| Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/beta-catenin signaling. | Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/β-catenin signaling.
Boonsawat P, Asadollahi R, Niedrist D, Steindl K, Begemann A, Joset P, Bhoj EJ, Li D, Zackai E, Vetro A, Barba C, Guerrini R, Whalen S, Keren B, Khan A, Jing D, Palomares Bralo M, Rikeros Orozco E, Hao Q, Schlott Kristiansen B, Zheng B, Donnelly D, Clowes V, Zweier M, Papik M, Siegel G, Sabatino V, Mocera M, Horn AHC, Sticht H, Rauch A., Free PMC Article | 09/16/2024 |
| E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors. | E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors.
Bugter JM, van Kerkhof P, Jordens I, Janssen E, Tran Ngoc Minh T, Iglesias van Montfort D, Jamieson C, Maurice MM., Free PMC Article | 07/31/2024 |
| Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth. | Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Kschonsak YT, Gao X, Miller SE, Hwang S, Marei H, Wu P, Li Y, Ruiz K, Dorighi K, Holokai L, Perampalam P, Tsai WK, Kee YS, Agard NJ, Harris SF, Hannoush RN, de Sousa E Melo F. | 07/10/2024 |
| Comprehensive analysis of zinc and ring finger 3 in prognostic value and pan-cancer immunity. | Comprehensive analysis of zinc and ring finger 3 in prognostic value and pan-cancer immunity.
Liu M, Zhao H, Peng S, Wu Y, Liu Y, Sun W, Zen K, Sun X. | 03/13/2024 |
| Single-Exon Deletions of ZNRF3 Exon 2 Cause Congenital Adrenal Hypoplasia. | Single-Exon Deletions of ZNRF3 Exon 2 Cause Congenital Adrenal Hypoplasia.
Amano N, Narumi S, Aizu K, Miyazawa M, Okamura K, Ohashi H, Katsumata N, Ishii T, Hasegawa T. | 02/22/2024 |
| Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development. | Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development.
Rjiba K, Mougou-Zerelli S, Hamida IH, Saad G, Khadija B, Jelloul A, Slimani W, Hasni Y, Dimassi S, Khelifa HB, Sallem A, Kammoun M, Abdallah HH, Gribaa M, Bignon-Topalovic J, Chelly S, Khairi H, Bibi M, Kacem M, Saad A, Bashamboo A, McElreavey K., Free PMC Article | 03/8/2023 |
| RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state. | RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Belenguer G, Mastrogiovanni G, Pacini C, Hall Z, Dowbaj AM, Arnes-Benito R, Sljukic A, Prior N, Kakava S, Bradshaw CR, Davies S, Vacca M, Saeb-Parsy K, Koo BK, Huch M., Free PMC Article | 02/19/2022 |
| A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/beta-catenin signaling regulates the progression and temozolomide resistance in glioma. | A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/β-catenin signaling regulates the progression and temozolomide resistance in glioma.
Liu T, Hu J, Han B, Tan S, Jia W, Xin Y., Free PMC Article | 02/5/2022 |
| Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse. | Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse.
Fraser M, Livingstone J, Wrana JL, Finelli A, He HH, van der Kwast T, Zlotta AR, Bristow RG, Boutros PC., Free PMC Article | 12/4/2021 |
| MicroRNA301a/ZNRF3/wnt/betacatenin signal regulatory crosstalk mediates glioma progression. | MicroRNA‑301a/ZNRF3/wnt/β‑catenin signal regulatory crosstalk mediates glioma progression.
Sun J, Ma Q, Shu C, Xiong J, Li B, Wu J, Zhang S, Li J, Liu J, Wang J., Free PMC Article | 11/22/2021 |
| A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling. | A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling.
Kim M, Reinhard C, Niehrs C., Free PMC Article | 10/30/2021 |
| RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway. | RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.
Wang Z, Wang Y, Ma X, Dang C. | 08/14/2021 |
| The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. | The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C., Free PMC Article | 05/15/2021 |
| Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma. | Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma.
Brondani VB, Lacombe AMF, Mariani BMP, Montenegro L, Soares IC, Bezerra-Neto JE, Tanno FY, Srougi V, Chambo JL, Mendonca BB, Almeida MQ, Zerbini MCN, Fragoso MCBV., Free PMC Article | 04/17/2021 |
| miR106b3p promotes cell proliferation and invasion, partially by downregulating ZNRF3 and inducing EMT via Wnt/betacatenin signaling in esophageal squamous cell carcinoma cells. | Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma.
Qiao G, Dai C, He Y, Shi J, Xu C., Free PMC Article | 08/3/2019 |
| The ZNRF3 is ubiquitinated by beta-TRCP in both CKI-phosphorylation- and degron-dependent manners. | SCF(β-TRCP) E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation.
Ci Y, Li X, Chen M, Zhong J, North BJ, Inuzuka H, He X, Li Y, Guo J, Dai X., Free PMC Article | 07/27/2019 |
| results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers | RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B. | 11/24/2018 |
| The present study suggests rs7290117 in ZNRF3 may be involved in the regulation of axial length, though our results do not support a contribution of the SNPs we tested in ZNRF3, HGF and MFRP to primary angle-closure glaucoma in northern Chinese people | Association of Genes implicated in primary angle-closure Glaucoma and the ocular biometric parameters of anterior chamber depth and axial length in a northern Chinese population.
Wang S, Zhuang W, Ma J, Xu M, Piao S, Hao J, Zhang W, Chi H, Xue Z, Ha S., Free PMC Article | 11/10/2018 |
| Missense variants of ZNRF3 are associated with Disorders of Sex Development. | ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.
Harris A, Siggers P, Corrochano S, Warr N, Sagar D, Grimes DT, Suzuki M, Burdine RD, Cong F, Koo BK, Clevers H, Stévant I, Nef S, Wells S, Brauner R, Ben Rhouma B, Belguith N, Eozenou C, Bignon-Topalovic J, Bashamboo A, McElreavey K, Greenfield A., Free PMC Article | 09/22/2018 |
| Data suggest that inactivation of RNF43 and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype. | RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.
Bond CE, McKeone DM, Kalimutho M, Bettington ML, Pearson SA, Dumenil TD, Wockner LF, Burge M, Leggett BA, Whitehall VL., Free PMC Article | 03/3/2018 |
| ZNRF3 inhibited the metastasis and tumorigenesis via suppressing the Wnt/beta-catenin signaling pathway in NPC cells. | ZNRF3 Inhibits the Invasion and Tumorigenesis in Nasopharyngeal Carcinoma Cells by Inactivating the Wnt/β-Catenin Pathway.
Wang Z, Wang Y, Ren H, Jin Y, Guo Y., Free PMC Article | 11/4/2017 |
| Data indicate that clinical specimens showed a significant inverse correlation between zinc and ring finger 3 (ZNRF3) and beta-catenin mRNA levels. | ZNRF3 is downregulated in papillary thyroid carcinoma and suppresses the proliferation and invasion of papillary thyroid cancer cells.
Qiu W, Yang Z, Fan Y, Zheng Q. | 02/25/2017 |
| miR-93/ZNRF3/Wnt/beta-catenin regulatory network contributes to the growth of lung carcinoma. | ZNRF3 contributes to the growth of lung carcinoma via inhibiting Wnt/β-catenin pathway and is regulated by miR-93.
Shi J, Jiang X, Yu Z, He G, Ning H, Wu Z, Cai Y, Yu H, Chen A. | 02/18/2017 |
| ZnRF3 negatively influences both the Wnt and Hedgehog proliferative pathways, and probably this way it negatively regulates cancer progression. | ZnRF3 Induces Apoptosis of Gastric Cancer Cells by Antagonizing Wnt and Hedgehog Signaling.
Qin H, Cai A, Xi H, Yuan J, Chen L. | 01/28/2017 |
| ZnRF3 negatively influences both the Wnt and Hedgehog proliferative pathways and probably this way it negatively regulates cancer progression | ZnRF3 induces apoptosis of gastric cancer cells by antagonizing Wnt and Hedgehog signaling.
Qin H, Cai A, Xi H, Yuan J, Chen L. | 11/5/2016 |