ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent Manner and Regulates Its Protein Stability in the Cytoplasm. | ANP32e Binds Histone H2A.Z in a Cell Cycle-Dependent Manner and Regulates Its Protein Stability in the Cytoplasm. Dijkwel Y, Hart-Smith G, Kurscheid S, Tremethick DJ., Free PMC Article | 03/19/2024 |
An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization. | An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization. Sheppard CM, Goldhill DH, Swann OC, Staller E, Penn R, Platt OK, Sukhova K, Baillon L, Frise R, Peacock TP, Fodor E, Barclay WS., Free PMC Article | 11/2/2023 |
ANP32E contributes to gastric cancer progression via NUF2 upregulation. | ANP32E contributes to gastric cancer progression via NUF2 upregulation. Zhu X, Zou Y, Wu T, Ni J, Tan Q, Wang Q, Zhang M., Free PMC Article | 07/23/2022 |
Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation. | Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation. Ruff GL, Murphy KE, Smith ZR, Vertino PM, Murphy PJ., Free PMC Article | 03/5/2022 |
Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma. | Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma. Wang L, Li J, Li Y, Pang LB. | 05/29/2021 |
Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating beta-catenin. | Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating β-catenin. Zhang J, Lan Z, Qiu G, Ren H, Zhao Y, Gu Z, Li Z, Feng L, He J, Wang C., Free PMC Article | 05/15/2021 |
Findings suggest that ANP32E promotes THCA cell proliferation and migration via potentiating AKT/mTOR/HK2-mediated glycolysis. | Up-regulated ANP32E promotes the thyroid carcinoma cell proliferation and migration via activating AKT/mTOR/HK2-mediated glycolysis. Huang J, Gao W, Liu H, Yin G, Duan H, Huang Z, Zhang Y. | 07/25/2020 |
A systems biology approach allowed us to identify a comprehensive mechanism of action of steroid-refractoriness, highlighting the key role of steroid-induced transcription and the potential implication of ANP32E in this phenomenon. | ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach. Lorén V, Garcia-Jaraquemada A, Naves JE, Carmona X, Mañosa M, Aransay AM, Lavin JL, Sánchez I, Cabré E, Manyé J, Domènech E. | 08/24/2019 |
ANP32E is an efficient prognostic marker, and it promotes the G1/S transition and induces tumorigenesis of Triple-negative breast cancer cells by transcriptionally inducing E2F1. | ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1. Xiong Z, Ye L, Zhenyu H, Li F, Xiong Y, Lin C, Wu X, Deng G, Shi W, Song L, Yuan Z, Wang X., Free PMC Article | 05/18/2019 |
Study identified ANP32E as one of the miR-141 targets, and demonstrated its involvement in the regulation of cell proliferation, migration, and invasion of breast cancer cells. | Downregulation of miRNA-141 in breast cancer cells is associated with cell migration and invasion: involvement of ANP32E targeting. Li P, Xu T, Zhou X, Liao L, Pang G, Luo W, Han L, Zhang J, Luo X, Xie X, Zhu K., Free PMC Article | 11/11/2017 |
Dynamic modulation of H2A.Z exchange and removal by Anp32e reveals the importance of the nucleosome surface and nucleosome dynamics in processing the damaged chromatin template during DSB repair. | Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair. Gursoy-Yuzugullu O, Ayrapetov MK, Price BD., Free PMC Article | 10/24/2015 |
Anp32e may help to resolve the non-nucleosomal H2A.Z aggregates and also facilitate the removal of H2A.Z at the +1 nucleosomes, and the latter may help RNA polymerase II to pass the first nucleosomal barrier. | Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z. Mao Z, Pan L, Wang W, Sun J, Shan S, Dong Q, Liang X, Dai L, Ding X, Chen S, Zhang Z, Zhu B, Zhou Z., Free PMC Article | 05/30/2015 |
1.48 A resolution crystal structure of the complex formed between the ANP32E-ZID and the H2A.Z/H2B dimer and biochemical data support an underlying molecular mechanism for H2A.Z/H2B eviction from the nucleosome and its stabilization by ANP32E | ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A. | 02/22/2014 |
The gene was cloned and identified during large-scale sequencing analysis of a human fetal brain cDNA library. | Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain. Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y. | 01/21/2010 |