| Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch. | Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
Gould GW, Brodsky FM, Bryant NJ. | 06/26/2021 |
| These analyses suggest that ancestral human dietary change influenced selection of allotypes that affect CHC22's role in metabolism and have potential to differentially influence the human insulin response. | Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.
Fumagalli M, Camus SM, Diekmann Y, Burke A, Camus MD, Norman PJ, Joseph A, Abi-Rached L, Benazzo A, Rasteiro R, Mathieson I, Topf M, Parham P, Thomas MG, Brodsky FM., Free PMC Article | 02/22/2020 |
| Provide biochemical evidence for separate regulation and distinct functional niches for CHC17 and CHC22 in HeLa cells. Furthermore, the greater stability of the CHC22 coat relative to the CHC17 coat may be relevant to its excessive accumulation with GLUT4 during insulin resistance. | CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.
Dannhauser PN, Camus SM, Sakamoto K, Sadacca LA, Torres JA, Camus MD, Briant K, Vassilopoulos S, Rothnie A, Smith CJ, Brodsky FM., Free PMC Article | 12/22/2018 |
| Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. Study suggests This suggests that a reduction in CHC22 expression in sensory neural precursors may license a step in neuron precursor neurodevelopment; and that this step is mediated through control of a novel neuropeptide processing pathway. | Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development.
Nahorski MS, Borner GHH, Shaikh SS, Davies AK, Al-Gazali L, Antrobus R, Woods CG., Free PMC Article | 12/22/2018 |
| CLTCL1 is significantly upregulated in the developing human brain | A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.
Nahorski MS, Al-Gazali L, Hertecant J, Owen DJ, Borner GH, Chen YC, Benn CL, Carvalho OP, Shaikh SS, Phelan A, Robinson MS, Royle SJ, Woods CG., Free PMC Article | 10/17/2015 |
| Depletion of clathrin heavy chain (CHC)17, but not the CHC22 clathrin isoform, by ribonucleic acid interference (RNAi) induces centrosome amplification and multipolar spindles. | Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR Jr, Doxsey SJ, Brodsky FM., Free PMC Article | 11/17/2012 |
| A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. | 04/26/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| CHC22 was required for retrograde trafficking of certain cargo molecules from endosomes to the trans-Golgi network. | The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.
Esk C, Chen CY, Johannes L, Brodsky FM., Free PMC Article | 02/8/2010 |
| role for CHC22 in formation of insulin-responsive GLUT4 compartments in muscle & adipocytes; CHC22 associated with expanded GLUT4 compartments in muscle in type 2 diabetes | A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM., Free PMC Article | 01/21/2010 |
| Clathrin isoform CHC22 binds to sorting nexin 5 through a coiled-coil domain. | Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.
Towler MC, Gleeson PA, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, Ordahl C, Parton RG, Brodsky FM., Free PMC Article | 01/21/2010 |