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    SETD7 SET domain containing 7, histone lysine methyltransferase [ Homo sapiens (human) ]

    Gene ID: 80854, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma.

    SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma.
    Zhang J, Duan B, Li F, Jing X, Li R, Cai S, Cao L, Jiang Q, Zhou J, Zhou J, Qin Y, Wang X, Tong D, Huang C., Free PMC Article

    10/29/2024
    Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells.

    Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells.
    Du Y, Jiang X, Zhang Y, Ying J, Yi Q.

    09/4/2024
    ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.

    ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.
    Yang Y, Xie W, Qiao X, Yang J, Yao D, Zhu D.

    07/26/2024
    Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma.

    Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma.
    Shi Y, Wang Z, Shao Y, Guang Q, Zhang J, Liu B, Wu C, Wang Y, Sui P.

    04/12/2024
    Methyltransferase Set7/9 controls PARP1 expression and regulates cisplatin response of breast cancer cells.

    Methyltransferase Set7/9 controls PARP1 expression and regulates cisplatin response of breast cancer cells.
    Myadelets D, Parfenyev S, Vasileva J, Shuvalov O, Petukhov A, Fedorova O, Barlev N, Daks A.

    01/4/2024
    SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.

    SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.
    Gu R, Kim TD, Song H, Sui Y, Shin S, Oh S, Janknecht R., Free PMC Article

    11/10/2023
    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer.

    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer.
    Chiang CY, Fan S, Zheng H, Guo W, Zheng Z, Sun Y, Zhong C, Zeng J, Li S, Zhang M, Xiao T, Zheng D.

    10/11/2023
    Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascade.

    Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascade.
    Lv J, Wu Q, Li K, Bai K, Yu H, Zhuang J, Sun H, Yang H, Yang X, Lu Q., Free PMC Article

    08/16/2023
    SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1.

    SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1.
    Wang Z, Petricca J, Liu M, Zhang S, Chen S, Li M, Besschetnova A, Patalano S, Venkataramani K, Siegfried KR, Macoska JA, Han D, Gao S, Vedadi M, Arrowsmith CH, He HH, Cai C., Free PMC Article

    08/9/2023
    SET7 methylates the deubiquitinase OTUB1 at Lys [122] to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.

    SET7 methylates the deubiquitinase OTUB1 at Lys (122) to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.
    Deng H, Jia S, Tang J, Rong F, Xu C, Chen X, Wang Z, Zhu C, Sun X, Liao Q, Liu W, Li W, Xiao W, Liu X., Free PMC Article

    05/1/2023
    DDB1 regulates the activation-induced apoptosis of T cells via downregulating the expression of histone methyltransferase SETD7.

    DDB1 regulates the activation-induced apoptosis of T cells via downregulating the expression of histone methyltransferase SETD7.
    Wu R, Wu X, Zou L, Zhou L, Mao Y.

    04/14/2023
    [Research Progress of Role and Mechanism of SETD7 in Tumor Occurrence and Progression].

    [Research Progress of Role and Mechanism of SETD7 in Tumor Occurrence 
and Progression].
    Cao L, Wang M, Xu K., Free PMC Article

    02/22/2023
    Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischaemic injury: a translational study.

    Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischaemic injury: a translational study.
    Ambrosini S, Montecucco F, Kolijn D, Pedicino D, Akhmedov A, Mohammed SA, Herwig M, Gorica E, Szabó PL, Weber L, Russo G, Vinci R, Matter CM, Liuzzo G, Brown PJ, Rossi FMV, Camici GG, Sciarretta S, Beltrami AP, Crea F, Podesser B, Lüscher TF, Kiss A, Ruschitzka F, Hamdani N, Costantino S, Paneni F.

    01/28/2023
    The role of SET domain containing lysine methyltransferase 7 in tumorigenesis and development.

    The role of SET domain containing lysine methyltransferase 7 in tumorigenesis and development.
    Yang S, Wang X, Bai J, Duan B., Free PMC Article

    01/21/2023
    Non-histone Methylation of SET7/9 and its Biological Functions.

    Non-histone Methylation of SET7/9 and its Biological Functions.
    Gao L, Yu W, Song P, Li Q.

    07/2/2022
    Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis.

    Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis.
    Liu Z, Chen B, Chang J, Feng L, Zhao X.

    05/14/2022
    SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation.

    SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation.
    Kwon DH, Kang JY, Joung H, Kim JY, Jeong A, Min HK, Shin S, Lee YG, Kim YK, Seo SB, Kook H., Free PMC Article

    02/19/2022
    lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.

    lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
    Wang H, Ma P, Liu P, Guo D, Liu Z, Zhang Z.

    01/8/2022
    Set7/9 controls proliferation and genotoxic drug resistance of NSCLC cells.

    Set7/9 controls proliferation and genotoxic drug resistance of NSCLC cells.
    Daks A, Mamontova V, Fedorova O, Petukhov A, Shuvalov O, Parfenyev S, Netsvetay S, Venina A, Kizenko A, Imyanitov E, Barlev N.

    11/22/2021
    Methylation of PLK1 by SET7/9 ensures accurate kinetochore-microtubule dynamics.

    Methylation of PLK1 by SET7/9 ensures accurate kinetochore-microtubule dynamics.
    Yu R, Wu H, Ismail H, Du S, Cao J, Wang J, Ward T, Yang F, Gui P, Ali M, Chu L, Mo F, Wang Q, Chu Y, Zang J, Zhao Y, Ye M, Fang G, Chen PR, Dou Z, Gao X, Wang W, Liu X, Yao X., Free PMC Article

    08/14/2021
    SET7/9 promotes H3K4me3 at lncRNA DRAIC promoter to modulate growth and metastasis of glioma.

    SET7/9 promotes H3K4me3 at lncRNA DRAIC promoter to modulate growth and metastasis of glioma.
    Li C, Feng SY, Chen L.

    07/3/2021
    The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by beta-Glucan.

    The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan.
    Keating ST, Groh L, van der Heijden CDCC, Rodriguez H, Dos Santos JC, Fanucchi S, Okabe J, Kaipananickal H, van Puffelen JH, Helder L, Noz MP, Matzaraki V, Li Y, de Bree LCJ, Koeken VACM, Moorlag SJCFM, Mourits VP, Domínguez-Andrés J, Oosting M, Bulthuis EP, Koopman WJH, Mhlanga M, El-Osta A, Joosten LAB, Netea MG, Riksen NP., Free PMC Article

    05/15/2021
    METTL3/YTHDF2 m(6) A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.

    METTL3/YTHDF2 m(6) A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.
    Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, He L, Xu X, Liu B, Wang X, Zheng X, Xie L., Free PMC Article

    05/1/2021
    Downregulation of SETD7 promotes migration and invasion of lung cancer cells via JAK2/STAT3 pathway.

    Downregulation of SETD7 promotes migration and invasion of lung cancer cells via JAK2/STAT3 pathway.
    Cao L, Ren Y, Guo X, Wang L, Zhang Q, Li X, Wu X, Meng Z, Xu K.

    02/6/2021
    KMT Set7/9 is a new regulator of Sam68 STAR-protein.

    KMT Set7/9 is a new regulator of Sam68 STAR-protein.
    Vasileva E, Shuvalov O, Petukhov A, Fedorova O, Daks A, Nader R, Barlev N.

    01/2/2021
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