| Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats. | Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats.
Mead AJ, Ahluwalia K, Ebright B, Zhang Z, Dave P, Li Z, Zhou E, Naik AA, Ngu R, Chester C, Lu A, Asante I, Pollalis D, Martinez JC, Humayun M, Louie S., Free PMC Article | 06/21/2024 |
| Photothermal lipolysis accelerates ECM production via macrophage-derived ALOX15-mediated p38 MAPK activation in fibroblasts. | Photothermal lipolysis accelerates ECM production via macrophage-derived ALOX15-mediated p38 MAPK activation in fibroblasts.
Wu S, Wang C, Yao M, Han D, Li Q. | 04/6/2023 |
| Alox15 processing of DHA contributes to production of resolvin D1 and LTP at hippocampo-prefrontal cortical synapses and associated spatial working memory performance. | Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory.
Shalini SM, Ho CF, Ng YK, Tong JX, Ong ES, Herr DR, Dawe GS, Ong WY., Free PMC Article | 12/22/2018 |
| Consistent with the decreases in the 15-LOX metabolites, expression levels of the genes that encode the 15-LOXs, Alox15 and Alox15b, were largely reduced in Olmsted syndrome model rats. | Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Igarashi Y, Kihara A. | 07/15/2017 |
| Hypoxia increase the production of ROS through the 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid pathway. | Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
Li Q, Mao M, Qiu Y, Liu G, Sheng T, Yu X, Wang S, Zhu D., Free PMC Article | 07/30/2016 |
| the increased expression of 12/15-LOX, predominantly in neurons, and elevated production of 12(S)-HETE and 15(S)-HETE in ischemic brain. | 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain.
Sun L, Xu YW, Han J, Liang H, Wang N, Cheng Y., Free PMC Article | 11/21/2015 |
| Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas. | Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
Coffey R, Nam H, Knutson MD., Free PMC Article | 11/8/2014 |
| suggest that chronic hypoxia promotes monocyte infiltration into the vasculature and adhesion molecules upregulation in pulmonary arterial endothelium cells via a positive interaction between 15-LO/15-HETE and nuclear factor-kappaB | 15-Lipoxygenase promotes chronic hypoxia-induced pulmonary artery inflammation via positive interaction with nuclear factor-κB.
Li J, Rao J, Liu Y, Cao Y, Zhang Y, Zhang Q, Zhu D. | 06/15/2013 |
| Reciprocal regulation of HIF-1alpha and 15-Lipoxygenase/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia. | Reciprocal regulation of HIF-1α and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
Yao L, Nie X, Shi S, Song S, Hao X, Li S, Zhu D. | 04/20/2013 |
| Results support the pro-apoptotic role of 15-lipoxygenase-1 and suggest that 15-lipoxygenase-1 could be a potential new target gene for the therapy of malignant glioma. | 15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma.
Viita H, Pacholska A, Ahmad F, Tietäväinen J, Naarala J, Hyvärinen A, Wirth T, Ylä-Herttuala S. | 06/23/2012 |
| 15-Lox1-15(S)-HETE axis activates EGFR via redox-sensitive manner, which in turn mediates Src-Jak2-STAT3-dependent MCP-1 expression leading to vascular wall remodeling | 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling.
Singh NK, Wang D, Kundumani-Sridharan V, Van Quyen D, Niu J, Rao GN., Free PMC Article | 09/3/2011 |
| both isoenzymes of 15-LOXs are upregulated after hypoxia | Expression of 15-lipoxygenases in pulmonary arteries after hypoxia.
Liu Y, Tang X, Lu C, Han W, Guo S, Zhu D. | 01/25/2010 |
| These results indicate possibility of 12-LOX involvement in ceramide-mediated generation of ROS and cellular oxidative stress. | Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.
Prasad VV, Nithipatikom K, Harder DR. | 01/21/2010 |
| Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells. | Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells.
Reddy MA, Sahar S, Villeneuve LM, Lanting L, Natarajan R., Free PMC Article | 01/21/2010 |
| Induction of Alox15 mRNA expression may be the primary event mediating altered intestinal lipid metabolism in iron deficiency. | Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators.
Collins JF, Hu Z, Ranganathan PN, Feng D, Garrick LM, Garrick MD, Browne RW. | 01/21/2010 |
| These findings suggested that activation of 12-LOX, but not NADPH oxidase, following to zinc release might play an important role in ROS generation and decrease of viability in GD/R-treated neurons. | Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons.
Nagasawa K, Kakuda T, Higashi Y, Fujimoto S. | 01/21/2010 |
| We conclude that 12-LO and its product, 12(S)-HETE, are important intermediates in hypoxia-induced pulmonary artery smooth muscle cell proliferation and may participate in hypoxia-induced pulmonary hypertension | Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Preston IR, Hill NS, Warburton RR, Fanburg BL. | 01/21/2010 |
| These results show that the 12-LOX pathway is a regulator of cell survival and apoptosis, by affecting the expression and localization of the alphavbeta5 integrin and actin microfilaments in Walker 256 cells. | Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression.
Pidgeon GP, Tang K, Rice RL, Zacharek A, Li L, Taylor JD, Honn KV. | 01/21/2010 |
| Results indicate that C-terminus of p47(phox) is important for its interaction to rat 12-lipoxygenase. | C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase.
Tanabe M, Kamitani H, Watanabe T, Rådmark O. | 01/21/2010 |
| Data suggest that naturally occurring 12S-lipoxygenases exhibit an intrinsic hepoxilin A(3) synthase activity that is minimal in lipoxygenase isoforms with different positional specificity. | The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity.
Nigam S, Patabhiraman S, Ciccoli R, Ishdorj G, Schwarz K, Petrucev B, Kühn H, Haeggström JZ. | 01/21/2010 |
| results indicate for the first time that 12/15-LO and COX-2 pathways can cross-talk and activate each other in mesangial cells; these novel interactions may amplify their effects on the progression of diabetic nephropathy | Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.
Xu ZG, Li SL, Lanting L, Kim YS, Shanmugam N, Reddy MA, Natarajan R. | 01/21/2010 |
| 12/15-LOX-dependent up-regulation of sPLA2-IIA expression may result from the interplay between accelerated MIP-2 signaling, AP-1 activation, and attenuated transforming growth factor-beta and platelet-derived growth factor signaling | Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
Kuwata H, Nonaka T, Murakami M, Kudo I. | 01/21/2010 |
| 12/15-LO activation has roles in macrophage and vascular smooth muscle cell oxidant stress and inflammation | Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.
Li SL, Dwarakanath RS, Cai Q, Lanting L, Natarajan R. | 01/21/2010 |
| A leukocyte-type 12S-lipoxygenase isolated from rat insulinoma RINm5F cells exhibits an intrinsic hepoxilin A3 synthase (HXA3) activity. | Hepoxilin A3 synthase.
Nigam S, Zafiriou MP. | 01/21/2010 |
| arachidonic acid metabolism through LOX activity, is a major source of extracellular O(2)(*-) release in skeletal muscle. | Lipoxygenase-dependent superoxide release in skeletal muscle.
Zuo L, Christofi FL, Wright VP, Bao S, Clanton TL. | 01/21/2010 |