| Characterization of neutral sphingomyelinase activity and isoform expression in rodent skeletal muscle mitochondria. | Characterization of neutral sphingomyelinase activity and isoform expression in rodent skeletal muscle mitochondria.
Silvera S, Wilkinson JA, LeBlanc PJ. | 01/29/2022 |
| Data herein confirm the role of ceramide in increased apoptotic cell death and highlight the protective effect of N-SMase inhibition in down-regulation of apoptotic stimuli responses occurring in hepatic ischemia reperfusion injury. | Neutral sphingomyelinase inhibition alleviates apoptosis, but not ER stress, in liver ischemia-reperfusion injury.
Tuzcu H, Unal B, Kırac E, Konuk E, Ozcan F, Elpek GO, Demir N, Aslan M. | 08/5/2017 |
| ANG II stimulates ceramide formation via the activation of nSMase in the kidney. | Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway.
Bautista-Pérez R, del Valle-Mondragón L, Cano-Martínez A, Pérez-Méndez O, Escalante B, Franco M. | 08/8/2015 |
| Data suggest that neurotrophins can promote cell viability through Trk receptors in a manner depending on basal neutral sphingomyelinase (nSMase) but not through SMase activity enhancement. | Trk receptors need neutral sphingomyelinase activity to promote cell viability.
Candalija A, Cubí R, Ortega A, Aguilera J, Gil C. | 03/1/2014 |
| results indicate that endothelin-1 stimulates arterial VCAM-1 expression through p38MAPK-dependent activation of neutral sphingomyelinases | Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase.
Ohanian J, Forman SP, Katzenberg G, Ohanian V. | 09/22/2012 |
| nSMase-derived ceramide production and the activation of PKCzeta are early and necessary events in the signalling cascade of acute hypoxic pulmonary vasoconstriction. | Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction.
Cogolludo A, Moreno L, Frazziano G, Moral-Sanz J, Menendez C, Castañeda J, González C, Villamor E, Perez-Vizcaino F., Free PMC Article | 01/21/2010 |
| this report demonstrates that depletion of cellular GSH during aging plays an important role in regulating the hepatic response to IL-1beta by inducing NSMase-2 activity. | Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation.
Rutkute K, Asmis RH, Nikolova-Karakashian MN., Free PMC Article | 01/21/2010 |
| Smpd2 inhibition participates in the benefits of acetylcysteine treatment in post-myocardial infarction in failing heart rats. | Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats.
Adamy C, Mulder P, Khouzami L, Andrieu-abadie N, Defer N, Candiani G, Pavoine C, Caramelle P, Souktani R, Le Corvoisier P, Perier M, Kirsch M, Damy T, Berdeaux A, Levade T, Thuillez C, Hittinger L, Pecker F. | 01/21/2010 |
| These results show that the process of aging causes increased basal NSMase-2 activity in hepatocytes, which in turn leads to IRAK-1 stabilization, JNK potentiation, and ultimately IL-1beta hyperresponsiveness. | Aging in rat causes hepatic hyperresposiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2.
Rutkute K, Karakashian AA, Giltiay NV, Dobierzewska A, Nikolova-Karakashian MN. | 01/21/2010 |
| sphingomyelinase causes an increase in intracellular chloride, which is known to inhibit glycogen synthase phosphatase | Sphingomyelinase treatment of rat hepatocytes inhibits cell-swelling-stimulated glycogen synthesis by causing cell shrinkage.
Van Sluijters DA, Van Woerkom GM, Aerts JM, Meijer AJ. | 01/21/2010 |
| a novel physiological function as a new mechanosensor initiating the ERK cascade | Transient mechanoactivation of neutral sphingomyelinase in caveolae to generate ceramide.
Czarny M, Liu J, Oh P, Schnitzer JE. | 01/21/2010 |