| Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis. | Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
Li N, Ren P, Wang J, Zhu X, Qiao X, Zeng Z, Ye T, Wang S, Meng Z, Gan H, Liu S, Sun Y, Zhu X, Dou G, Gu R., Free PMC Article | 01/31/2024 |
| Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton. | Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton.
Szpak D, Turpin C, Goreke U, Bialkowska K, Bledzka KM, Verbovetskiy D, Mohandas N, Gurkan UA, Qin J, Plow EF, Pluskota E., Free PMC Article | 05/3/2023 |
| A Novel Deletion in FERMT3 Causes LAD-III in a Turkish Family. | A Novel Deletion in FERMT3 Causes LAD-III in a Turkish Family.
Köker N, Deveci İ, van Leeuwen K, Akbayram S, Roos D, Kuijpers TW, Köker MY. | 04/20/2023 |
| Blockage of PD-L1 by FERMT3-mediated Wnt/beta-catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells. | Blockage of PD-L1 by FERMT3-mediated Wnt/β-catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells.
Tang Y, Nan N, Gui C, Zhou X, Jiang W, Zhou X. | 08/13/2022 |
| FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/beta-catenin signaling. | FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-catenin signaling.
Su X, Chen J, Lin X, Chen X, Zhu Z, Wu W, Lin H, Wang J, Ye X, Zeng Y., Free PMC Article | 03/19/2022 |
| Kindlin-3 and RASSF6 are probable biomarkers for predicting metastasis in cutaneous melanoma. | Kindlin-3 and RASSF6 are probable biomarkers for predicting metastasis in cutaneous melanoma.
Bozdogan O, Guresci S, Öcalan D, Bozdogan N. | 01/29/2022 |
| Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. | Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
Kerr BA, Shi L, Jinnah AH, Harris KS, Willey JS, Lennon DP, Caplan AI, Byzova TV., Free PMC Article | 06/12/2021 |
| Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment. | Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.
Dudiki T, Mahajan G, Liu H, Zhevlakova I, Bertagnolli C, Nascimento DW, Kothapalli CR, Byzova TV., Free PMC Article | 05/22/2021 |
| Kindlin-3 recruitment to the plasma membrane precedes high-affinity beta2-integrin and neutrophil arrest from rolling. | Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling.
Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras AR, Ginsberg MH, Ley K., Free PMC Article | 04/17/2021 |
| Proteomics Profiling Reveals Insulin-Like Growth Factor 1, Collagen Type VI alpha-2 Chain, and Fermitin Family Homolog 3 as Potential Biomarkers of Plaque Erosion in ST-Segment Elevated Myocardial Infarction. | Proteomics Profiling Reveals Insulin-Like Growth Factor 1, Collagen Type VI α-2 Chain, and Fermitin Family Homolog 3 as Potential Biomarkers of Plaque Erosion in ST-Segment Elevated Myocardial Infarction.
Liu J, Wang S, Hou J, Cai H, Pan W, Dong H, Sun R, Dong H, Fang S, Yu B. | 12/5/2020 |
| Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. | Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway.
Chronopoulos A, Thorpe SD, Cortes E, Lachowski D, Rice AJ, Mykuliak VV, Róg T, Lee DA, Hytönen VP, Del Río Hernández AE., Free PMC Article | 11/28/2020 |
| Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the Cytoskeleton. | Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the Cytoskeleton.
Liu H, Zhu L, Dudiki T, Gabanic B, Good L, Podrez EA, Cherepanova OA, Qin J, Byzova TV., Free PMC Article | 10/24/2020 |
| Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. | Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state.
Bu W, Levitskaya Z, Loh ZY, Jin S, Basu S, Ero R, Yan X, Wang M, Ngan SFC, Sze SK, Tan SM, Gao YG., Free PMC Article | 08/29/2020 |
| FERMT3 mutation is associated with bleeding disorders. | Novel variants in FERMT3 and RASGRP2-Genetic linkage in Glanzmann-like bleeding disorders.
Manukjan G, Wiegering VA, Reindl T, Strauß G, Klopocki E, Schulze H, Andres O. | 04/25/2020 |
| these results demonstrate that kindlin-3 in neutrophils is involved in modulating reactive oxygen species and extracellular trap signaling | Kindlin-3 negatively regulates the release of neutrophil extracellular traps.
Xu Z, Ni B, Cao Z, Zielonka J, Gao J, Chen F, Kalyanaraman B, White GC, Ma YQ., Free PMC Article | 05/11/2019 |
| FERMT3 (kindlin-2) role in proline synthesis and tumor growth.Kindlin-2 binds PYCR1 and PYCR2 proteins. | Kindlin-2 links mechano-environment to proline synthesis and tumor growth.
Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y, Wu C., Free PMC Article | 04/13/2019 |
| In patients with dysfunctions of ORAI1, STIM1 or FERMT3, severe immunodeficiency is frequently linked to abnormal platelet activity. Measurement of thrombus formation at low shear rate confirmed a greater impairment of platelet functionality in the ORAI1 patients than in the STIM1 patient. For 3 patients/relatives with a FERMT3 mutation, all parameters of thrombus formation were strongly reduced. | Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies.
Nagy M, Mastenbroek TG, Mattheij NJA, de Witt S, Clemetson KJ, Kirschner J, Schulz AS, Vraetz T, Speckmann C, Braun A, Cosemans JMEM, Zieger B, Heemskerk JWM., Free PMC Article | 03/9/2019 |
| FERMT3 regulates glioma cell activity through integrin-mediated Wnt/beta-catenin signaling. | FERMT3 contributes to glioblastoma cell proliferation and chemoresistance to temozolomide through integrin mediated Wnt signaling.
Lu C, Cui C, Liu B, Zou S, Song H, Tian H, Zhao J, Li Y. | 06/2/2018 |
| Expression of Kindlin2 is associated with tumor grade. | Kindlin‑2 promotes clear cell renal cell carcinoma progression through the Wnt signaling pathway.
Li M, Pei X, Wang G, Zhan J, Du J, Jiang H, Tang Y, Zhang H, He H. | 04/28/2018 |
| this case report describes a female Thai patient who was diagnosed with leukocyte adhesion deficiency type III with a novel mutation in FERMT3, presenting with a humoral immune defect | Adaptive immune defects in a patient with leukocyte adhesion deficiency type III with a novel mutation in FERMT3.
Suratannon N, Yeetong P, Srichomthong C, Amarinthnukrowh P, Chatchatee P, Sosothikul D, van Hagen PM, van der Burg M, Wentink M, Driessen GJ, Suphapeetiporn K, Shotelersuk V. | 12/17/2016 |
| kindlin-3 plays an important role in maintaining a proper conformation of the resting alpha4beta1 to mediate both rolling and firm cell adhesion | Kindlin-3 Is Essential for the Resting α4β1 Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions.
Lu L, Lin C, Yan Z, Wang S, Zhang Y, Wang S, Wang J, Liu C, Chen J., Free PMC Article | 11/12/2016 |
| Kindlin-3 regulates c-Myc protein expression in the human chronic myeloid leukemia cell line K562. | Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells.
Qu J, Ero R, Feng C, Ong LT, Tan HF, Lee HS, Ismail MH, Bu WT, Nama S, Sampath P, Gao YG, Tan SM., Free PMC Article | 11/5/2016 |
| NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution. | NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.
Chua GL, Tan SM, Bhattacharjya S., Free PMC Article | 09/10/2016 |
| Suppression of the Kindlin-2-integrin beta1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma. | Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism.
Zhang HF, Alshareef A, Wu C, Li S, Jiao JW, Cao HH, Lai R, Xu LY, Li EM., Free PMC Article | 08/6/2016 |
| Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall. | Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, Kähönen M, Lehtimäki T, Hytönen VP. | 05/28/2016 |