TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice.
Cui Y, Chen C, Tang Z, Yuan W, Yue K, Cui P, Qiu X, Zhang H, Li T, Zhu X, Luo J, Sun S, Li Y, Feng C, Peng L, Xie X, Guo Y, Xie Y, Jiang X, Qi Z, Thomson AW, Dai H., Free PMC Article

Myeloid Trem2 ameliorates the progression of metabolic dysfunction-associated steatotic liver disease by regulating macrophage pyroptosis and inflammation resolution.
Yu W, Zhang Y, Sun L, Huang W, Li X, Xia N, Chen X, Wikana LP, Xiao Y, Chen M, Han S, Wang Z, Pu L.

TREM2 protects against inflammation by regulating the release of mito-DAMPs from hepatocytes during liver fibrosis.
Shan S, Chao S, Liu Z, Wang S, Liu Z, Zhang C, Cheng D, Su Z, Song F.

TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas.
Zheng J, Wang L, Zhao S, Zhang W, Chang Y, Bosco DB, Huang T, Dheer A, Gao S, Xu S, Ayasoufi K, Al-Kharboosh R, Qi F, Xie M, Johnson AJ, Dong H, Quiñones-Hinojosa A, Wu LJ.,

TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells.
Huang P, Zhang Z, Zhang P, Feng J, Xie J, Zheng Y, Liang X, Zhu B, Chen Z, Feng S, Wang L, Lu J, Liu Y, Zhang Y., Free PMC Article

TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia.
Li Z, Yu S, Li L, Zhou C, Wang L, Tang S, Gu N, Zhang Z, Huang Z, Chen H, Tang W, Wang Y, Yang X, Sun X, Yan J., Free PMC Article

TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis.
Fang C, Zhong R, Lu S, Yu G, Liu Z, Yan C, Gao J, Tang Y, Wang Y, Zhao Q, Feng X., Free PMC Article

Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages.
Liang Y, Hu Y, Zhang J, Song H, Zhang X, Chen Y, Peng Y, Sun L, Sun Y, Xue R, Ji S, Li C, Rong Z, Yang B, Xu Y., Free PMC Article

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias.
Yin T, Yesiltepe M, D'Adamio L., Free PMC Article

TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Zhang N, Ji Q, Chen Y, Wen X, Shan F., Free PMC Article

Dynamics of host immune responses and a potential function of Trem2(hi) interstitial macrophages in Pneumocystis pneumonia.
Yang HQ, Sun H, Li K, Shao MM, Zhai K, Tong ZH., Free PMC Article

TREM2 Alleviates Subarachnoid Hemorrhage-Induced Brain Injury through Attenuating Neuroinflammation and Programmed Cell Death in Vivo and in Vitro.
Liu J, Zhang Z, Zhou M, Ling S, Zhou X, Yuan B, Zhao X, Qi M, Han Y, Qin F, Li Z.

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2.
Yu C, Lad EM, Mathew R, Shiraki N, Littleton S, Chen Y, Hou J, Schlepckow K, Degan S, Chew L, Amason J, Kalnitsky J, Bowes Rickman C, Proia AD, Colonna M, Haass C, Saban DR.,

TREM2 gene induces differentiation of induced pluripotent stem cells into dopaminergic neurons and promotes neuronal repair via TGF-β activation in 6-OHDA-lesioned mouse model of Parkinson's disease.
Liang H, Liu P, Wang Z, Xiong H, Yin C, Zhao D, Wu C, Chen L., Free PMC Article

Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction.
Liang S, Xu L, Xin X, Zhang R, Wu Y., Free PMC Article

Effect of triggering receptor expressed on myeloid cells 2-associated alterations on lipid metabolism in macrophages in the development of non-alcoholic fatty liver disease.
Ji PX, Chen YX, Ni XX, Miao Q, Hua J.

Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.
Sun R, Lei C, Xu Z, Gu X, Huang L, Chen L, Tan Y, Peng M, Yaddanapudi K, Siskind L, Kong M, Mitchell R, Yan J, Deng Z., Free PMC Article

MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling.
Li X, Jia Y, Xiong M, Gao Y, Xu X, Ke C.

TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance.
Meng J, Han L, Xu H, Zhang L, Liu Z, Zhou Y, Zhang X, Luo H, Zhang YW.

Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.
Tagliatti E, Desiato G, Mancinelli S, Bizzotto M, Gagliani MC, Faggiani E, Hernández-Soto R, Cugurra A, Poliseno P, Miotto M, Argüello RJ, Filipello F, Cortese K, Morini R, Lodato S, Matteoli M., Free PMC Article

TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury.
Wei W, Zhang L, Xin W, Pan Y, Tatenhorst L, Hao Z, Gerner ST, Huber S, Juenemann M, Butz M, Huttner HB, Bähr M, Fitzner D, Jia F, Doeppner TR.

TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization.
Qu S, Hu S, Xu H, Wu Y, Ming S, Zhan X, Wang C, Huang X.,

Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion.
Pang XW, Chu YH, Zhou LQ, Chen M, You YF, Tang Y, Yang S, Zhang H, Xiao J, Deng G, Wang W, Shang K, Qin C, Tian DS.

Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure.
Smart CD, Fehrenbach DJ, Wassenaar JW, Agrawal V, Fortune NL, Dixon DD, Cottam MA, Hasty AH, Hemnes AR, Doran AC, Gupta DK, Madhur MS., Free PMC Article

Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome.
Shu X, Wei C, Tu WY, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B, Xu ZZ, Zhang K, Shen C.