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    CASP8 caspase 8 [ Homo sapiens (human) ]

    Gene ID: 841, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Investigation of the association between the CASP8rs1045485 and SOD2 rs4880 single nucleotide polymorphisms (SNPs) with breast cancer.

    Investigation of the association between the CASP8rs1045485 and SOD2 rs4880 single nucleotide polymorphisms (SNPs) with breast cancer.
    Shikholeslami SR, Keshavarzi F.

    10/10/2024
    NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death.

    NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death.
    Hu S, Wang F, Mao L, Jiang X, Luo Y, Qin X, Zou Z, Chen C, Yu C, Zhang J.

    07/3/2024
    Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.

    Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
    Yang CY, Lien CI, Tseng YC, Tu YF, Kulczyk AW, Lu YC, Wang YT, Su TW, Hsu LC, Lo YC, Lin SC., Free PMC Article

    05/23/2024
    Role for Caspase-8 in the Release of IL-1beta and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection.

    Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection.
    Pandori WJ, Matsuno SY, Shin JH, Kim SC, Kao TH, Mallya S, Batarseh SN, Lodoen MB.,

    03/20/2024
    TNF and IFNgamma-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.

    TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
    Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y., Free PMC Article

    02/12/2024
    Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma.

    Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma.
    Peng F, Zhu F, Cao B, Peng L., Free PMC Article

    01/12/2024
    The role of caspase-8 in inflammatory signalling and pyroptotic cell death.

    The role of caspase-8 in inflammatory signalling and pyroptotic cell death.
    Pang J, Vince JE.

    12/21/2023
    Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide.

    Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide.
    Cristaldi M, Buscetta M, Cimino M, La Mensa A, Giuffrè MR, Fiore L, Carcione C, Bucchieri F, Rappa F, Coronnello C, Sciaraffa N, Amato S, Aronica TS, Lo Iacono G, Bertani A, Pace E, Cipollina C., Free PMC Article

    11/29/2023
    Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.

    Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.
    Li M, Zeng A, Tang X, Xu H, Xiong W, Guo Y., Free PMC Article

    11/29/2023
    Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.

    Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
    Luk CT, Chan CK, Chiu F, Shi SY, Misra PS, Li YZ, Pollock-Tahiri E, Schroer SA, Desai HR, Sivasubramaniyam T, Cai EP, Krishnamurthy M, Han DJ, Chowdhury A, Aslam R, Yuen DA, Hakem A, Hakem R, Woo M.

    11/22/2023
    Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFalpha, caspase 8, STAT3, and Akt pathways modulators.

    Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators.
    Amititeloaie C, Chelaru L, Geleţu GL, Sava A, Jităreanu A, Tibeică AM, Costuleanu M., Free PMC Article

    10/28/2023
    Triglyceride induces DNA damage leading to monocyte death by activating caspase-2 and caspase-8.

    Triglyceride induces DNA damage leading to monocyte death by activating caspase-2 and caspase-8.
    Jung BC, Kim HK, Kim SH, Kim YS., Free PMC Article

    10/23/2023
    Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjogren's Disease.

    Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
    Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, Atsumi T, Chiorini JA., Free PMC Article

    08/31/2023
    CASP8 Is a Potential Therapeutic Target and Is Correlated with Pyroptosis in Traumatic Brain Injury.

    CASP8 Is a Potential Therapeutic Target and Is Correlated with Pyroptosis in Traumatic Brain Injury.
    Zhao G, Fu Y, Yang C, Yang X, Hu X.

    06/7/2023
    Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.

    Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis.
    Chen J, Zhou Y, Sun Y, Yuan S, Kalla R, Sun J, Zhao J, Wang L, Chen X, Zhou X, Dai S, Zhang Y, Ho GT, Xia D, Cao Q, Liu Z, Larsson SC, Wang X, Ding K, Halfvarson J, Li X, Theodoratou E, Satsangi J., Free PMC Article

    05/8/2023
    MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection.

    MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection.
    Lei X, Chen Y, Lien E, Fitzgerald KA., Free PMC Article

    04/28/2023
    Genetic contribution of caspase-8 variants and haplotypes to breast cancer risk and prognosis: a case-control study in Iran.

    Genetic contribution of caspase-8 variants and haplotypes to breast cancer risk and prognosis: a case-control study in Iran.
    Afzaljavan F, Vahednia E, Barati Bagherabad M, Vakili F, Moezzi A, Hosseini A, Homaei Shandiz F, Kooshyar MM, Nassiri M, Pasdar A., Free PMC Article

    04/6/2023
    Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection.

    Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection.
    Acat M, Yıldız Gülhan P, Eröz R, Ertınmaz Özkan A, Koca O, Çınar C., Free PMC Article

    03/30/2023
    Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1beta release in X-linked inhibitor of apoptosis (XIAP) deficiency.

    Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency.
    Hughes SA, Lin M, Weir A, Huang B, Xiong L, Chua NK, Pang J, Santavanond JP, Tixeira R, Doerflinger M, Deng Y, Yu CH, Silke N, Conos SA, Frank D, Simpson DS, Murphy JM, Lawlor KE, Pearson JS, Silke J, Pellegrini M, Herold MJ, Poon IKH, Masters SL, Li M, Tang Q, Zhang Y, Rashidi M, Geng L, Vince JE., Free PMC Article

    03/3/2023
    Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy.

    Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy.
    Contadini C, Ferri A, Di Martile M, Cirotti C, Del Bufalo D, De Nicola F, Pallocca M, Fanciulli M, Sacco F, Donninelli G, Capone A, Volpe E, Keller N, Miki S, Kawauchi D, Stupack D, Furnari F, Barilà D., Free PMC Article

    03/1/2023
    Caspase-3, Caspase-8 and XIAP Gene Expression in the Placenta: Exploring the Causes of Spontaneous Preterm Labour.

    Caspase-3, Caspase-8 and XIAP Gene Expression in the Placenta: Exploring the Causes of Spontaneous Preterm Labour.
    Belousova V, Svitich O, Timokhina E, Ignatko I, Bogomazova I, Pesegova S, Silaeva T, Kuzmina T, Skorobogatova O., Free PMC Article

    02/4/2023
    CASP4 and CASP8 as newly defined autophagy-pyroptosis-related genes associated with clinical and prognostic features of renal cell carcinoma.

    CASP4 and CASP8 as newly defined autophagy-pyroptosis-related genes associated with clinical and prognostic features of renal cell carcinoma.
    Li T, Liu N, Zhang G, Chen M.

    01/21/2023
    PROGNOSTIC POTENTIAL OF LYMPHOCYTE-TO-MONOCYTE RATIO AND CASPASE-8 IN PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEVELOPMENT.

    PROGNOSTIC POTENTIAL OF LYMPHOCYTE-TO-MONOCYTE RATIO AND CASPASE-8 IN PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEVELOPMENT.
    Tverezovskyi VM, Kapustnyk VA, Shelest BO, Sadovenko OL.

    01/14/2023
    The Effect of Caspase 8, 9 Gene Polymorphisms on Non-Hodgkin Lymphoma Susceptibility and Clinical/Pathological Features.

    The Effect of Caspase 8, 9 Gene Polymorphisms on Non-Hodgkin Lymphoma Susceptibility and Clinical/Pathological Features.
    Barati F, Bahari G, Asadi A, Nakhaee A, Hashemi SM, Taheri M, Hashemi M., Free PMC Article

    01/11/2023
    Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4[+] effector memory T cells.

    Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4(+) effector memory T cells.
    Hu J, Huang Z, Yu M, Zhang P, Xia Z, Gao C., Free PMC Article

    01/11/2023
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