| Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression. | Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
Braun C, Parks XX, Qudsi H, Lopes CMB., Free PMC Article | 01/15/2022 |
| KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea. | KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.
Redford KE, Rognant S, Jepps TA, Abbott GW., Free PMC Article | 09/4/2021 |
| The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function. | The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function.
Vay SU, Flitsch LJ, Rabenstein M, Monière H, Jakovcevski I, Andjus P, Bijelic D, Blaschke S, Walter HL, Fink GR, Schroeter M, Rueger MA., Free PMC Article | 01/9/2021 |
| Smooth muscle cell contractility was inhibited by treatment with a KCNQ1 inhibitor. | KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro.
Huang KC, Li TM, Liu X, Chen JH, Chien WK, Shiao YT, Tsang H, Lin TH, Liao CC, Huang SM, Li JP, Lin CW, Lin JC, Lin CC, Lai CH, Cheng CF, Liang WM, Hung CH, Chen CC, Lin YJ, Tsai FJ. | 01/26/2019 |
| Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered. | Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
Zimmer J, Takahashi T, Hofmann AD, Puri P. | 12/2/2017 |
| In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress. | Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the I(Ks) Amplitude in Check Until When Larger I(Ks) Is Needed.
Jiang M, Wang Y, Tseng GN., Free PMC Article | 08/19/2017 |
| Activation of PPARbeta/delta prevents hyperglycaemia-induced impairment of Kv7 channels. | Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.
Morales-Cano D, Moreno L, Barreira B, Briones AM, Pandolfi R, Moral-Sanz J, Callejo M, Mondejar-Parreño G, Cortijo J, Salaices M, Duarte J, Perez-Vizcaino F, Cogolludo A. | 07/8/2017 |
| KV channel expression and activity were upregulated after YM155 treatment. Survivin may play a role in the pathogenesis of CH-PH. | YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels.
Fan Z, Liu B, Zhang S, Liu H, Li Y, Wang D, Liu Y, Li J, Wang N, Liu Y, Zhang B. | 08/20/2016 |
| The high expression and function of Kv7 channels in the left coronary artery and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone. | Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.
Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A. | 02/13/2016 |
| Kv7.1/Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. The lipid raft localization of Kv7.1/Kv7.5 heteromers provides efficient spatial and temporal regulation of smooth muscle function. | Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology.
Oliveras A, Roura-Ferrer M, Solé L, de la Cruz A, Prieto A, Etxebarria A, Manils J, Morales-Cano D, Condom E, Soler C, Cogolludo A, Valenzuela C, Villarroel A, Comes N, Felipe A. | 08/30/2014 |
| Data suggest that Kcnq1 channels expressed in arterial myocytes are functional ion channels. Although Kcnq1 channels do not appear to contribute to resting vascular tone, Kcnq1 activators are effective vasorelaxants. | Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.
Chadha PS, Zunke F, Davis AJ, Jepps TA, Linders JT, Schwake M, Towart R, Greenwood IA., Free PMC Article | 10/13/2012 |
| during the induction of LTP M(1) mAChRs enhance NMDAR opening by two distinct mechanisms namely inhibition of KCa2 and Kv7 channels. | Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus.
Petrovic MM, Nowacki J, Olivo V, Tsaneva-Atanasova K, Randall AD, Mellor JR., Free PMC Article | 08/4/2012 |
| both the voltage-dependence and kinetics of gating were found to depend on the relative densities of KCNQ1 and KCNE1, suggesting the heart rhythm may be regulated by the relative expression of the auxiliary subunit | Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.
Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY., Free PMC Article | 12/4/2010 |
| Identification of the KCNQ1/KCNE recycling pathway and its modulation by SGK provides a mechanistic insight into stress-induced modulation of KCNQ1/KCNE channels. | Serum- and glucocorticoid-inducible kinases (SGK) regulate KCNQ1/KCNE potassium channels.
Strutz-Seebohm N, Henrion U, Steinke K, Tapken D, Lang F, Seebohm G. | 01/21/2010 |
| These results suggest that although it is expressed in nearly all taste bud cells, the function of KCNQ1 is not required for gross taste bud development or peripheral taste transduction pathways. | Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences.
Wang H, Iguchi N, Rong Q, Zhou M, Ogunkorode M, Inoue M, Pribitkin EA, Bachmanov AA, Margolskee RF, Pfeifer K, Huang L., Free PMC Article | 01/21/2010 |
| KCNQ1 may account for zygomatic granule potassium conductance and contribute to pancreatic hormone-stimulated enzyme and fluid secretion. | Evidence for KCNQ1 K+ channel expression in rat zymogen granule membranes and involvement in cholecystokinin-induced pancreatic acinar secretion.
Lee WK, Torchalski B, Roussa E, Thévenod F. | 01/21/2010 |
| The purpose of this study was to investigate whether skeletal muscle Kv7.1 and Kv7.5 were involved during proliferation and myogenesis. | Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation.
Roura-Ferrer M, Solé L, Martínez-Mármol R, Villalonga N, Felipe A. | 01/21/2010 |
| Stimulation of KvLQT1 channels through autocrine activation of EGF receptors could play a crucial role in lung epithelia repair processes. | Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.
Trinh NT, Privé A, Kheir L, Bourret JC, Hijazi T, Amraei MG, Noël J, Brochiero E. | 01/21/2010 |
| analysis of female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts | Female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts.
O'Mahony F, Alzamora R, Betts V, LaPaix F, Carter D, Irnaten M, Harvey BJ. | 01/21/2010 |
| Expression of KCNQ1 and KCNE1 associated with early stages of spermatogenesis and with presence of undifferentiated healthy or neoplastic germ cells. KCNQ1/KCNE1 may be involved in K+ transport, probably during germ-cell development. | KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies.
Tsevi I, Vicente R, Grande M, López-Iglesias C, Figueras A, Capellà G, Condom E, Felipe A. | 01/21/2010 |
| the hormone-regulated subunit CHIF modulates the voltage sensitivity of the KCNQ channels, but so far evidence for an actual co-localization of CHIF and KCNQ1 channels in native tissue is lacking. | The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
Jespersen T, Grunnet M, Rasmussen HB, Jørgensen NB, Jensen HS, Angelo K, Olesen SP, Klaerke DA. | 01/21/2010 |
| resting membrane potential in stomach SMCs | Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle.
Ohya S, Asakura K, Muraki K, Watanabe M, Imaizumi Y. | 01/21/2010 |
| results suggest that 293B- and HMR1556-sensitive channels influence action potential duration and frequency and thus insulin secretion | Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.
Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F, Rösler M, Gerlach U, Heitzmann D, Warth R, Lang F. | 01/21/2010 |
| A truncated splice variant of KCNQ1 (tr-rKCNQ1) was expressed in fetal and neonatal hearts. When expressed along with full-length KCNQ1, it suppressed potassium currents, whether a regulatory subunit minK was co-expressed or not. | A truncated splice variant of KCNQ1 cloned from rat heart.
Yamada Y, Chen X, Kobayashi T, Kamada Y, Nagashima M, Tsutsuura M, Seki S, Yamakage M, Namiki A, Tohse N. | 01/21/2010 |
| KCNQ1-like channels are significant contributors to regulatory volume decrease (RVD)-induced potassium (K+) channel efflux in the intact perfused rat liver. | Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C.
Lan WZ, Wang PY, Hill CE. | 01/21/2010 |