| Serum Spexin Level Is Negatively Associated With Peripheral Neuropathy and Sensory Pain in Type 2 Diabetes. | Serum Spexin Level Is Negatively Associated With Peripheral Neuropathy and Sensory Pain in Type 2 Diabetes.
Liu Y, Wu D, Zheng H, Ni Y, Zhu L, Jiang Y, Dai J, Sun Q, Zhao Y, Zhang Q, Yang Y, Liu R., Free PMC Article | 07/1/2024 |
| Normalization of Spexin Levels in Patients with Obesity Submitted to Bariatric Surgery. | Normalization of Spexin Levels in Patients with Obesity Submitted to Bariatric Surgery.
Bufano A, Iraci Sareri G, Ciuoli C, Cantara S, Marzocchi C, Benenati N, Batzibal MS, Bombardieri A, Caprio S, Sannino I, Voglino C, Tirone A, Vuolo G, Dalmiglio C, Castagna MG. | 02/5/2024 |
| Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferationdagger. | Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation†.
Kurowska P, Dawid M, Oprocha J, Respekta N, Serra L, Estienne A, Pawlicki P, Kotula-Balak M, Guérif F, Dupont J, Rak A., Free PMC Article | 11/20/2023 |
| The role of spexin in energy metabolism. | The role of spexin in energy metabolism.
Sun X, Yu Z, Xu Y, Pu S, Gao X. | 05/23/2023 |
| Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term. | Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term.
Öztürk Önsal FD, Elitok GK, Bülbül A, Uçar A. | 05/14/2022 |
| The effect of umbilical cord blood spexin, free 25(OH) vitamin D3 and adipocytokine levels on intrauterine growth and anthropometric measurements in newborns. | The effect of umbilical cord blood spexin, free 25(OH) vitamin D3 and adipocytokine levels on intrauterine growth and anthropometric measurements in newborns.
Sanli S, Bulbul A, Ucar A. | 02/5/2022 |
| The Association of Serum Circulating Neuropeptide Q and Chemerin Levels with Cardiometabolic Risk Factors among Patients with Metabolic Syndrome. | The Association of Serum Circulating Neuropeptide Q and Chemerin Levels with Cardiometabolic Risk Factors among Patients with Metabolic Syndrome.
Pelczyńska M, Mikulska AA, Czyżewska K, Bogdański P, Grzelak T., Free PMC Article | 01/22/2022 |
| Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus. | Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus.
Pałasz A, Suszka-Świtek A, Kaśkosz A, Plewka D, Bogus K, Filipczyk Ł, Błaszczyk I, Bacopoulou F, Worthington JJ, Piwowarczyk-Nowak A, Tyszkiewicz-Nwafor M, Wiaderkiewicz R. | 07/17/2021 |
| Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus. | Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus.
Yavuzkir S, Ugur K, Deniz R, Ustebay DU, Mirzaoglu M, Yardim M, Sahin İ, Baykus Y, Karagoz ZK, Aydin S. | 04/17/2021 |
| Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors. | Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors.
Behrooz M, Vaghef-Mehrabany E, Ostadrahimi A. | 09/19/2020 |
| Spexin levels were significantly higher in women with gestational diabetes and closely related to HOMA-IR in the third trimester pregnancy. | Serum levels of spexin are increased in the third trimester pregnancy with gestational diabetes mellitus.
Akbas M, Koyuncu FM, Oludag Mete T, Taneli F, Ozdemir H, Yilmaz O. | 04/11/2020 |
| serum SPX levels significantly decreased in obese children and negatively correlated with insulin resistance and pancreatic beta cell function indicators | Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese Children.
Chen T, Wang F, Chu Z, Sun L, Lv H, Zhou W, Shen J, Chen L, Hou M. | 02/29/2020 |
| SPX levels are positively influenced by glucose intolerance in pregnant women with Gestational Diabetes Mellitus (GDM), while they decrease in control women without GDM. | Circulating spexin levels are influenced by the presence or absence of gestational diabetes.
Al-Daghri NM, Sabico S, Al-Hazmi H, Alenad AM, Al-Amro A, Al-Ghamdi A, Hussain SD, Chrousos G, Alokail MS. | 02/22/2020 |
| SPX is a novel regulator of lipid metabolism in murine 3T3-L1 and human adipocytes. | Spexin: A novel regulator of adipogenesis and fat tissue metabolism.
Kolodziejski PA, Pruszynska-Oszmalek E, Micker M, Skrzypski M, Wojciechowicz T, Szwarckopf P, Skieresz-Szewczyk K, Nowak KW, Strowski MZ. | 06/8/2019 |
| Lower circulating levels of SPX in adults are modestly associated with components of metabolic syndrome and are sex-specific. | Spexin Levels Are Associated with Metabolic Syndrome Components.
Al-Daghri NM, Alenad A, Al-Hazmi H, Amer OE, Hussain SD, Alokail MS., Free PMC Article | 01/26/2019 |
| Data suggest that, in response to oral glucose (as in oral glucose tolerance test), adolescent serum spexin levels are not significantly correlated with body composition, fitness, or blood biochemical measurements; these studies were conducted in adolescents with either healthy normal weight, obesity, type 2 diabetes, or obesity plus type 2 diabetes. | Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents.
Hodges SK, Teague AM, Dasari PS, Short KR. | 11/3/2018 |
| Serum levels of both spexin and kisspetin show negative correlation with obesity and insulin resistance in women. | Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women.
Kołodziejski PA, Pruszyńska-Oszmałek E, Korek E, Sassek M, Szczepankiewicz D, Kaczmarek P, Nogowski L, Maćkowiak P, Nowak KW, Krauss H, Strowski MZ. | 09/8/2018 |
| Lower circulating levels of Spexin in obese children compared with their normal-weight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity. | Decreased Circulating Levels of Spexin in Obese Children.
Kumar S, Hossain J, Nader N, Aguirre R, Sriram S, Balagopal PB., Free PMC Article | 07/8/2017 |
| The results suggest that C12orf39, CSTA, and CALCB are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element. | Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.
Maruyama R, Shimizu M, Ishijima T, Nakai Y, Inoue J, Sato R. | 01/28/2017 |
| Circulating spexin levels are low in T2DM patients and negatively related to blood glucose and lipids suggesting that the peptide may play a role in glucose and lipid metabolism in T2DM. | Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes.
Gu L, Ma Y, Gu M, Zhang Y, Yan S, Li N, Wang Y, Ding X, Yin J, Fan N, Peng Y. | 06/28/2016 |
| Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin receptors GALR2/GALR3 (but not GALR1); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2/GALR3. | Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Kim DK, Yun S, Son GH, Hwang JI, Park CR, Kim JI, Kim K, Vaudry H, Seong JY. | 06/21/2014 |
| newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses | Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
Toll L, Khroyan TV, Sonmez K, Ozawa A, Lindberg I, McLaughlin JP, Eans SO, Shahien AA, Kapusta DR., Free PMC Article | 04/14/2012 |
| Taken together, although C12ORF39 is not a secreted small peptide, it can also be secreted to play a role in the biological functions of the placenta. | C12ORF39, a novel secreted protein with a typical amidation processing signal.
Wan B, Wang XR, Zhou YB, Zhang X, Huo K, Han ZG. | 01/27/2010 |