| Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis. | Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis.
Zhao L, Chen Y, Li H, Ding X, Li J., Free PMC Article | 08/7/2024 |
| Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights. | Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.
Wang CY, Li MY, Li SY, Wei XG, Dong NX, Liu ST, Yuan ZW, Li B, Pierro A, Tang XB, Bai YZ., Free PMC Article | 07/23/2024 |
| RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats. | RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats.
Ni H, Kan X, Rui Q, Zhang Y, Zhai W, Zhang B, Yu Z., Free PMC Article | 03/29/2024 |
| Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis. | Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis.
Sun C, Peng S, Lv Z, Guo T, Zhang L. | 11/3/2023 |
| Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances. | Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances.
do Canto AM, Vieira AS, H B Matos A, Carvalho BS, Henning B, Norwood BA, Bauer S, Rosenow F, Gilioli R, Cendes F, Lopes-Cendes I., Free PMC Article | 12/5/2020 |
| Receptor for activated C kinase 1 mediates the chronic constriction injury-induced neuropathic pain in the rats' peripheral and central nervous system. | Receptor for activated C kinase 1 mediates the chronic constriction injury-induced neuropathic pain in the rats' peripheral and central nervous system.
Lu R, Fan B, Yin D, Li Y, Wang B, Zhu S, Chen Y, Xu Z. | 09/26/2020 |
| the upregulation of RACK1 following brain contusion exerted neuroprotective effects against secondary brain injury | RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats.
Ni H, Rui Q, Xu Y, Zhu J, Gao F, Dang B, Li D, Gao R, Chen G. | 01/12/2019 |
| There were significant differences in inflammation and apoptosis, including the expression of RACK1 and TLR4, after myocardial IRI between the propofol and isoflurane groups | Receptor for activated C kinase 1 in rats with ischemia-reperfusion injury: intravenous versus inhalation anaesthetic agents.
Seo EH, Song GY, Namgung JH, Oh CS, Lee SH, Kim SH., Free PMC Article | 08/25/2018 |
| The scaffolding protein RACK1 is associated with mineralocorticoid receptor (MR) under basal and agonist-stimulated conditions and facilitates agonist-stimulated MR actions through PKC-beta. These findings indicate that RACK1 is a newly described coactivator of MR. | Interaction of the Mineralocorticoid Receptor With RACK1 and Its Role in Aldosterone Signaling.
Kuppusamy M, Gomez-Sanchez EP, Beloate LN, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez CE., Free PMC Article | 09/30/2017 |
| Endoplasmic reticulum stress preconditioning protects against hepatic ischemia/reperfusion injury, which is orchestrated by IRE1-RACK1 axis through the activation of BCL2. | IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver.
Liu D, Liu X, Zhou T, Yao W, Zhao J, Zheng Z, Jiang W, Wang F, Aikhionbare FO, Hill DL, Emmett N, Guo Z, Wang D, Yao X, Chen Y., Free PMC Article | 09/30/2017 |
| RACK1 regulates angiotensin II induced contractions of preglomerular vascular smooth muscle in spontaneously hypertensive rats. | RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells.
Zhu X, Jackson EK., Free PMC Article | 07/15/2017 |
| RACK1 promotes adhesion-mediated activation of ERK2 that in turn inhibits p190A-RhoGAP signaling by reducing the peripheral localization of p190A-RhoGAP. | Symmetry breaking in spreading RAT2 fibroblasts requires the MAPK/ERK pathway scaffold RACK1 that integrates FAK, p190A-RhoGAP and ERK2 signaling.
Klímová Z, Bráborec V, Maninová M, Čáslavský J, Weber MJ, Vomastek T. | 06/3/2017 |
| RACK1 might suppress cardiomyocyte apoptosis aftermyocardial ischemia/reperfusion, providing a novel molecular target for the therapy of ischemia heart disease. | Downregulation of RACK1 is associated with cardiomyocyte apoptosis after myocardial ischemia/reperfusion injury in adult rats.
Qian L, Shi J, Zhang C, Lu J, Lu X, Wu K, Yang C, Yan D, Zhang C, You Q, Liu X. | 12/31/2016 |
| RACK1 scaffolds AGAP2 to FAK to regulate FAK activity and cell adhesion during the differentiation process. | RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
Dwane S, Durack E, O'Connor R, Kiely PA. | 06/28/2014 |
| this study shows that varicocoele downregulates AR expression, upregulates GPER and RACK1. This regulation of AR may play an important role in testicular dysfunction. | Experimental varicocoele in rats affects mechanisms that control expression and function of the androgen receptor.
Soares TS, Fernandes SA, Lima ML, Stumpp T, Schoorlemmer GH, Lazari MF, Porto CS. | 04/5/2014 |
| Differences in RACK1 levels/localization account for, in part, differential proliferative responses to NPY(1-36) and PYY(1-36) in SHR vs. WKY preglomerular vascular smooth muscle cells. | Role of RACK1 in the differential proliferative effects of neuropeptide Y(1-36) and peptide YY(1-36) in SHR vs. WKY preglomerular vascular smooth muscle cells.
Cheng D, Zhu X, Gillespie DG, Jackson EK., Free PMC Article | 05/18/2013 |
| CLCA splicing isoform is associated with adhesion through beta1-integrin and its scaffolding protein | CLCA splicing isoform associated with adhesion through β1-integrin and its scaffolding protein: specific expression in undifferentiated epithelial cells.
Yamazaki J, Okamura K, Uehara K, Hatta M., Free PMC Article | 05/4/2013 |
| the function of nuclear RACK1 is mediated through its interaction with 14-3-3zeta | Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.
Neasta J, Kiely PA, He DY, Adams DR, O'Connor R, Ron D., Free PMC Article | 05/12/2012 |
| RACK1 modulates proliferation of preglomerular microvascular smooth muscle cells and glomerular mesangial cells, likely via the inositol-1,4,5-trisphosphate receptor/calcium/calmodulin pathway. | Receptor for activated protein kinase C1 regulates cell proliferation by modulating calcium signaling.
Cheng D, Zhu X, Barchiesi F, Gillespie DG, Dubey RK, Jackson EK., Free PMC Article | 11/12/2011 |
| BDNF expression is epigenetically regulated via the scaffolding protein RACK1 | Epigenetic regulation of BDNF expression via the scaffolding protein RACK1.
He DY, Neasta J, Ron D., Free PMC Article | 07/26/2010 |
| RACK1 can influence cell size, cell survival, adhesion, migration, but its responses to IGF-I are independent of an association with the IGF-IR. | Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.
O'Donovan HC, Kiely PA, O'Connor R. | 01/21/2010 |
| RACK1 tethers the ERK pathway core kinases and channels signals from upstream activation by integrins to downstream targets at focal adhesions. | RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility.
Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ., Free PMC Article | 01/21/2010 |
| in astrocytes, RACK1 and PKC-betaII synchronous relocation is not essential for relocation of PKC-betaII to the plasma membrane | Translocation of protein kinase C-betaII in astrocytes requires organized actin cytoskeleton and is not accompanied by synchronous RACK1 relocation.
Pascale A, Alkon DL, Grimaldi M. | 01/21/2010 |
| analysis showed significant downregulation of RACK1 expression in the rat model of monocrotaline-induced PAH but not in pulmonary arterial smooth muscle cells from PAH patients | Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.
Zakrzewicz A, Hecker M, Marsh LM, Kwapiszewska G, Nejman B, Long L, Seeger W, Schermuly RT, Morrell NW, Morty RE, Eickelberg O. | 01/21/2010 |
| Overexpression of RACK1 or depletion of RACK1 by interference RNA markedly augments or diminishes Ca2+ release. | RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release.
Patterson RL, van Rossum DB, Barrow RK, Snyder SH., Free PMC Article | 01/21/2010 |