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    ACTN4 actinin alpha 4 [ Homo sapiens (human) ]

    Gene ID: 81, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of ACTN4 Gene Mutation with Primary Nephrotic Syndrome in Children in Guangxi Autonomous Region, China.

    Association of ACTN4 Gene Mutation with Primary Nephrotic Syndrome in Children in Guangxi Autonomous Region, China.
    Cao S, Wang D, Liu L, Yao J, Wang L, Liao Y, Zhang J, Zhao J, Huang Y, Hao Z.

    08/15/2024
    Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors.

    Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors.
    Alsouri S, Ambrose A, Mougios N, Paglilla N, Mayr F, Choi K, Loeber J, Chapuy B, Haeupl B, Opazo F, Oellerich T, Gold M, Engelke M.

    03/19/2024
    Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte.

    Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte.
    Hsu MF, Ito Y, Singh JP, Hsu SF, Wells A, Jen KY, Meng TC, Haj FG.,

    11/20/2023
    PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.

    PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
    Cheng M, Cao H, Yao P, Guan J, Wu P, Ji H, Jiang S, Yuan Y, Fu L, Zheng Q, Li Q., Free PMC Article

    08/30/2023
    Analysis of the association of NPHS2 and ACTN4 genes polymorphism with nephrotic syndrome in Egyptian children.

    Analysis of the association of NPHS2 and ACTN4 genes polymorphism with nephrotic syndrome in Egyptian children.
    Al-Azzawy MF, Al-Haggar M, ElSaid AM, El-Khawaga OY., Free PMC Article

    05/18/2023
    Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension.

    Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension.
    Hafeez N, Kirillova A, Yue Y, Rao RJ, Kelly NJ, El Khoury W, Al Aaraj Y, Tai YY, Handen A, Tang Y, Jiang D, Wu T, Zhang Y, McNamara D, Kudryashova TV, Goncharova EA, Goncharov D, Bertero T, Nouraie M, Li G, Sun W, Chan SY., Free PMC Article

    04/10/2023
    Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells.

    Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells.
    Kriger D, Novitskaya K, Vasileva G, Lomert E, Aksenov ND, Barlev NA, Tentler D., Free PMC Article

    12/17/2022
    Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR-876-3p.

    Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR-876-3p.
    Liang X, Liu X, Song Z, Zhu J, Zhang J.

    11/5/2022
    C-Mannosylated tryptophan-containing WSPW peptide binds to actinin-4 and alters E-cadherin subcellular localization in lung epithelial-like A549 cells.

    C-Mannosylated tryptophan-containing WSPW peptide binds to actinin-4 and alters E-cadherin subcellular localization in lung epithelial-like A549 cells.
    Ikezaki M, Nishitsuji K, Matsumura K, Manabe S, Shibukawa Y, Wada Y, Ito Y, Ihara Y.

    02/5/2022
    The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma.

    The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma.
    Xie P, Chen Y, Zhang H, Zhou G, Chao Q, Wang J, Liu Y, Fang J, Xie J, Zhen J, Wang Z, Hao L, Huang D., Free PMC Article

    01/15/2022
    Distinct forms of the actin cross-linking protein alpha-actinin support macropinosome internalization and trafficking.

    Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking.
    Burton KM, Johnson KM, Krueger EW, Razidlo GL, McNiven MA., Free PMC Article

    12/25/2021
    The association of NPHS1 and ACNT4 gene polymorphisms with pre-eclampsia.

    The association of NPHS1 and ACNT4 gene polymorphisms with pre-eclampsia.
    Khaliq OP, Konoshita T, Moodley J, Naicker T.

    12/18/2021
    [Molecular mechanism of miR-369-3p regulating hepatocellular carcinoma cell proliferation and apoptosis by targeting ACTN4].

    [Molecular mechanism of miR-369-3p regulating hepatocellular carcinoma cell proliferation and apoptosis by targeting ACTN4].
    Zhao HF, Lou M, Bi MP, Yang XW, Hu PY, Liu JL.

    11/27/2021
    Alpha-actinin-4 is essential for maintaining normal trophoblast proliferation and differentiation during early pregnancy.

    Alpha-actinin-4 is essential for maintaining normal trophoblast proliferation and differentiation during early pregnancy.
    Peng W, Liu Y, Qi H, Li Q., Free PMC Article

    11/13/2021
    TRIP13 exerts a cancer-promoting role in cervical cancer by enhancing Wnt/beta-catenin signaling via ACTN4.

    TRIP13 exerts a cancer-promoting role in cervical cancer by enhancing Wnt/β-catenin signaling via ACTN4.
    Liu X, Shen X, Zhang J.

    09/4/2021
    Serum Actinin-4 Levels as a Potential Diagnostic and Prognostic Marker in Cervical Cancer.

    Serum Actinin-4 Levels as a Potential Diagnostic and Prognostic Marker in Cervical Cancer.
    Ma X, Xue H, Zhong J, Feng B, Zuo Y., Free PMC Article

    07/3/2021
    Radixin Relocalization and Nonmuscle alpha-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy.

    Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy.
    Cetinkaya A, Berge B, Sen-Hild B, Troidl K, Gajawada P, Kubin N, Valeske K, Schranz D, Akintürk H, Schönburg M, Kubin T, Choi YH, Richter M., Free PMC Article

    06/12/2021
    ACTN4 Promotes the Proliferation, Migration, Metastasis of Osteosarcoma and Enhances its Invasive Ability through the NF-kappaB Pathway.

    ACTN4 Promotes the Proliferation, Migration, Metastasis of Osteosarcoma and Enhances its Invasive Ability through the NF-κB Pathway.
    Huang Q, Li X, Huang Z, Yu F, Wang X, Wang S, He Z, Lin J., Free PMC Article

    04/3/2021
    Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma.

    Prognostic impact of ACTN4 gene copy number alteration in hormone receptor-positive, HER2-negative, node-negative invasive breast carcinoma.
    Sugano T, Yoshida M, Masuda M, Ono M, Tamura K, Kinoshita T, Tsuda H, Honda K, Gemma A, Yamada T., Free PMC Article

    03/20/2021
    Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.

    Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.
    Feng D, Kumar M, Muntel J, Gurley SB, Birrane G, Stillman IE, Ding L, Wang M, Ahmed S, Schlondorff J, Alper SL, Ferrante T, Marquez SL, Ng CF, Novak R, Ingber DE, Steen H, Pollak MR., Free PMC Article

    02/27/2021
    alpha-Actinin-4 regulates cancer stem cell properties and chemoresistance in cervical cancer.

    α-Actinin-4 regulates cancer stem cell properties and chemoresistance in cervical cancer.
    Jung J, Kim S, An HT, Ko J.

    02/6/2021
    Dynamin 2 interacts with alpha-actinin 4 to drive tumor cell invasion.

    Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion.
    Burton KM, Cao H, Chen J, Qiang L, Krueger EW, Johnson KM, Bamlet WR, Zhang L, McNiven MA, Razidlo GL., Free PMC Article

    01/23/2021
    Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations.

    Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations.
    Shao H, Wingert B, Weins A, Pollak MR, Camacho C, Wells A., Free PMC Article

    11/21/2020
    The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer.

    The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer.
    Ishizuya Y, Uemura M, Narumi R, Tomiyama E, Koh Y, Matsushita M, Nakano K, Hayashi Y, Wang C, Kato T, Hatano K, Kawashima A, Ujike T, Fujita K, Imamura R, Adachi J, Tomonaga T, Nonomura N.

    09/12/2020
    ACTN4 was dysregulated in placentas from early onset preeclampsia. ACTN4 knockdown inhibited trophoblast cell proliferation by reducing AKT membrane translocation in vitro.

    Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.
    Peng W, Tong C, Li L, Huang C, Ran Y, Chen X, Bai Y, Liu Y, Zhao J, Tan B, Luo X, Wang H, Wen L, Zhang C, Zhang H, Ding Y, Qi H, Baker PN.

    05/23/2020
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