| CDK5RAP3 is a novel super-enhancer-driven gene activated by master TFs and regulates ER-Phagy in neuroblastoma. | CDK5RAP3 is a novel super-enhancer-driven gene activated by master TFs and regulates ER-Phagy in neuroblastoma.
Zhuo R, Zhang Z, Chen Y, Li G, Du S, Guo X, Yang R, Tao Y, Li X, Fang F, Xie Y, Wu D, Yang Y, Yang C, Yin H, Qian G, Wang H, Yu J, Jia S, Zhu F, Feng C, Wang J, Xu Y, Li Z, Shi L, Wang X, Pan J, Wang J. | 08/5/2024 |
| TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway. | TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway.
Zhang C, Du FH, Wang RX, Han WB, Lv X, Zeng LH, Chen GQ., Free PMC Article | 06/13/2024 |
| CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages. | CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.
Wang JB, Gao YX, Ye YH, Lin TX, Li P, Lin JX, Chen QY, Cao LL, Lin M, Tu RH, Lin JL, Huang ZN, Zheng HL, Xie JW, Zheng CH, Huang CM., Free PMC Article | 01/21/2023 |
| CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3beta/Wnt/beta-catenin signaling. | CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.
Feng X, Jiang J, Sun L, Zhou Q. | 05/14/2022 |
| CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer. | CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer.
Lin JX, Yoon C, Li P, Ryeom SW, Cho SJ, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Yoon SS, Huang CM., Free PMC Article | 03/27/2021 |
| The current findings advance innovation in drug discovery and highlight C53 as a novel pGC-B activator with sustained in vivo activity and anti-fibrotic actions in vitro. | C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.
Chen Y, Zheng Y, Iyer SR, Harders GE, Pan S, Chen HH, Ichiki T, Burnett JC Jr, Sangaralingham SJ., Free PMC Article | 06/20/2020 |
| CDK5RAP3 is associated with autophagy and down-regulated in renal cancer. | CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer.
Li J, Hu X, Su M, Shen H, Qiu W, Tian Y., Free PMC Article | 08/31/2019 |
| Study demonstrated that CDK5RAP3/C53 isoform d (IC53d) was upregulated in gastric cancer tissues and was associated with tumor Tstage. Furthermore, overexpression of IC53d promoted the proliferation, colony formation and G1/S phase transition of gastric cancer cells, leading to enhancement of tumorigenesis in vitro and in vivo. | Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.
Lin JX, Xie XS, Weng XF, Qiu SL, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM, Zheng CH., Free PMC Article | 07/6/2019 |
| Our results demonstrated that CDK5RAP3 negatively regulates the Wnt/beta-catenin signaling pathway by repressing AKT phosphorylation, which leads to better survival of patients with gastric cancer. | CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.
Zheng CH, Wang JB, Lin MQ, Zhang PY, Liu LC, Lin JX, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Xie JW, Li P, Huang CM., Free PMC Article | 05/11/2019 |
| Prognostic analysis showed that the co-expression of CDK5RAP3 and DDRGK1 was an independent prognostic factor correlating with the overall survival of gastric cancer patients. | Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
Lin JX, Xie XS, Weng XF, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM., Free PMC Article | 11/17/2018 |
| CDK5RAP3 negatively regulates the beta-catenin signaling pathway by repressing GSK-3beta phosphorylation in gastric neoplasms. | CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
Wang JB, Wang ZW, Li Y, Huang CQ, Zheng CH, Li P, Xie JW, Lin JX, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Lin Y, Huang CM. | 08/12/2017 |
| C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture. | Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope.
Wu J, Jiang H, Luo S, Zhang M, Zhang Y, Sun F, Huang S, Li H., Free PMC Article | 11/30/2013 |
| our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF). | CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.
Mak GW, Lai WL, Zhou Y, Li M, Ng IO, Ching YP., Free PMC Article | 01/26/2013 |
| LZAP may play an important role in hepatocellular carcinoma progression | Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma.
Zhao JJ, Pan K, Li JJ, Chen YB, Chen JG, Lv L, Wang DD, Pan QZ, Chen MS, Xia JC., Free PMC Article | 02/25/2012 |
| our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response | Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma.
Lei Y, Liu H, Yang Y, Wang X, Ren N, Li B, Liu S, Cheng J, Fu X, Zhang J. | 02/18/2012 |
| Data indicate that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer. | A functional variant of IC53 correlates with the late onset of colorectal cancer.
Chen J, Shi Y, Li Z, Yu H, Han Y, Wang X, Sun K, Yang T, Lou K, Song Y, Zhang Y, Zhen Y, Zhang G, Hu Y, Ji J, Hui R., Free PMC Article | 12/31/2011 |
| Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage | Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
Hořejší B, Vinopal S, Sládková V, Dráberová E, Sulimenko V, Sulimenko T, Vosecká V, Philimonenko A, Hozák P, Katsetos CD, Dráber P. | 12/10/2011 |
| the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1 | LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
An H, Lu X, Liu D, Yarbrough WG., Free PMC Article | 08/6/2011 |
| Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation. | Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.
Mak GW, Chan MM, Leong VY, Lee JM, Yau TO, Ng IO, Ching YP. | 07/16/2011 |
| found that C53/LZAP and DDRGK1 became more susceptible to the proteasome-mediated degradation in RCAD knockdown cells, whereas their ubiquitination was significantly attenuated by RCAD overexpression | A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.
Wu J, Lei G, Mei M, Tang Y, Li H., Free PMC Article | 06/28/2010 |
| Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. | Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice.
Zhuo ML, Huang Y, Chen JZ, Sun LH, Yang RF, Chen HZ, Lv X, Li HL, Wei YS, Liu G, Zhang R, Ma TM, Cai H, Hui RT, Liu DP, Liang CC., Free PMC Article | 01/21/2010 |
| CDK5 regulatory subunit associated protein 3 promotes checkpoint kinase 1 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response. | Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.
Jiang H, Wu J, He C, Yang W, Li H., Free PMC Article | 01/21/2010 |
| it is concluded that CDK5RAP3, CCNB2, and RAGE genes may be used as a very reliable biomarkers of lung adenocarcinoma | Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma.
Stav D, Bar I, Sandbank J. | 01/21/2010 |
| LZAP has a role in NF-kappaB regulation and tumor suppression. | LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG. | 01/21/2010 |
| IC53 is a novel gene, mainly expressed in vascular endothelial cells and mediates cell proliferation | A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.
Chen J, Liu B, Liu Y, Han Y, Yu H, Zhang Y, Lu L, Zhen Y, Hui R. | 01/21/2010 |