| Knocking out FAM20C in pre-osteoblasts leads to up-regulation of osteoclast differentiation to affect long bone development. | Knocking out FAM20C in pre-osteoblasts leads to up-regulation of osteoclast differentiation to affect long bone development.
Jiang L, Liu X, Liu L, Su L, Lu Z, Zhang H, Guo Y, Zhang W, Zhang S, Xu W, Zhang J, Zhang K, Zhan Y, Xie X, Li R, Dong X, Jin H, Zhang B, Li Y. | 05/9/2024 |
| Mutations of family with sequence similarity 20-member C gene causing lethal and nonlethal Raine syndrome causes hypophosphatemia rickets. | Mutations of family with sequence similarity 20-member C gene causing lethal and nonlethal Raine syndrome causes hypophosphatemia rickets.
Liu P, Li J, Tang L, Cong W, Jin H, Zhang H, Cui B, Yang S, Xiao J, Liu C, Saiyin W. | 11/22/2023 |
| Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation. | Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation.
Naniwa K, Hirose K, Usami Y, Hata K, Araki R, Uzawa N, Komori T, Toyosawa S. | 08/11/2023 |
| Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome. | Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome.
Zhang H, Lu Y, Kramer PR, Benson MD, Cheng YL, Qin C. | 03/28/2023 |
| Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia. | Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia.
Koike T, Mikami T, Tamura JI, Kitagawa H., Free PMC Article | 01/11/2023 |
| FAM20C plays a critical role in the development of mouse vertebra. | FAM20C plays a critical role in the development of mouse vertebra.
Huang Y, Chen H, Zhang H, Lu Y, Qin C. | 04/2/2022 |
| Fam20C Regulates Bone Resorption and Breast Cancer Bone Metastasis through Osteopontin and BMP4. | Fam20C Regulates Bone Resorption and Breast Cancer Bone Metastasis through Osteopontin and BMP4.
Zuo H, Yang D, Wan Y. | 01/8/2022 |
| Ablation of Fam20c causes amelogenesis imperfecta via inhibiting Smad dependent BMP signaling pathway. | Ablation of Fam20c causes amelogenesis imperfecta via inhibiting Smad dependent BMP signaling pathway.
Liu J, Saiyin W, Xie X, Mao L, Li L., Free PMC Article | 08/14/2021 |
| Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice. | Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice.
Zhang H, Xu Q, Lu Y, Qin C., Free PMC Article | 07/17/2021 |
| Overexpression of Fam20C in osteoblast in vivo leads to increased cortical bone formation and osteoclastic bone resorption. | Overexpression of Fam20C in osteoblast in vivo leads to increased cortical bone formation and osteoclastic bone resorption.
Hirose K, Ishimoto T, Usami Y, Sato S, Oya K, Nakano T, Komori T, Toyosawa S. | 07/3/2021 |
| Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia. | Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
Kang T, Boland BB, Alarcon C, Grimsby JS, Rhodes CJ, Larsen MR. | 08/15/2020 |
| OPN, besides being overexpressed in hepatic stellate cells, is substantially phosphorylated by family with sequence similarity 20, member C (Fam20C), formerly known as Golgi casein kinase (G-CK), which is exclusively resident in the Golgi apparatus | Fam20C-mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis.
Tibaldi E, Brocca A, Sticca A, Gola E, Pizzi M, Bordin L, Pagano MA, Mazzorana M, Donà G, Violi P, Marin O, Romano A, Angeli P, Carraro A, Brunati AM. | 07/25/2020 |
| FAM20C is a key regulator of acinar and duct structure and duct maturation. | Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice.
Miao N, Zhan Y, Xu Y, Yuan H, Qin C, Lin F, Xie X, Mu S, Yuan M, Mu H, Guo S, Li Y, Zhang B., Free PMC Article | 08/3/2019 |
| These findings indicate that inactivation of Fam20C in cells expressing type I collagen led to skeletal defects and hypophosphatemia. | Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.
Liu P, Ma S, Zhang H, Liu C, Lu Y, Chen L, Qin C., Free PMC Article | 06/8/2019 |
| we show that Fam20C phosphorylates several SR proteins involved in Ca(2+) signaling, including calsequestrin2 and Stim1, whose biochemical activities are dramatically regulated by Fam20C mediated phosphorylation | A secretory pathway kinase regulates sarcoplasmic reticulum Ca(2+) homeostasis and protects against heart failure.
Pollak AJ, Liu C, Gudlur A, Mayfield JE, Dalton ND, Gu Y, Chen J, Heller Brown J, Hogan PG, Wiley SE, Peterson KL, Dixon JE., Free PMC Article | 03/30/2019 |
| that Fam20c indeed regulates cell behaviors and cell signaling pathway in a cell-autonomous manner | Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.
Liu C, Zhou N, Wang Y, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C., Free PMC Article | 11/17/2018 |
| family with sequence similarity member 20C is the primary, but not the only, kinase for the SIBLINGs | Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone.
Yang X, Yan W, Tian Y, Ma P, Opperman LA, Wang X., Free PMC Article | 06/11/2016 |
| Fam20A potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro. | A secretory kinase complex regulates extracellular protein phosphorylation.
Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M, Dixon JE., Free PMC Article | 01/16/2016 |
| Loss of Fam20C function leads to periodontal disease in mice | Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.
Liu P, Zhang H, Liu C, Wang X, Chen L, Qin C., Free PMC Article | 12/12/2015 |
| Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis | Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice.
Du EX, Wang XF, Yang WC, Kaback D, Yee SP, Qin CL, George A, Hao JJ., Free PMC Article | 11/7/2015 |
| we have successfully generated the immortalized mouse floxed Fam20c dental papilla mesenchymal and osteoblast cell lines. | Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.
Liu C, Wang X, Zhang H, Xie X, Liu P, Liu Y, Jani PH, Lu Y, Chen S, Qin C., Free PMC Article | 10/17/2015 |
| These results indicated that the downregulation of Dmp1 may not directly associate with, or significantly contribute to the bone and dentin defects in the Fam20C-cKO mice. | Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice.
Wang X, Wang J, Yuan B, Lu Y, Feng JQ, Qin C., Free PMC Article | 02/21/2015 |
| that FAM20C is not a constituent of the enamel extracellular matrix and functions intracellularly within ameloblasts. | FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo.
Wang SK, Samann AC, Hu JC, Simmer JP., Free PMC Article | 06/28/2014 |
| FAM20C is a molecule essential to amelogenesis, its inactivation in the dental epithelium does not significantly affect dentinogenesis. | The specific role of FAM20C in amelogenesis.
Wang X, Jung J, Liu Y, Yuan B, Lu Y, Feng JQ, Qin C., Free PMC Article | 12/14/2013 |
| FAM20C is essential to the differentiation and mineralization of dental tissues through the regulation of molecules critical to the differentiation of tooth-formative cells. | FAM20C plays an essential role in the formation of murine teeth.
Wang X, Wang S, Lu Y, Gibson MP, Liu Y, Yuan B, Feng JQ, Qin C., Free PMC Article | 12/29/2012 |