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    PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens (human) ]

    Gene ID: 80380, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy.

    PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy.
    Wang S, Su D, Chen H, Lai JC, Tang C, Li Y, Wang Y, Yang Y, Qin M, Jia L, Cui W, Yang J, Wang L, Wu C.,

    09/10/2024
    Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2 evade innate and adaptive immunity.

    Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2 evade innate and adaptive immunity.
    Tsuneyoshi N, Hosoya T, Takeno Y, Saitoh K, Murai H, Amimoto N, Tatsumi R, Watanabe S, Hasegawa Y, Kikkawa E, Goto K, Nishigaki F, Tamura K, Kimura H., Free PMC Article

    07/25/2024
    An alternatively spliced PD-L1 isoform PD-L13, and PD-L2 expression in breast cancers: implications for eligibility scoring and immunotherapy response.

    An alternatively spliced PD-L1 isoform PD-L1∆3, and PD-L2 expression in breast cancers: implications for eligibility scoring and immunotherapy response.
    Dioken DN, Ozgul I, Yilmazbilek I, Yakicier MC, Karaca E, Erson-Bensan AE., Free PMC Article

    12/15/2023
    PD-L2 overexpression on tumor-associated macrophages is one of the predictors for better prognosis in lung adenocarcinoma.

    PD-L2 overexpression on tumor-associated macrophages is one of the predictors for better prognosis in lung adenocarcinoma.
    Matsubara E, Shinchi Y, Komohara Y, Yano H, Pan C, Fujiwara Y, Ikeda K, Suzuki M.

    11/20/2023
    Cholinergic signaling influences the expression of immune checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in human colorectal cancer tissues and cell lines.

    Cholinergic signaling influences the expression of immune checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in human colorectal cancer tissues and cell lines.
    Kuol N, Godlewski J, Kmiec Z, Vogrin S, Fraser S, Apostolopoulos V, Nurgali K., Free PMC Article

    11/18/2023
    Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment.

    Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment.
    Lv J, Jiang Z, Yuan J, Zhuang M, Guan X, Liu H, Yin Y, Ma Y, Liu Z, Wang H, Wang X., Free PMC Article

    08/10/2023
    PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells.

    PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells.
    Larsen TV, Daugaard TF, Gad HH, Hartmann R, Nielsen AL.

    06/15/2023
    The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes.

    The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes.
    Atılgan AO, Tepeoğlu M, Özen Ö, Reyhan ANH, Ayhan A.

    05/22/2023
    The Overexpression of Programmed Death-Ligand 2 in Uterine Adenosarcoma: Correlation with High-Grade Morphology, Mutant Type TP53 Expression and Clinical Outcomes.

    The Overexpression of Programmed Death-Ligand 2 in Uterine Adenosarcoma: Correlation with High-Grade Morphology, Mutant Type TP53 Expression and Clinical Outcomes.
    Ok Atılgan A, Yılmaz Akçay E, Özen Ö, Haberal Reyhan AN, Ayhan A.

    05/12/2023
    Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy.

    Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy.
    Wang Y, Du J, Gao Z, Sun H, Mei M, Wang Y, Ren Y, Zhou X., Free PMC Article

    03/30/2023
    Expression of Programmed Cell Death 1 Ligand 2 in Patients With Thymoma and Thymomatous Myasthenia Gravis.

    Expression of Programmed Cell Death 1 Ligand 2 in Patients With Thymoma and Thymomatous Myasthenia Gravis.
    Zhu H, Zou J, Zeng B, Yang L, Xiao J, Zhang X, Feng Y, Su C.

    03/14/2023
    Expression of IDO1 and PD-L2 in Patients with Benign Lymphadenopathies and Association with Autoimmune Diseases.

    Expression of IDO1 and PD-L2 in Patients with Benign Lymphadenopathies and Association with Autoimmune Diseases.
    Abdulla M, Sundström C, Lindskog C, Hollander P., Free PMC Article

    03/1/2023
    Programmed cell death 1 and programmed cell death ligand 1 expression in invasive breast carcinoma using CAL10 and NAT105 immunostaining.

    Programmed cell death 1 and programmed cell death ligand 1 expression in invasive breast carcinoma using CAL10 and NAT105 immunostaining.
    Durak Ö, Bozkurt KK, Çiriş İM, Kocer M, Eroğlu HE.

    02/11/2023
    PD-L1 and PD-L2 expression in colorectal cancer.

    PD-L1 and PD-L2 expression in colorectal cancer.
    Zeynep O, Funda C, Evrim Y, Deniz A, Bülent Y, Fatih YN.

    01/28/2023
    Investigation of pd-l1 (cd274), pd-l2 (pdcd1lg2), and ctla-4 expressions in malignant pleural mesothelioma by immunohistochemistry and real-time polymerase chain reaction methods.

    Investigation of pd-l1 (cd274), pd-l2 (pdcd1lg2), and ctla-4 expressions in malignant pleural mesothelioma by immunohistochemistry and real-time polymerase chain reaction methods.
    Sule Kutlar Dursun F, Alabalik U.

    11/19/2022
    FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer.

    FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer.
    Davidson C, Taggart D, Sims AH, Lonergan DW, Canel M, Serrels A., Free PMC Article

    11/19/2022
    Exome sequencing identifies PD-L2 as a potential predisposition gene for lymphoma.

    Exome sequencing identifies PD-L2 as a potential predisposition gene for lymphoma.
    Shao J, Gao L, Leung ML, Gallinger B, Inglese C, Meyn MS, Del Gaudio D, Das S, Li Z., Free PMC Article

    08/13/2022
    Clinical relevance of PD-L2 expression in surgically resected lung adenocarcinoma.

    Clinical relevance of PD-L2 expression in surgically resected lung adenocarcinoma.
    Takamochi K, Hara K, Hayashi T, Kohsaka S, Takahashi F, Suehara Y, Shimokawa M, Suzuki K.

    06/11/2022
    PD-L1 and PD-L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules.

    PD-L1 and PD-L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules.
    Zhang Y, Chen X, Mo S, Ma H, Lu Z, Yu S, Chen J., Free PMC Article

    04/16/2022
    DNA Methylation Patterns in the HLA-DPB1 and PDCD1LG2 Gene Regions in Patients with Autoimmune Thyroiditis from Different Water Iodine Areas.

    DNA Methylation Patterns in the HLA-DPB1 and PDCD1LG2 Gene Regions in Patients with Autoimmune Thyroiditis from Different Water Iodine Areas.
    Wan S, Liu L, Ren B, Qu M, Wu H, Jiang W, Wang X, Shen H.

    03/19/2022
    The role of PD-1/PD-Ls in the pathogenesis of IgG4-related disease.

    The role of PD-1/PD-Ls in the pathogenesis of IgG4-related disease.
    Zhang X, Lu H, Peng L, Zhou J, Wang M, Li J, Liu Z, Zhang W, Zhao Y, Zeng X, Lu L.

    03/12/2022
    Differential expression of PDL1 and PDL2 is associated with the tumor microenvironment of TILs and M2 TAMs and tumor differentiation in nonsmall cell lung cancer.

    Differential expression of PD‑L1 and PD‑L2 is associated with the tumor microenvironment of TILs and M2 TAMs and tumor differentiation in non‑small cell lung cancer.
    Sumitomo R, Huang CL, Fujita M, Cho H, Date H., Free PMC Article

    02/19/2022
    Inhibition of PI3Kdelta Differentially Regulates Poly I:C- and Human Metapneumovirus-Induced PD-L1 and PD-L2 Expression in Human Bronchial Epithelial Cells.

    Inhibition of PI3Kδ Differentially Regulates Poly I:C- and Human Metapneumovirus-Induced PD-L1 and PD-L2 Expression in Human Bronchial Epithelial Cells.
    Ogawa T, Kan-O K, Shiota A, Fujita A, Ishii Y, Fukuyama S, Matsumoto K., Free PMC Article

    02/19/2022
    PD-L1 and PD-L2 Mutations in Pediatric Hodgkin Lymphoma: Do They Have Any Prognostic Significance?

    PD-L1 and PD-L2 Mutations in Pediatric Hodgkin Lymphoma: Do They Have Any Prognostic Significance?
    Gül G, Ince D, Olgun N, Ozer E.

    02/12/2022
    Molecular and Immune Correlates of PDCD1 (PD-1), PD-L1 (CD274), and PD-L2 (PDCD1LG2) DNA Methylation in Triple Negative Breast Cancer.

    Molecular and Immune Correlates of PDCD1 (PD-1), PD-L1 (CD274), and PD-L2 (PDCD1LG2) DNA Methylation in Triple Negative Breast Cancer.
    Ralser DJ, Klümper N, Gevensleben H, Zarbl R, Kaiser C, Landsberg J, Hölzel M, Strieth S, Faridi A, Abramian A, Dietrich D.

    02/5/2022
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