| FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA. | FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
Kasuga Y, Ouda R, Watanabe M, Sun X, Kimura M, Hatakeyama S, Kobayashi KS., Free PMC Article | 06/9/2023 |
| FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins. | FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins.
Jeon Y, Chow SH, Stuart I, Weir A, Yeung AT, Hale C, Sridhar S, Dougan G, Vince JE, Naderer T., Free PMC Article | 04/4/2023 |
| FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3-TBK1-IRF3 complex. | FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3-TBK1-IRF3 complex.
Gao L, Gao Y, Han K, Wang Z, Meng F, Liu J, Zhao X, Shao Y, Shen J, Sun W, Liu Y, Xu H, Du X, Li J, Qin FX. | 03/30/2023 |
| Ultrasound-targeted microbubble destruction-mediated silencing of FBXO11 suppresses development of pancreatic cancer. | Ultrasound-targeted microbubble destruction-mediated silencing of FBXO11 suppresses development of pancreatic cancer.
Xue J, Chen S, Ge D, Yuan X. | 07/2/2022 |
| De novo missense variants in FBXO11 alter its protein expression and subcellular localization. | De novo missense variants in FBXO11 alter its protein expression and subcellular localization.
Gregor A, Meerbrei T, Gerstner T, Toutain A, Lynch SA, Stals K, Maxton C, Lemke JR, Bernat JA, Bombei HM, Foulds N, Hunt D, Kuechler A, Beygo J, Stöbe P, Bouman A, Palomares-Bralo M, Santos-Simarro F, Garcia-Minaur S, Pacio-Miguez M, Popp B, Vasileiou G, Hebebrand M, Reis A, Schuhmann S, Krumbiegel M, Brown NJ, Sparber P, Melikyan L, Bessonova L, Cherevatova T, Sharkov A, Shcherbakova N, Dabir T, Kini U, Schwaibold EMC, Haack TB, Bertoli M, Hoffjan S, Falb R, Shinawi M, Sticht H, Zweier C., Free PMC Article | 05/7/2022 |
| Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma. | Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
Pighi C, Cheong TC, Compagno M, Patrucco E, Arigoni M, Olivero M, Wang Q, López C, Bernhart SH, Grande BM, Poggio T, Langellotto F, Bonello L, Dall'Olio R, Martínez-Martín S, Molinaro L, Francia di Celle P, Whitfield JR, Soucek L, Voena C, Calogero RA, Morin RD, Staudt LM, Siebert R, Zamò A, Chiarle R., Free PMC Article | 01/15/2022 |
| The first familial case of inherited intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (IDDFBA) with a novel FBXO11 variant. | The first familial case of inherited intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (IDDFBA) with a novel FBXO11 variant.
Lee CG, Seol CA, Ki CS. | 06/26/2021 |
| FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome. | FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome.
Schieber M, Marinaccio C, Bolanos LC, Haffey WD, Greis KD, Starczynowski DT, Crispino JD., Free PMC Article | 05/8/2021 |
| FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis. | FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis.
Xu P, Scott DC, Xu B, Yao Y, Feng R, Cheng L, Mayberry K, Wang YD, Bi W, Palmer LE, King MT, Wang H, Li Y, Fan Y, Alpi AF, Li C, Peng J, Papizan J, Pruett-Miller SM, Spallek R, Bassermann F, Cheng Y, Schulman BA, Weiss MJ., Free PMC Article | 04/24/2021 |
| Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. | Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis.
Mei J, Zhang Y, Lu S, Wang J. | 02/27/2021 |
| 24 individuals with a de novo disease-causing variant in, or partial deletion of, the F-box only protein 11 gene, are reported. | De novo variants in FBXO11 cause a syndromic form of intellectual disability with behavioral problems and dysmorphisms.
Jansen S, van der Werf IM, Innes AM, Afenjar A, Agrawal PB, Anderson IJ, Atwal PS, van Binsbergen E, van den Boogaard MJ, Castiglia L, Coban-Akdemir ZH, van Dijck A, Doummar D, van Eerde AM, van Essen AJ, van Gassen KL, Guillen Sacoto MJ, van Haelst MM, Iossifov I, Jackson JL, Judd E, Kaiwar C, Keren B, Klee EW, Klein Wassink-Ruiter JS, Meuwissen ME, Monaghan KG, de Munnik SA, Nava C, Ockeloen CW, Pettinato R, Racher H, Rinne T, Romano C, Sanders VR, Schnur RE, Smeets EJ, Stegmann APA, Stray-Pedersen A, Sweetser DA, Terhal PA, Tveten K, VanNoy GE, de Vries PF, Waxler JL, Willing M, Pfundt R, Veltman JA, Kooy RF, Vissers LELM, de Vries BBA., Free PMC Article | 06/13/2020 |
| FBXO11 expression was closely related to renal cell carcinoma malignancy and poor prognosis, indicating its potential as a prognostic marker as well as a therapeutic target for renal cell carcinoma. | Prevalence and prognostic value of FBXO11 expression in patients with clear cell renal cell carcinoma.
Fan B, Wang W, Zhang X, Sun M, Wang X, Chen Z, Liu W, Wang Q, Yu N, Li X., Free PMC Article | 12/14/2019 |
| Chronic otitis media is associated with the TGIF1 and FBXO11 loci that are involved in TGF-beta signaling, suggesting this pathway may be important in the transition from acute to chronic middle ear inflammation, and a potential molecular target. | A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11.
Bhutta MF, Lambie J, Hobson L, Goel A, Hafrén L, Einarsdottir E, Mattila PS, Farrall M, Brown S, Burton MJ., Free PMC Article | 07/20/2019 |
| Eight missense variants distributed throughout FBXO11. | De Novo Variants in the F-Box Protein FBXO11 in 20 Individuals with a Variable Neurodevelopmental Disorder.
Gregor A, Sadleir LG, Asadollahi R, Azzarello-Burri S, Battaglia A, Ousager LB, Boonsawat P, Bruel AL, Buchert R, Calpena E, Cogné B, Dallapiccola B, Distelmaier F, Elmslie F, Faivre L, Haack TB, Harrison V, Henderson A, Hunt D, Isidor B, Joset P, Kumada S, Lachmeijer AMA, Lees M, Lynch SA, Martinez F, Matsumoto N, McDougall C, Mefford HC, Miyake N, Myers CT, Moutton S, Nesbitt A, Novelli A, Orellana C, Rauch A, Rosello M, Saida K, Santani AB, Sarkar A, Scheffer IE, Shinawi M, Steindl K, Symonds JD, Zackai EH, University of Washington Center for Mendelian Genomics, DDD Study, Reis A, Sticht H, Zweier C., Free PMC Article | 05/18/2019 |
| we confirm deleterious de novo mutations in FBXO11 as a cause of Intellectual disability and start the delineation of the associated clinical picture which may also comprise postnatal microcephaly or borderline small head size and behavioural anomalies. | De novo FBXO11 mutations are associated with intellectual disability and behavioural anomalies.
Fritzen D, Kuechler A, Grimmel M, Becker J, Peters S, Sturm M, Hundertmark H, Schmidt A, Kreiß M, Strom TM, Wieczorek D, Haack TB, Beck-Wödl S, Cremer K, Engels H. | 03/30/2019 |
| High expression of FBXO11 predicted a poor survival of hepatocellular carcinoma patients. | The tumor suppressive miR-26a regulation of FBXO11 inhibits proliferation, migration and invasion of hepatocellular carcinoma cells.
Ma Y, Deng F, Li P, Chen G, Tao Y, Wang H. | 09/29/2018 |
| Understanding of the functions of FBXO11. | F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT.
Sun C, Tao Y, Gao Y, Xia Y, Liu Y, Wang G, Gu Y. | 08/18/2018 |
| FBXO11 is a direct target of miR-621 in breast cancer cells. | MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity.
Xue J, Chi Y, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer LM, Shao ZM, Wu ZH, Wu J., Free PMC Article | 06/28/2016 |
| UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway. | Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.
Zhao C, Wang L, Ma X, Zhu W, Yao L, Cui Y, Liu Y, Li J, Liang X, Sun Y, Li L, Chen YH., Free PMC Article | 04/16/2016 |
| siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not. | FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.
Ju UI, Park JW, Park HS, Kim SJ, Chun YS. | 12/12/2015 |
| Our results identify FBXO11 as a novel miR-21 target gene, and demonstrate that the oncogenic miRNA miR-21 decreases the expression of FBXO11, which normally acts as a tumor suppressor, and thereby promotes tumorigenesis. | The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis.
Yang CH, Pfeffer SR, Sims M, Yue J, Wang Y, Linga VG, Paulus E, Davidoff AM, Pfeffer LM., Free PMC Article | 05/23/2015 |
| study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A. | Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.
Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC., Free PMC Article | 04/4/2015 |
| The PKD1-FBXO11-SNAIL axis is a mechanism of posttranslational regulation of epithelial-mesenchymal transition and cancer metastasis. | PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.
Zheng H, Shen M, Zha YL, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang HY, Kang Y., Free PMC Article | 11/22/2014 |
| TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. | Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.
Abbas T, Keaton M, Dutta A., Free PMC Article | 03/8/2014 |
| Migration of epithelial cells is stimulated by CRL1(FBXO11)-mediated downregulation of Cdt2 and the consequent stabilization of Set8. | CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.
Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A., Free PMC Article | 05/25/2013 |