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    ULK1 unc-51 like autophagy activating kinase 1 [ Homo sapiens (human) ]

    Gene ID: 8408, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in Epithelial Ovarian Carcinoma.

    CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in Epithelial Ovarian Carcinoma.
    Yong M, Zeng Y, Yao Y, Yang M, Tang F, Zhu H, Hu J., Free PMC Article

    10/25/2024
    MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy.

    MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy.
    Zhang Z, Liu X, Chu C, Zhang Y, Li W, Yu X, Han Q, Sun H, Zhang Y, Zhu X, Chen L, Wei R, Fan N, Zhou M, Li X., Free PMC Article

    10/11/2024
    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization.

    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization.
    Sankar DS, Kaeser-Pebernard S, Vionnet C, Favre S, de Oliveira Marchioro L, Pillet B, Zhou J, Stumpe M, Kovacs WJ, Kressler D, Antonioli M, Fimia GM, Dengjel J.

    10/2/2024
    WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation.

    WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation.
    Gubas A, Attridge E, Jefferies HB, Nishimura T, Razi M, Kunzelmann S, Gilad Y, Mercer TJ, Wilson MM, Kimchi A, Tooze SA., Free PMC Article

    09/17/2024
    SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.

    SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.
    Kong M, Chen Z, Lin Z, Yin P, Zhao Q.

    09/13/2024
    Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth in preclinical models of lung cancer.

    Inhibition of ULK1/2 and KRAS(G12C) controls tumor growth in preclinical models of lung cancer.
    Ghazi PC, O'Toole KT, Srinivas Boggaram S, Scherzer MT, Silvis MR, Zhang Y, Bogdan M, Smith BD, Lozano G, Flynn DL, Snyder EL, Kinsey CG, McMahon M., Free PMC Article

    09/4/2024
    IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.

    IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
    Liu K, Huang H, Xiong M, Wang Q, Chen X, Feng Y, Ma H, Chen W, Li X, Ye X., Free PMC Article

    04/18/2024
    Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.

    Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.
    Yang W, Qiu C, Lv H, Zhang Z, Yao T, Huang L, Wu G, Zhang X, Chen J, He Y., Free PMC Article

    04/4/2024
    RNF135 promotes cell proliferation and autophagy in lung adenocarcinoma by promoting the phosphorylation of ULK1.

    RNF135 promotes cell proliferation and autophagy in lung adenocarcinoma by promoting the phosphorylation of ULK1.
    Zhuang L, Shi G, Sun Y.

    03/28/2024
    SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.

    SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.
    Chen D, Wu J, Qiu X, Luo S, Huang S, Wei E, Qin M, Huang J, Liu S., Free PMC Article

    03/18/2024
    Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.

    Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.
    Wang J, Zheng F, Wang D, Yang Q., Free PMC Article

    02/21/2024
    DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser[56] to diminish pancreatic beta cell function upon overnutrition.

    DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.
    Lu Y, Xu J, Li Y, Wang R, Dai C, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R, Wu Q, Wu L, Meng Z, Tan M, Li J.

    02/20/2024
    AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.

    AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.
    Zhu L, Wang J, Wu Z, Chen S, He Y, Jiang Y, Luo G, Wu Z, Li Y, Xie J, Zou S, Zhou C., Free PMC Article

    02/15/2024
    Role of CircCHD2 in the pathogenesis of gestational diabetes mellitus by regulating autophagy via miR-33b-3p/ULK1 axis.

    Role of CircCHD2 in the pathogenesis of gestational diabetes mellitus by regulating autophagy via miR-33b-3p/ULK1 axis.
    Bao Y, Wu L, Liu Y, Fan C, Zhang J, Yang J.

    01/31/2024
    An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.

    An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
    Liang P, Zhang J, Wu Y, Zheng S, Xu Z, Yang S, Wang J, Ma S, Xiao L, Hu T, Jiang W, Huang C, Xing Q, Kundu M, Wang B., Free PMC Article

    11/7/2023
    Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway.

    Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway.
    Li X, Lin M, Liu M, Ye H, Qin S.

    10/28/2023
    ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation.

    ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation.
    Banerjee C, Mehra D, Song D, Mancebo A, Park JM, Kim DH, Puchner EM., Free PMC Article

    10/13/2023
    Transferrin promotes chondrogenic differentiation in condylar growth through inducing autophagy via ULK1-ATG16L1 axis.

    Transferrin promotes chondrogenic differentiation in condylar growth through inducing autophagy via ULK1-ATG16L1 axis.
    Wen X, Wang Y, Gu Y.

    09/25/2023
    ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.

    ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.
    Jia M, Yue X, Sun W, Zhou Q, Chang C, Gong W, Feng J, Li X, Zhan R, Mo K, Zhang L, Qian Y, Sun Y, Wang A, Zou Y, Chen W, Li Y, Huang L, Yang Y, Zhao Y, Cheng X., Free PMC Article

    06/16/2023
    Identification of ULK1 as a novel mitophagy-related gene in diabetic nephropathy.

    Identification of ULK1 as a novel mitophagy-related gene in diabetic nephropathy.
    Yang YY, Gao ZX, Mao ZH, Liu DW, Liu ZS, Wu P., Free PMC Article

    02/9/2023
    Vaspin Attenuates Atrial Abnormalities by Promoting ULK1/FUNDC1-Mediated Mitophagy.

    Vaspin Attenuates Atrial Abnormalities by Promoting ULK1/FUNDC1-Mediated Mitophagy.
    Zhu Y, Gu Z, Shi J, Chen C, Xu H, Lu Q., Free PMC Article

    12/3/2022
    BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy.

    BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy.
    Yang W, Cheng B, Chen P, Sun X, Wen Z, Cheng Y., Free PMC Article

    12/3/2022
    Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy.

    Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy.
    Zhang Z, Chen L, Chen X, Qin Y, Tian C, Dai X, Meng R, Zhong Y, Liang W, Shen C, Zhang J, Zhang B, Wei X.

    11/5/2022
    The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.

    The effect of lactoferrin on ULK1 and ATG13 genes expression in breast cancer cell line MCF7 and bioinformatics studies of protein interaction between lactoferrin and the autophagy initiation complex.
    Karabi Z, Moradian F, Kheirabadi M.

    10/22/2022
    ULK1 inhibition attenuates telomerase activity in hepatic cells.

    ULK1 inhibition attenuates telomerase activity in hepatic cells.
    Raza S, Rajak S, Srivastava J, Tewari A, Gupta P, Chakravarti B, Ghosh S, Chaturvedi CP, Sinha RA.

    10/15/2022
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