| NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6-driven pyroptosis and inflammation. | NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6-driven pyroptosis and inflammation.
Sheng M, Huo S, Jia L, Weng Y, Liu W, Lin Y, Yu W., Free PMC Article | 07/9/2024 |
| Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IkappaBalpha axis in liver inflammation. | Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation.
Lin Y, Sheng M, Qin H, Zhang P, Wang C, Fu W, Meng X, Wang D, Hou Y., Free PMC Article | 11/28/2023 |
| Caspase-6 is a key regulator of cross-talk signal way in PANoptosis in cancer. | Caspase-6 is a key regulator of cross-talk signal way in PANoptosis in cancer.
Qi L, Wang L, Jin M, Jiang M, Li L, Li Y. | 06/16/2023 |
| Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: new sights to clinical decision-making. | Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: new sights to clinical decision-making.
Zhu J, Shi Y, Lan S, Wang J, Jiang F, Tang C, Cai Y, Pan Z, Jian H, Fang H, Zhang Y, Zhong F., Free PMC Article | 06/13/2023 |
| Role of cited-1 and caspase-6 expression in HELLP syndrome. | Role of cited-1 and caspase-6 expression in HELLP syndrome.
Öcal E, Alkan Akalın S, Aşır F. | 04/20/2023 |
| Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration. | Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration.
Zhou L, Nho K, Haddad MG, Cherepacha N, Tubeleviciute-Aydin A, Tsai AP, Saykin AJ, Jesper Sjöström P, LeBlanc AC., Free PMC Article | 10/30/2021 |
| Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. | Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits.
Noël A, Foveau B, LeBlanc AC., Free PMC Article | 09/18/2021 |
| Identification of Allosteric Inhibitors against Active Caspase-6. | Identification of Allosteric Inhibitors against Active Caspase-6.
Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC., Free PMC Article | 10/10/2020 |
| Results show that two Casp6 variants, Casp6-G66R and Casp6-R65W, have less self-processing and exogenous proteolytic activity than Casp6-WT and reveal a novel regulatory area of Casp6 activity. Furthermore, the existence of these Casp6 variants suggests that full Casp6 activity may be dispensable in humans. | Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC., Free PMC Article | 09/21/2019 |
| have identified an exosite on caspase-6 that is critical for protein substrate recognition and turnover and therefore highly relevant for diseases such as cancer in which caspase-6-mediated apoptosis is often disrupted, and in neurodegeneration in which caspase-6 plays a central role. | Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA., Free PMC Article | 04/13/2019 |
| The prodomain region was found to be intrinsically disordered independent of the activation state of caspase-6; however, its complete removal resulted in the protection of the adjacent 26-32 region, suggesting that this region may play a regulatory role. The molecular details of caspase-6 dynamics in solution provide a comprehensive scaffold for strategic design of therapeutic approaches for neurodegenerative disorders. | Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Dagbay KB, Hardy JA., Free PMC Article | 06/9/2018 |
| SMSr is a novel and specific substrate of caspase-6, a non-conventional effector caspase implicated in Huntington's and Alzheimer's diseases. | Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.
Cabukusta B, Nettebrock NT, Kol M, Hilderink A, Tafesse FG, Holthuis JCM., Free PMC Article | 04/7/2018 |
| Results support the possibility that the Casp6 activity in the anterior olfactory nucleus of the olfactory bulb reflects degeneration in the entorhinal cortex and suggest that Casp6 activity in the olfactory bulb could represent degeneration associated with cognitive decline and early Alzheimer disease. | Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.
Foveau B, Albrecht S, Bennett DA, Correa JA, LeBlanc AC., Free PMC Article | 10/28/2017 |
| These data suggest that caspase-6 deactivating mutations may contribute to multifactorial carcinogenic transformations. | Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.
Dagbay KB, Hill ME, Barrett E, Hardy JA., Free PMC Article | 09/2/2017 |
| Caspase-6 undergoes helix-strand transition upon substrate binding. Caspase-6 shows distinctive conformational dynamics in its 130's region Local pKa Values of Key Amino Acid Residues within the 130's Region Vary between the Unliganded (Helical) and the VEID-bound (Strand) States of Caspase-6 . | Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.
Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA., Free PMC Article | 06/24/2017 |
| Following specific binding to and internalization into HER2-overexpressing tumor cells, the e23sFv-Fdt-casp6 protein induced tumor cell apoptosis and inhibited the proliferation of HER2-overexpressing A172 and U251MG cells in vitro, but not in U87MG cells with undetectable HER2 | HER2-targeted recombinant protein immuno-caspase-6 effectively induces apoptosis in HER2-overexpressing GBM cells in vitro and in vivo.
Zhang L, Ren J, Zhang H, Cheng G, Xu Y, Yang S, Dong C, Fang D, Zhang J, Yang A. | 03/18/2017 |
| Results identified novel members of the CASP6 interactome and demonstrate that a number of them are involved in key signaling pathways observed in neurodegenerative diseases. | Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Riechers SP, Butland S, Deng Y, Skotte N, Ehrnhoefer DE, Russ J, Laine J, Laroche M, Pouladi MA, Wanker EE, Hayden MR, Graham RK. | 12/17/2016 |
| The ability of sox11 to reduce effector caspase activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox proteins also had the ability to reduce caspase-6 activity but to a lesser extent than sox11 | Sox11 Reduces Caspase-6 Cleavage and Activity.
Waldron-Roby E, Hoerauf J, Arbez N, Zhu S, Kulcsar K, Ross CA., Free PMC Article | 06/28/2016 |
| Caspase-6 plays a role in activating caspase-3 in Tau truncation. | A synergic role of caspase-6 and caspase-3 in Tau truncation at D421 induced by H2O 2.
Zhao H, Zhao W, Lok K, Wang Z, Yin M. | 02/14/2015 |
| unmodified STAT1 is cleaved at multiple sites by caspase-3 and caspase-6 in malignant undifferentiated hematopoietic cells | Caspase-3 and caspase-6 cleave STAT1 in leukemic cells.
Licht V, Noack K, Schlott B, Förster M, Schlenker Y, Licht A, Krämer OH, Heinzel T., Free PMC Article | 01/10/2015 |
| p53 activity is an important upstream regulator of caspase-6 activity in Huntington's disease. | p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Ehrnhoefer DE, Skotte NH, Ladha S, Nguyen YT, Qiu X, Deng Y, Huynh KT, Engemann S, Nielsen SM, Becanovic K, Leavitt BR, Hasholt L, Hayden MR. | 11/8/2014 |
| In this study, the crystal structure of a full-length CASP6 zymogen mutant, proCASP6H121A, was solved. | The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Cao Q, Wang XJ, Li LF, Su XD. | 09/6/2014 |
| Caspase-6 is likely important in most tissues during early development but is less involved in adult tissues | Expression and activation of caspase-6 in human fetal and adult tissues.
Godefroy N, Foveau B, Albrecht S, Goodyer CG, LeBlanc AC., Free PMC Article | 09/6/2014 |
| axon regeneration promoted by suppression of CASP2 and CASP6 is CNTF-dependent and mediated through the JAK/STAT signalling pathway | Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.
Vigneswara V, Akpan N, Berry M, Logan A, Troy CM, Ahmed Z., Free PMC Article | 08/30/2014 |
| Significant associations have been found between CpG sites and patient sex, including DNA methylation in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone. | Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans.
Carless MA, Kulkarni H, Kos MZ, Charlesworth J, Peralta JM, Göring HH, Curran JE, Almasy L, Dyer TD, Comuzzie AG, Mahaney MC, Blangero J., Free PMC Article | 06/7/2014 |