| Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease. | Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
Stavrou MR, So SS, Finch AM, Ballouz S, Smith NJ. | 11/6/2023 |
| Polymorphic variants in Sweet and Umami taste receptor genes and birthweight. | Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Farinella R, Erbi I, Bedini A, Donato S, Gentiluomo M, Angelucci C, Lupetti A, Cuttano A, Moscuzza F, Tuoni C, Rizzato C, Ciantelli M, Campa D., Free PMC Article | 12/11/2021 |
| Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes. | Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.
Esberg A, Haworth S, Hasslöf P, Lif Holgerson P, Johansson I., Free PMC Article | 12/5/2020 |
| Association of taste receptor gene polymorphisms with dental caries. | Association of taste receptor gene polymorphisms with dental caries.
Arid J, Antunes LAA, Koch LFA, Evangelista SS, Vasconcelos KRF, Brancher JA, Gabardo MCL, Milani AJ, Dutra ALT, Antunes LS, Vieira AR, Feltrin-Souza J, KÜchler EC. | 08/22/2020 |
| Using homology modeling, molecular docking and molecular dynamics (MD) simulations, this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3. | Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.
Liu H, Da LT, Liu Y. | 06/20/2020 |
| Studied association of taste 1 receptor member 1 (TAS1R1) and taste 1 receptor member 3 (TAS1R3) single nucleotide polymorphisms (SNPs) with food choices at a buffet meal. and found certain TAS1R1 and TAS1R3 SNPs to be associated with fat and savoury-tasting and protein-rich food choices following a laboratory buffet in humans. | TAS1R1 and TAS1R3 Polymorphisms Relate to Energy and Protein-Rich Food Choices from a Buffet Meal Respectively.
Han P, Keast R, Roura E., Free PMC Article | 02/23/2019 |
| Genetic variants in TAS1R were associated with dietary consumption, which may be associated with gastric cancer risk | Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population.
Choi JH, Lee J, Choi IJ, Kim YW, Ryu KW, Kim J. | 01/13/2018 |
| The study provides human psychophysical evidence that TAS1R1 polymorphisms associate with modest differences in overall taste intensity, which were independent from other well-studied markers of variation in oral sensation. | Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity?
Rawal S, Hayes JE, Wallace MR, Bartoshuk LM, Duffy VB., Free PMC Article | 04/5/2014 |
| A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3. | Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, Ishimaru Y, Misaka T., Free PMC Article | 02/22/2014 |
| Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa. | Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
Meyer D, Voigt A, Widmayer P, Borth H, Huebner S, Breit A, Marschall S, de Angelis MH, Boehm U, Meyerhof W, Gudermann T, Boekhoff I., Free PMC Article | 06/23/2012 |
| amino acid substitutions (A110V and R507Q) in the N-terminal ligand-binding domain of T1R1 severely impair receptor functions in vitro | Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function.
Raliou M, Grauso M, Hoffmann B, Schlegel-Le-Poupon C, Nespoulous C, Débat H, Belloir C, Wiencis A, Sigoillot M, Bano SP, Trotier D, Pernollet JC, Montmayeur JP, Faurion A, Briand L. | 12/24/2011 |
| In our sample of subjects, the frequencies of 2 nsSNPs, C329T in tas1r1 and C2269T in tas1r3, were significantly higher in [glutamate] nontasters than expected, whereas G1114A in tas1r1 was more frequent in tasters. | Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate.
Raliou M, Wiencis A, Pillias AM, Planchais A, Eloit C, Boucher Y, Trotier D, Montmayeur JP, Faurion A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation between common variation in genes encoding sweet taste signaling components and human sucrose perception.
Fushan AA, Simons CT, Slack JP, Drayna D. Association study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.
Chen QY, Alarcon S, Tharp A, Ahmed OM, Estrella NL, Greene TA, Rucker J, Breslin PA. | 08/12/2009 |
| Taken together, these results suggest that Tas1R1-Tas1R3 receptor variants found in human fungiform papillae might contribute to inter-individual differences of sensitivity to L-glutamate. | Tas1R1-Tas1R3 taste receptor variants in human fungiform papillae.
Raliou M, Boucher Y, Wiencis A, Bézirard V, Pernollet JC, Trotier D, Faurion A, Montmayeur JP. | 01/21/2010 |
| human duodenal L cells express sweet taste receptor T1r. | Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM., Free PMC Article | 01/21/2010 |
| findings demonstrate the different functional roles of T1R3 and T1R2 and the presence of multiple ligand binding sites on the sweet taste receptor | Different functional roles of T1R subunits in the heteromeric taste receptors.
Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X., Free PMC Article | 01/21/2010 |
| sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses | An amino-acid taste receptor.
Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS. | 01/21/2010 |
| In vivo taste bud signaling may proceed primarily through hT1R1 and hT1R2. | The G-protein coupling properties of the human sweet and amino acid taste receptors.
Sainz E, Cavenagh MM, LopezJimenez ND, Gutierrez JC, Battey JF, Northup JK, Sullivan SL. | 01/21/2010 |