| TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression. | TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression.
Garcia-Montojo M, Fathi S, Rastegar C, Simula ER, Doucet-O'Hare T, Cheng YHH, Abrams RPM, Pasternack N, Malik N, Bachani M, Disanza B, Maric D, Lee MH, Wang H, Santamaria U, Li W, Sampson K, Lorenzo JR, Sanchez IE, Mezghrani A, Li Y, Sechi LA, Pineda S, Heiman M, Kellis M, Steiner J, Nath A., Free PMC Article | 08/13/2024 |
| ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner. | ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner.
Wang X, Wang Y, Yang L, Yuan J, Shen W, Zhang W, Wang J, Tao K. | 06/30/2023 |
| l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells. | l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells.
Seike M, Asahara SI, Inoue H, Kudo M, Kanno A, Yokoi A, Suzuki H, Kimura-Koyanagi M, Kido Y, Ogawa W. | 03/15/2023 |
| The role of the quaternary structure in the activation of human L-asparaginase. | The role of the quaternary structure in the activation of human L-asparaginase.
Morais SB, Pirolla RAS, Frota NF, Lourenzoni MR, Gozzo FC, Souza TACB. | 07/31/2021 |
| The strongest associations between protein abundance and Alzheimer's disease severity were found for APLP1, CNTN2 and SPP1 proteins The best discrimination between mild cognitive impairment vs. controls was observed with a model combining APLP1 and SPP1 proteins. | Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.
Begcevic I, Brinc D, Brown M, Martinez-Morillo E, Goldhardt O, Grimmer T, Magdolen V, Batruch I, Diamandis EP. | 10/26/2019 |
| ASRGL1 was closely associated with growth and apoptosis in cervical cancer. Therefore, ASRGL1 may be a novel, potentially effective anticervical cancer therapy. | RNAi‑mediated downregulation of asparaginase‑like protein 1 inhibits growth and promotes apoptosis of human cervical cancer line SiHa.
Lv XF, Hong HQ, Liu L, Cui SH, Ren CC, Li HY, Zhang XA, Zhang LD, Wei TX, Liu JJ, Xing WY, Fu H, Yan SJ., Free PMC Article | 10/20/2018 |
| A panel including p53 and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P<0.001) of dying of EEC compared to the low-risk group. | Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.
Huvila J, Laajala TD, Edqvist PH, Mardinoglu A, Talve L, Pontén F, Grénman S, Carpén O, Aittokallio T, Auranen A. | 07/14/2018 |
| In a prospective setting ASRGL1 validates as a strong prognostic biomarker in endometrial carcinoma. Loss of ASRGL1 is associated with aggressive disease and poor survival. | Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions.
Fonnes T, Berg HF, Bredholt T, Edqvist PD, Sortland K, Berg A, Salvesen HB, Akslen LA, Werner HMJ, Trovik J, Tangen IL, Krakstad C. | 06/30/2018 |
| Our studies suggest that the p.G178R mutation in ASRGL1 leads to photoreceptor degeneration resulting in progressive vision loss. | A missense mutation in ASRGL1 is involved in causing autosomal recessive retinal degeneration.
Biswas P, Chavali VR, Agnello G, Stone E, Chakarova C, Duncan JL, Kannabiran C, Homsher M, Bhattacharya SS, Naeem MA, Kimchi A, Sharon D, Iwata T, Riazuddin S, Reddy GB, Hejtmancik JF, Georgiou G, Riazuddin SA, Ayyagari R., Free PMC Article | 07/15/2017 |
| Multiple negatively charged small molecules interact within the active site of ASRGL1 to act as a base in promoting cleavage. | Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.
Li W, Irani S, Crutchfield A, Hodge K, Matthews W, Patel P, Zhang YJ, Stone E., Free PMC Article | 06/28/2016 |
| Reduced expression of ASRGL1, defined as <75% positively stained tumor cells, was significantly associated with poor prognosis and reduced disease-specific survival in endometrioid endometrial adenocarcinoma (EEA). | Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma.
Edqvist PH, Huvila J, Forsström B, Talve L, Carpén O, Salvesen HB, Krakstad C, Grénman S, Johannesson H, Ljungqvist O, Uhlén M, Pontén F, Auranen A. | 09/5/2015 |
| Determined is the structure of the first mammalian plant-type asparaginase in both a precursor and fully activated form. | Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.
Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, Zhang Y., Free PMC Article | 04/20/2013 |
| ASRGL1 exhibits beta-aspartyl peptidase activity consistent with plant-type asparaginases. ASRGL1 is shown to be an Ntn hydrolase for which Thr168 serves as the essential N-terminal nucleophile for intramolecular processing and catalysis. | The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.
Cantor JR, Stone EM, Chantranupong L, Georgiou G., Free PMC Article | 01/21/2010 |
| Overexpression of CRASH is associated with metastatic breast cancer. | Cell growth stimulation by CRASH, an asparaginase-like protein overexpressed in human tumors and metastatic breast cancers.
Weidle UH, Evtimova V, Alberti S, Guerra E, Fersis N, Kaul S. | 01/21/2010 |
| Human ALP cDNA was subsequently cloned. It showed 77% identity to the rat ALP sequence and the gene, ASRGL1 (asparaginase-like 1), mapped to chromosome locus 11q12.3. | A novel asparaginase-like protein is a sperm autoantigen in rats.
Bush LA, Herr JC, Wolkowicz M, Sherman NE, Shore A, Flickinger CJ. | 01/21/2010 |