| Loci cg06256735 and cg15815843 in the MFAP5 gene regulatory regions are hypomethylated in varicose veins apparently due to active demethylation. | Loci cg06256735 and cg15815843 in the MFAP5 gene regulatory regions are hypomethylated in varicose veins apparently due to active demethylation.
Smetanina MA, Korolenya VA, Sipin FA, Oscorbin IP, Sevostyanova KS, Gavrilov KA, Shevela AI, Filipenko ML., Free PMC Article | 09/17/2024 |
| Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin alphavbeta3/PTK2/AKT Signaling. | Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling.
Chen Z, Zhao H, Meng L, Yu S, Liu Z, Xue J. | 07/31/2023 |
| Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix. | Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix.
Duan Y, Zhang X, Ying H, Xu J, Yang H, Sun K, He L, Li M, Ji Y, Liang T, Bai X., Free PMC Article | 06/21/2023 |
| MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation. | MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
Wu L, Zhou F, Xin W, Li L, Liu L, Yin X, Xu X, Wang Y, Hua Z. | 04/9/2022 |
| Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility. | Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.
Zhao L, Xu L, Hemmerich A, Ferguson NL, Guy CD, McCall SJ, Cardona DM, Westerhoff M, Pai RK, Xiao SY, Liu B, Green CL, Hart J, Zhang X. | 04/3/2021 |
| CAFs-derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling. | CAFs-derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling.
Zhou Z, Cui D, Sun MH, Huang JL, Deng Z, Han BM, Sun XW, Xia SJ, Sun F, Shi F. | 01/23/2021 |
| Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling. | Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling.
Chen Z, Yan X, Li K, Ling Y, Kang H. | 01/16/2021 |
| Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer. | Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer.
Yeung TL, Leung CS, Yip KP, Sheng J, Vien L, Bover LC, Birrer MJ, Wong STC, Mok SC., Free PMC Article | 09/12/2020 |
| this study showed that MFAP5 is a novel myoepithelial cell marker that appears to be upregulated in duct epithelium in duct carcinoma in situ and invasive carcinoma of no special type during tumorogenesis | Immunohistochemical Expression of Microfibrillar-associated Protein 5 (MFAP5) in Invasive Breast Carcinoma of No Special Type.
Dawoud MM, Abouelfadl D, Abdou AG, Elkhouly EAB. | 06/20/2020 |
| Authors showed that MFAP5 promoted ICC cell growth and G1 to S-phase transition. Using RNA-seq expression and ATAC-seq chromatin accessibility profiling of ICC cells with suppressed MFAP5 secretion, we showed that MFAP5 regulated the expression of genes involved in the Notch1 signaling pathway. | MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway.
Li JH, Zhu XX, Li FX, Huang CS, Huang XT, Wang JQ, Gao ZX, Li SJ, Xu QC, Zhao W, Yin XY., Free PMC Article | 06/6/2020 |
| MFAP5 is a useful marker that may help distinguish normal connective tissue from stroma within invasive colonic adenocarcinoma | Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma.
Zhao L, Westerhoff M, Hornick JL, Krausz T, Antic T, Xiao SY, Hart J. | 04/4/2020 |
| Microfibrial-associated glycoprotein 2(MAGP2) negatively modulated by miR-200b-3p, is an oncogene of colorectal cancer associated with patients' prognosis. It may function as a potential biomarker and therapeutic target for colorectal cancer | MAGP2, a Component of Extracellular Matrix, Is Upregulated in Colorectal Cancer and Negatively Modulated by miR-200b-3p.
Feifei W, Hui G, Ruiqiang Z, Qunxiang J, Yu'an X., Free PMC Article | 02/22/2020 |
| Using in vitro assays, we demonstrated that MFAP5 activated OTSCC ( Oral Tongue Squamous Cell Carcinoma) cell growth and migration via activation of MAPK and AKT pathways. Using a tissue microarray of richly annotated primary human OTSCCs, we demonstrated an association of MFAP5 expression with patient survival. | Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.
Principe S, Mejia-Guerrero S, Ignatchenko V, Sinha A, Ignatchenko A, Shi W, Pereira K, Su S, Huang SH, O'Sullivan B, Xu W, Goldstein DP, Weinreb I, Ailles L, Liu FF, Kislinger T. | 06/15/2019 |
| We identified several potential key players contributing to extracellular matrix remodeling in varicose veins. Specifically, our analysis suggests MFAP5 acting as a master regulator, upstream of integrins, of the cellular network affecting the varicose vein condition. | DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease.
Smetanina MA, Kel AE, Sevost'ianova KS, Maiborodin IV, Shevela AI, Zolotukhin IA, Stegmaier P, Filipenko ML. | 05/25/2019 |
| Data show that MAGP-2, component of the extracellular matrix interact with fibrillin and impart unique biological properties that influence microfibril function. Mutations in MAGP-2 have been linked to thoracic aneurysms and metabolic diseases and was shown to be an important biomarker in several human cancers. Also, mice lacking MAGP-2 have defects in multiple organ systems. [review] | Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.
Craft CS, Broekelmann TJ, Mecham RP., Free PMC Article | 05/25/2019 |
| This study identified a critical role played by MFAP5 in the progression of cervical cancer. | MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer.
Li Q, Zhang Y, Jiang Q. | 05/18/2019 |
| MFAP5 was up-regulated in breast cancers compared with that in normal breast tissues, and further increased in breast cancer bone metastasis. Functionally, MFAP5 overexpression accelerated breast cancer cell proliferation and migration, while an opposite effect was observed when MFAP5 was knocked down. | MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer.
Wu Z, Wang T, Fang M, Huang W, Sun Z, Xiao J, Yan W. | 05/5/2018 |
| Study shows that over-expression of MFAP5 and TNNC1 is correlated with cervical lymph node metastasis (CLNM), metastasis relapse-free survival and overall survival. These results propose that MFAP5 and TNNC1 may be potential markers for predicting occult cervical lymphatic metastasis and prognosis of oral tongue carcinoma. | MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer.
Yang X, Wu K, Li S, Hu L, Han J, Zhu D, Tian X, Liu W, Tian Z, Zhong L, Yan M, Zhang C, Zhang Z., Free PMC Article | 02/24/2018 |
| Likely pathogenic variants included a TGFB2 variant in one patient and a SMAD3 variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5, which were identified in a third patient | Clinically relevant variants identified in thoracic aortic aneurysm patients by research exome sequencing.
Schubert JA, Landis BJ, Shikany AR, Hinton RB, Ware SM., Free PMC Article | 01/14/2017 |
| The results answer the question of how MAGP2 controls cell type dependent Notch signaling, but more importantly uncover a new mechanism to understand how extracellular matrices and cellular environments impact Notch signaling. | MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM-integrin-Notch signaling axis.
Deford P, Brown K, Richards RL, King A, Newburn K, Westover K, Albig AR., Free PMC Article | 07/2/2016 |
| Our results demonstrate that factors involving low-grade inflammation modulate MFAP5 expression and that the modified expression of MFAP5 may further regulate adipose tissue inflammation. | MFAP5 is related to obesity-associated adipose tissue and extracellular matrix remodeling and inflammation.
Vaittinen M, Kolehmainen M, Rydén M, Eskelinen M, Wabitsch M, Pihlajamäki J, Uusitupa M, Pulkkinen L. | 02/6/2016 |
| FAK/CREB/TNNC1 has a role in mediating the effect of stromal MFAP5 on ovarian cancer metastatic potential | Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.
Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC., Free PMC Article | 12/19/2015 |
| Alteration of MAGP-2, a component of microfibrils and elastic fibers, appears as an initiating mechanism of inherited Thoracic aortic aneurysm and dissection (TAAD). | MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections.
Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, Abifadel M, Milleron O, Odent S, Dupuis-Girod S, Faivre L, Edouard T, Dulac Y, Busa T, Gouya L, Milewicz DM, Jondeau G, Boileau C., Free PMC Article | 02/28/2015 |
| EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit | Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B., Free PMC Article | 02/28/2015 |
| Decreased MFAP5 gene expression in the endometrium of patients with implantation failure after in vitro ertilization treatment | NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment.
Turkyilmaz E, Guner H, Erdem M, Erdem A, Biri AA, Konac E, Alp E, Onen HI, Menevse S. | 11/17/2012 |