| KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE. | KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE.
Sun F, Zhao T., Free PMC Article | 10/17/2024 |
| Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma. | Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.
Ren J, Yao X, Yang M, Cheng S, Wu D, Xu K, Li R, Zhang H, Zhang D., Free PMC Article | 05/1/2024 |
| KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway. | KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B., Free PMC Article | 02/29/2024 |
| Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis. | Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.
Cai F, Li J, Zhang J, Huang S. | 08/13/2022 |
| Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment. | Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
Risteski P, Božan D, Jagrić M, Bosilj A, Pavin N, Tolić IM., Free PMC Article | 08/13/2022 |
| Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus. | Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Cho YB, Hong S, Kang KW, Kang JH, Lee SM, Seo YJ., Free PMC Article | 09/11/2021 |
| KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer. | KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
Qian LX, Cao X, Du MY, Ma CX, Zhu HM, Peng Y, Hu XY, He X, Yin L. | 08/14/2021 |
| Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line. | Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line.
Smialek MJ, Kuczynska B, Ilaslan E, Janecki DM, Sajek MP, Kusz-Zamelczyk K, Jaruzelska J. | 08/7/2021 |
| Chromosomally unstable tumor cells specifically require KIF18A for proliferation. | Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Marquis C, Fonseca CL, Queen KA, Wood L, Vandal SE, Malaby HLH, Clayton JE, Stumpff J., Free PMC Article | 03/6/2021 |
| this study showed that KIF18A is overexpressed in patients with LUAD, further confirming that a high KIF18A expression level is correlated with higher pathologic tumor status stage, poorer tumor differentiation, lymph node metastasis, and tumor stage. | High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Li X, Liu M, Zhang Z, Zhang L, Liang X, Sun L, Zhong D., Free PMC Article | 07/4/2020 |
| phylogenetic analysis revealed that the KIF18A gene family is remarkably conserved across vertebrates. | Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
Kim S, Cho YB, Song CU, Eyun SI, Seo YJ. | 06/6/2020 |
| The involvement of KIF18A in the progression and metastasis of lung adenocarcinoma.KIF18A is highly expressed in lung adenocarcinoma tissues. | Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
Chen FT, Zhong FK., Free PMC Article | 05/2/2020 |
| High KIF18A expression is associated with lung adenocarcinoma. | Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma.
Zhong Y, Jiang L, Lin H, Li X, Long X, Zhou Y, Li B, Li Z. | 04/18/2020 |
| These results support a model in which KIF18A's neck linker length permits efficient navigation of obstacles to reach K-fiber ends during mitosis. | KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle.
Malaby HL, Lessard DV, Berger CL, Stumpff J., Free PMC Article | 02/29/2020 |
| The expression of the Kif18A protein by immunohistochemistry was higher in nonsmall cell lung cancer tissues than in normal tissues, and was associated with tumor differentiation, lymph node metastasis, and TNM staging. | Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Guo W, Zeng H, Zheng J, He Y, Zhuang X, Cai J, Huang H, Huang H, Xu M., Free PMC Article | 02/1/2020 |
| High KIF18A expression in prostate cancer patients predicts a poor prognosis. | Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Zhang H, Shen T, Zhang Z, Li Y, Pan Z., Free PMC Article | 01/25/2020 |
| These findings shed new light on the role of Kif18A in chromosome segregation and demonstrate that the spindle assembly checkpoint can be activated at kinetochores that are occupied by fully functional k-Mts that lack tension. | Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.
Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA. | 10/19/2019 |
| KIF18A expression is a predictive biomarker of drug resistance to endocrine therapy in breast cancer. | Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+ breast cancer.
Alfarsi LH, Elansari R, Toss MS, Diez-Rodriguez M, Nolan CC, Ellis IO, Rakha EA, Green AR. | 06/8/2019 |
| High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma. | The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
Luo W, Liao M, Liao Y, Chen X, Huang C, Fan J, Liao W., Free PMC Article | 09/1/2018 |
| Low post translational modifications of KIF18A protein is associated with neoplasms. | Exclusive destruction of mitotic spindles in human cancer cells.
Visochek L, Castiel A, Mittelman L, Elkin M, Atias D, Golan T, Izraeli S, Peretz T, Cohen-Armon M., Free PMC Article | 10/14/2017 |
| KIF18a role in microtubule assembly | Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins.
Wordeman L, Decarreau J, Vicente JJ, Wagenbach M., Free PMC Article | 01/28/2017 |
| Cdk1-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 induces metaphase plate thinning by directly dephosphorylating Kif18A. | Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A.
Häfner J, Mayr MI, Möckel MM, Mayer TU. | 04/30/2016 |
| Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 from kinetochores after anaphase onset. | Sumoylation of Kif18A plays a role in regulating mitotic progression.
Yang F, Chen Y, Dai W., Free PMC Article | 02/6/2016 |
| data support a model in which microtubule-attenuating kinesins are molecularly "tuned" to control the dynamics of specific subsets of spindle microtubules | A unique kinesin-8 surface loop provides specificity for chromosome alignment.
Kim H, Fonseca C, Stumpff J., Free PMC Article | 10/3/2015 |
| a biomarker for hepatocellular carcinoma diagnosis and an independent predictor of overall survival | High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
Liao W, Huang G, Liao Y, Yang J, Chen Q, Xiao S, Jin J, He S, Wang C., Free PMC Article | 08/1/2015 |