteyriès S, Wicinski J, Audebert S, Charafe-Jauffret E, Jacquemier J, Lopez M, Borg JP, Sotiriou C, Popovici C, Bertucci F, Birnbaum D, Chaffanet M, Ginestier C., Free PMC Article | 06/18/2011 |
| These data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer. | ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
Holland DG, Burleigh A, Git A, Goldgraben MA, Perez-Mancera PA, Chin SF, Hurtado A, Bruna A, Ali HR, Greenwood W, Dunning MJ, Samarajiwa S, Menon S, Rueda OM, Lynch AG, McKinney S, Ellis IO, Eaves CJ, Carroll JS, Curtis C, Aparicio S, Caldas C., Free PMC Article | 06/18/2011 |
| Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53. | Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis.
Kwek SS, Roy R, Zhou H, Climent J, Martinez-Climent JA, Fridlyand J, Albertson DG., Free PMC Article | 01/21/2010 |