| BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression. | BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.
Kang T, Qin X, Lei Q, Yang Q. | 10/11/2023 |
| Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo. | Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo.
Zhang L, Dong W, Ma Y, Bai L, Zhang X, Sun C, Li J, Zhang L. | 06/18/2022 |
| resveratrol exhibits an effect on attenuating the retinal inflammatory condition and damage of DR via PON1. Our study suggests that resveratrol-induced PON1 in the retina may be a promising therapeutic strategy to prevent diabetes-related retinopathy. | Resveratrol exhibits an effect on attenuating retina inflammatory condition and damage of diabetic retinopathy via PON1.
Chen Y, Meng J, Li H, Wei H, Bi F, Liu S, Tang K, Guo H, Liu W. | 02/15/2020 |
| Study indicates that low PON1 expression is predictive of severe IVDD; PON1 plays an important role of keeping the homeostatic balance of intervertebral discs. | Paraoxonase 1 Was Negatively Associated With Intervertebral Disc Degeneration.
Chen F, Liu H, Li Z, Pei Y, Wang H, Zhang J, Wang J, Zheng Z. | 01/11/2020 |
| results indicate that PON1 functions as a novel regulator of T cell development. | Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage.
Bai L, Shi G, Ma Y, Zhang L, Guan F, Zhang X, Xu Y, Chen H, Zhang L., Free PMC Article | 10/26/2019 |
| 18beta-GA has a protective effect on MTX-induced nephrotoxicity with possible mechanisms of attenuating oxidative stress and inflammation through up-regulating the Nrf2/ARE signaling | 18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
Abd El-Twab SM, Hozayen WG, Hussein OE, Mahmoud AM. | 04/15/2017 |
| Compared with the rats in the control group, the serum activity of xanthine oxidase was significantly higher and that of PON1 was significantly lower in the rats in the model nonalcoholic fatty liver disease group (P<0.01). | Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease.
Wang B, Yang RN, Zhu YR, Xing JC, Lou XW, He YJ, Ding QL, Zhang MY, Qiu H. | 04/1/2017 |
| Acai extract increased serum PON1 activity and reduced hepatic steatosis and hepatic injury in rats fed a high fat diet. | Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats.
Pereira RR, de Abreu IC, Guerra JF, Lage NN, Lopes JM, Silva M, de Lima WG, Silva ME, Pedrosa ML., Free PMC Article | 03/18/2017 |
| investigated the changes in plasma PON1 activity, LDL oxidation, radical scavenging activity and lipid peroxidation in D-galactose-induced aging model and also compared the results with 24-month naturally aged rats | Plasma paraoxonase 1 arylesterase activity in D-galactose-induced aged rat model: correlation with LDL oxidation and redox status.
Kumar D, Rizvi SI. | 05/16/2015 |
| Study documented, for the first time, the presence of PON3 in rat serum and, notably, found that the upregulation of PON3, rather than PON1, appears to be associated with physical training. | Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat.
Romani R, De Medio GE, di Tullio S, Lapalombella R, Pirisinu I, Margonato V, Veicsteinas A, Marini M, Rosi G., Free PMC Article | 11/27/2010 |
| High omega-3 PUFA and ethanol decreased liver PON1 mRNA expression. Betaine restored liver PON1 mRNA expressions in low and high omega-3 PUFA ETOH groups. | Betaine protects chronic alcohol and omega-3 PUFA-mediated down-regulations of PON1 gene, serum PON1 and homocysteine thiolactonase activities with restoration of liver GSH.
Varatharajalu R, Garige M, Leckey LC, Gong M, Lakshman MR. | 08/9/2010 |
| increased N-homocysteinylation of plasma proteins in chronic hyperleptinemia caused by impairment of the animal's ability to hydrolyze homocysteine-thiolactone by PON1 | Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.
Beltowski J, Wójcicka G, Jakubowski H. | 03/8/2010 |
| suggest a hepato-protective role for PON1 against inflammation, fibrosis and liver disease mediated by MCP-1. | Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease.
Marsillach J, Camps J, Ferré N, Beltran R, Rull A, Mackness B, Mackness M, Joven J., Free PMC Article | 01/21/2010 |
| Report gender related differences in paraoxonase 1 response to high-fat diet-induced oxidative stress. | Gender related differences in paraoxonase 1 response to high-fat diet-induced oxidative stress.
Thomàs-Moyà E, Gómez-Pérez Y, Fiol M, Gianotti M, Lladó I, Proenza AM. | 01/21/2010 |
| Reduction in PON1 activity during Nippostrongylusbrasiliensis infection may be associated with inflammatory reactions. mounted against the parasites. | Decreased serum paraoxonase-1 activity during intestinal nematode (Nippostrongylus brasiliensis) infection in rats.
Farid AS, Nakahara K, Murakami N, Hayashi T, Horii Y. | 01/21/2010 |
| Serum paraoxonase activities were increased in a dose-dependent manner in taurine-treated hypothyroid rats. | High-dose taurine supplementation increases serum paraoxonase and arylesterase activities in experimental hypothyroidism.
Dirican M, Taş S, Sarandöl E. | 01/21/2010 |
| Result suggests that PON1 modulation is not an integral part of the main antioxidant mechanisms of caloric restriction. | The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats.
Thomàs-Moyà E, Gianotti M, Proenza AM, Lladó I. | 01/21/2010 |
| Delivery of the PON-1 gene may be a possible therapeutic strategy for preventing atherosclerosis. | Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet.
Miyoshi M, Nakano Y, Sakaguchi T, Ogi H, Oda N, Suenari K, Kiyotani K, Ozono R, Oshima T, Yoshida T, Chayama K. | 01/21/2010 |
| Serum PON1 activity increases within the first hours of fasting, representing a prompt adaptation designed to attenuate blood lipid peroxidation that cannot be sustained when fasting is prolonged | Time-dependent modulation of rat serum paraoxonase 1 activity by fasting.
Thomàs-Moyà E, Nadal-Casellas A, Gianotti M, Lladó I, Proenza AM. | 01/21/2010 |
| increased PON1 level may have a function related to the well-known atherosclerosis resistance of rats | Iron-ascorbic acid-induced oxidant stress and its quenching by paraoxonase 1 in HDL and the liver: comparison between humans and rats.
Trudel K, Sinnett D, James RW, Delvin E, Amre D, Seidman E, Levy E. | 01/21/2010 |
| caloric restriction reduced serum Paraoxonase 1 (PON1) activity and showed gender-related differences that are indicative of a different adaptive strategy of male and female rats when faced with a period of food restriction | Effects of caloric restriction and gender on rat serum paraoxonase 1 activity.
Thomàs-Moyà E, Gianotti M, Lladó I, Proenza AM. | 01/21/2010 |
| Consumption of pistachio as 20% of daily caloric intake increased serum PON1 activity by 35%. | Pistachio intake increases high density lipoprotein levels and inhibits low-density lipoprotein oxidation in rats.
Aksoy N, Aksoy M, Bagci C, Gergerlioglu HS, Celik H, Herken E, Yaman A, Tarakcioglu M, Soydinc S, Sari I, Davutoglu V. | 01/21/2010 |