| NCOA4 requires a [3Fe-4S] to sense and maintain the iron homeostasis. | NCOA4 requires a [3Fe-4S] to sense and maintain the iron homeostasis.
Zhao H, Lu Y, Zhang J, Sun Z, Cheng C, Liu Y, Wu L, Zhang M, He W, Hao S, Li K., Free PMC Article | 02/28/2024 |
| HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350. | HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350.
Lin Y, Gong H, Liu J, Hu Z, Gao M, Yu W, Liu J., Free PMC Article | 12/6/2023 |
| JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. | JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
Sun K, Hou L, Guo Z, Wang G, Guo J, Xu J, Zhang X, Guo F. | 05/23/2023 |
| RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients. | RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients.
Khonrak T, Watcharadetwittaya S, Chamgramol Y, Intarawichian P, Deenonpoe R., Free PMC Article | 05/20/2023 |
| The PTBP1NCOA4 axis promotes ferroptosis in liver cancer cells. | The PTBP1‑NCOA4 axis promotes ferroptosis in liver cancer cells.
Yang H, Sun W, Bi T, Wang Q, Wang W, Xu Y, Liu Z, Li J., Free PMC Article | 01/28/2023 |
| C-MYC Inhibited Ferroptosis and Promoted Immune Evasion in Ovarian Cancer Cells through NCOA4 Mediated Ferritin Autophagy. | C-MYC Inhibited Ferroptosis and Promoted Immune Evasion in Ovarian Cancer Cells through NCOA4 Mediated Ferritin Autophagy.
Jin Y, Qiu J, Lu X, Li G., Free PMC Article | 01/11/2023 |
| TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells. | TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.
Li K, Chen B, Xu A, Shen J, Li K, Hao K, Hao R, Yang W, Jiang W, Zheng Y, Ge F, Wang Z., Free PMC Article | 10/8/2022 |
| NCOA4-Mediated Ferroptosis in Bronchial Epithelial Cells Promotes Macrophage M2 Polarization in COPD Emphysema. | NCOA4-Mediated Ferroptosis in Bronchial Epithelial Cells Promotes Macrophage M2 Polarization in COPD Emphysema.
Liu J, Zhang Z, Yang Y, Di T, Wu Y, Bian T., Free PMC Article | 04/16/2022 |
| Intraductal carcinoma of the salivary gland with NCOA4-RET: expanding the morphologic spectrum and an algorithmic diagnostic approach. | Intraductal carcinoma of the salivary gland with NCOA4-RET: expanding the morphologic spectrum and an algorithmic diagnostic approach.
Fisch AS, Laklouk I, Nakaguro M, Nosé V, Wirth LJ, Deschler DG, Faquin WC, Dias-Santagata D, Sadow PM., Free PMC Article | 01/1/2022 |
| The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis. | The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis.
Santana-Codina N, Gikandi A, Mancias JD. | 08/14/2021 |
| Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. | Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines.
Zhang Y, Kong Y, Ma Y, Ni S, Wikerholmen T, Xi K, Zhao F, Zhao Z, Wang J, Huang B, Chen A, Yao Z, Han M, Feng Z, Hu Y, Thorsen F, Wang J, Li X., Free PMC Article | 07/31/2021 |
| Nuclear receptor coactivator 4-mediated ferritinophagy drives proliferation of dental pulp stem cells in hypoxia. | Nuclear receptor coactivator 4-mediated ferritinophagy drives proliferation of dental pulp stem cells in hypoxia.
Yang A, Wang L, Jiang K, Lei L, Li H. | 07/17/2021 |
| Ferritinophagy is not required for colon cancer cell growth. | Ferritinophagy is not required for colon cancer cell growth.
Hasan M, Reddy SM, Das NK. | 06/26/2021 |
| NCOA4-mediated ferritinophagy promoted inflammatory responses in periodontitis. | NCOA4-mediated ferritinophagy promoted inflammatory responses in periodontitis.
Guo W, Zhao Y, Li H, Lei L. | 05/22/2021 |
| Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma. | Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma.
Mou Y, Wu J, Zhang Y, Abdihamid O, Duan C, Li B., Free PMC Article | 05/15/2021 |
| Thermodynamic and Kinetic Studies of the Interaction of Nuclear Receptor Coactivator-4 (NCOA4) with Human Ferritin. | Thermodynamic and Kinetic Studies of the Interaction of Nuclear Receptor Coactivator-4 (NCOA4) with Human Ferritin.
Srivastava AK, Flint N, Kreckel H, Gryzik M, Poli M, Arosio P, Bou-Abdallah F. | 03/13/2021 |
| Tumor-type-specific NCOA4-RET or TRIM27-RET translocations are found in a subset of widely invasive salivary carcinomas with intercalated duct-like immunoprofiles. | NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is "Intraductal" Correct?
Skálová A, Ptáková N, Santana T, Agaimy A, Ihrler S, Uro-Coste E, Thompson LDR, Bishop JA, Baněčkova M, Rupp NJ, Morbini P, de Sanctis S, Schiavo-Lena M, Vanecek T, Michal M, Leivo I. | 04/11/2020 |
| Study showed that NCOA4-mediated ferritin complex degradation supplies iron to mitochondria. | Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.
Fujimaki M, Furuya N, Saiki S, Amo T, Imamichi Y, Hattori N., Free PMC Article | 02/1/2020 |
| NCOA4-RET as the dominant fusion in intercalated duct type salivary gland intraductal carcinoma. | Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions: A Report of 17 cases.
Skálová A, Vanecek T, Uro-Coste E, Bishop JA, Weinreb I, Thompson LDR, de Sanctis S, Schiavo-Lena M, Laco J, Badoual C, Santana Conceiçao T, Ptáková N, Baněčkova M, Miesbauerová M, Michal M. | 09/7/2019 |
| the actions of PCBP1 and NCOA4 on ferritin allow erythroid cells to rapidly respond to changes in cellular iron availability, which could provide a strategy to maintain cellular iron storage and utilization at a constant rate despite fluctuation in the total cellular iron supply. | Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.
Ryu MS, Duck KA, Philpott CC., Free PMC Article | 03/16/2019 |
| Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. | Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF., Free PMC Article | 06/9/2018 |
| The H-ferritin could bind up to 24 NCOA4(383-522) fragments forming highly stable and insoluble complexes. The binding was partially inhibited only by Fe(II) among the various divalent metal ions analyzed. The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy. | Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4).
Gryzik M, Srivastava A, Longhi G, Bertuzzi M, Gianoncelli A, Carmona F, Poli M, Arosio P. | 02/10/2018 |
| the ATG5-ATG7-NCOA4 autophagic pathway has a role in ferroptosis | Autophagy promotes ferroptosis by degradation of ferritin.
Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd, Kang R, Tang D., Free PMC Article | 01/6/2018 |
| Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase. | Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW., Free PMC Article | 07/2/2016 |
| Studies indicate nuclear receptor coactivator 4 (NcoA4) as a coactivator for a variety of nuclear receptors. | Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity.
Kollara A, Brown TJ., Free PMC Article | 11/21/2015 |