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    SGIP1 SH3GL interacting endocytic adaptor 1 [ Homo sapiens (human) ]

    Gene ID: 84251, updated on 27-Aug-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.

    Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
    Xie GF, Xu YX, Xu F, Sun LY, Ye ZL, Ma JJ, Wang HY, Shao JY.

    02/13/2021
    Data indicate that cysteine C632 residue is important for the function of SH3 domain GRB2 like endophilin interacting protein 1 (SGIP1) during cellular endocytosis.

    SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis.
    Zhang Y, Feng Y, Xin Y, Liu X.

    06/1/2019
    The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.

    Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage.
    Chwedorowicz R, Raszewski G, Kapka-Skrzypczak L, Sawicki K, Studziński T.

    01/14/2017
    crystal structures of the SGIP1 mu homology domains in complex with peptides containing two DPF motifs, are reported.

    Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain.
    Shimada A, Yamaguchi A, Kohda D., Free PMC Article

    01/14/2017
    Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans

    Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass.
    Cummings N, Shields KA, Curran JE, Bozaoglu K, Trevaskis J, Gluschenko K, Cai G, Comuzzie AG, Dyer TD, Walder KR, Zimmet P, Collier GR, Blangero J, Jowett JB.

    06/23/2012
    The earlier implicated single nucleotide polymorphisms located in SGIP1 gene showed no association with alcohol dependence or theta electroencephalogram power.

    Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
    Derringer J, Krueger RF, Manz N, Porjesz B, Almasy L, Bookman E, Edenberg HJ, Kramer JR, Tischfield JA, Bierut LJ., Free PMC Article

    04/7/2012
    SGIP1 and the signaling adaptor Reps1 interact with ITSN1 in vivo.

    Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
    Dergai O, Novokhatska O, Dergai M, Skrypkina I, Tsyba L, Moreau J, Rynditch A.

    01/1/2011
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genome-wide association identifies candidate genes that influence the human electroencephalogram.
    Hodgkinson CA, Enoch MA, Srivastava V, Cummins-Oman JS, Ferrier C, Iarikova P, Sankararaman S, Yamini G, Yuan Q, Zhou Z, Albaugh B, White KV, Shen PH, Goldman D., Free PMC Article

    06/30/2010
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Gene variants associated with ischemic stroke: the cardiovascular health study.
    Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT Jr, Lumley T, Rice K, Tracy RP, Devlin JJ, Psaty BM.

    Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
    Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM.

    12/3/2008
    SGIP1alpha plays an essential role in clathrin-mediated endocytosis by interacting with phospholipids and Eps15.

    SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.
    Uezu A, Horiuchi A, Kanda K, Kikuchi N, Umeda K, Tsujita K, Suetsugu S, Araki N, Yamamoto H, Takenawa T, Nakanishi H.

    01/21/2010
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