| miR-34b-3p protects against acute kidney injury in sepsis mice via targeting ubiquitin-like protein 4A. | miR-34b-3p protects against acute kidney injury in sepsis mice via targeting ubiquitin-like protein 4A.
He SY, Wang G, Pei YH, Zhu HP. | 08/7/2021 |
| a novel positive feedback regulation of UBL4A in innate immune response combating virus invasion by enhancing the K63-linked ubiquitination of TRAF6. | UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6.
Peng SJ, Yao RR, Yu SS, Chen HY, Pang X, Zhang Y, Zhang J. | 05/23/2020 |
| UBL4A is a novel autophagy inhibitor and tumor suppressor in PDAC. Mechanistically, UBL4A is involved in late stage autophagy, particularly in lysosomal dysfunction, causing impaired degradation of autophagosomes. | UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.
Chen H, Li L, Hu J, Zhao Z, Ji L, Cheng C, Zhang G, Zhang T, Li Y, Chen H, Pan S, Sun B., Free PMC Article | 12/21/2019 |
| The single point mutation of an aspartic acid to alanine (D122A) in the Ubl4A C-terminus abolishes its ability to bind the Arp2/3 complex. This mutation also destabilizes Ubl4A proteins susceptible to protease degradation. Importantly, ectopic expression of wild-type Ubl4A can induce cell death in colon cancer cells, but such pro-death activity is diminished in the D122A mutant. | The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.
Yao Q, Zhang H, Zhao Y, Ye Z, Lee YJ, Xiang J., Free PMC Article | 01/19/2019 |
| The authors identify USP13 as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6. | USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y., Free PMC Article | 02/13/2016 |
| Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT). | Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.
Darby JF, Krysztofinska EM, Simpson PJ, Simon AC, Leznicki P, Sriskandarajah N, Bishop DS, Hale LR, Alfano C, Conte MR, MartÃnez-Lumbreras S, Thapaliya A, High S, Isaacson RL., Free PMC Article | 07/25/2015 |
| Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex. | Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Mock JY, Chartron JW, Zaslaver M, Xu Y, Ye Y, Clemons WM Jr., Free PMC Article | 04/25/2015 |
| Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents. | Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.
Krenciute G, Liu S, Yucer N, Shi Y, Ortiz P, Liu Q, Kim BJ, Odejimi AO, Leng M, Qin J, Wang Y., Free PMC Article | 09/28/2013 |
| Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD). | A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.
Xu Y, Liu Y, Lee JG, Ye Y., Free PMC Article | 09/7/2013 |
| SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. | SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
Xu Y, Cai M, Yang Y, Huang L, Ye Y., Free PMC Article | 06/8/2013 |
| Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface. | Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
Chartron JW, VanderVelde DG, Clemons WM Jr., Free PMC Article | 06/8/2013 |