| ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells. | ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
Yang J, Liu X, Sun Y, Zhang X, Zhao Y, Zhang H, Mei Q, Meng J, Zhang F, Zhang T., Free PMC Article | 06/26/2023 |
| Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5. | Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
Ouyang X, Shi G, Wang S, Chen L, Xu J, Xie D. | 11/5/2022 |
| ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway. | ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
Wang Y, Tan J, Li J, Chen H, Wang W., Free PMC Article | 01/29/2022 |
| MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer. | MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
Xu JH, Zhao JX, Jiang MY, Yang LP, Sun ML, Wang HW. | 03/20/2021 |
| LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis. | LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
Han Y, Liu Y, Yang C, Gao C, Guo X, Cheng J., Free PMC Article | 12/5/2020 |
| The data suggest that miR-376c-3p downregulated ING5 to exert protective effects against oxygen-glucose deprivation-induced cell injury in cultured human and rat cells. | Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.
Zhang H, Zhou J, Zhang M, Yi Y, He B., Free PMC Article | 05/16/2020 |
| ING5 forms homodimers through its N-terminal domain, which folds independently into an elongated coiled-coil structure. | The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
Ormaza G, Rodríguez JA, Ibáñez de Opakua A, Merino N, Villate M, Gorroño I, Rábano M, Palmero I, Vilaseca M, Kypta R, Vivanco MDM, Rojas AL, Blanco FJ. | 03/28/2020 |
| Results show that ING5 overexpression promotes phosphorylation-dependent degradation of beta-catenin, leading to downregulated Wnt/beta- catenin signaling and inhibition of lung cancer invasion and epithelial-mesenchymal transition. | ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway.
Liu XL, Meng J, Zhang XT, Liang XH, Zhang F, Zhao GR, Zhang T., Free PMC Article | 03/14/2020 |
| The Hepatitis B virus X protein (HBx) downregulates the expression of the miR-181b target gene ING5, resulting in the promotion of HCC cell proliferation. | Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5.
Xie X, Xu X, Sun C, Yu Z. | 03/30/2019 |
| our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis | ING5 is a Potential Target for Osteosarcoma Therapy.
Zhang X, Xu ZH, Xie H, Sun YW, Liu J, Zhao YB., Free PMC Article | 12/22/2018 |
| ING5 promotes brain tumor initiating cells stemness by maintaining intracellular calcium levels and activating the follicle stimulating hormone pathway. | ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways.
Wang F, Wang AY, Chesnelong C, Yang Y, Nabbi A, Thalappilly S, Alekseev V, Riabowol K., Free PMC Article | 10/20/2018 |
| Nucleocytoplasmic translocation of ING5 protein occurs in breast cancer, and the high expression of nuclear ING5 is inversely related to some poor clinicopathological behaviors of breast cancer. | [Nucleocytoplasmic translocation of ING5 protein in breast cancer and its correlation with poor clinicopathological characteristics of breast cancer].
Song Y, Zhao S, Qi F, Zheng H. | 09/22/2018 |
| Overexpression of ING5 inhibited cell proliferation, neoplasm invasion and epithelial-mesenchymal transition of thyroid cancer cells. | Overexpression of ING5 inhibits HGF-induced proliferation, invasion and EMT in thyroid cancer cells via regulation of the c-Met/PI3K/Akt signaling pathway.
Gao W, Han J. | 08/18/2018 |
| We revealed that miR-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis | ING5 suppresses breast cancer progression and is regulated by miR-24.
Cui S, Liao X, Ye C, Yin X, Liu M, Hong Y, Yu M, Liu Y, Liang H, Zhang CY, Chen X., Free PMC Article | 02/24/2018 |
| ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway. | ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway.
Zhang GJ, Zhao J, Jiang ML, Zhang LC. | 02/17/2018 |
| Data suggest that inhibitor of growth protein 5 (ING5) downregulation might involved in carcinogenesis, growth, and invasion of lung cancer and could be considered as a promising marker to gauge the aggressiveness of lung cancer. | The down-regulated ING5 expression in lung cancer: a potential target of gene therapy.
Zhao S, Yang XF, Shen DF, Gao Y, Shi S, Wu JC, Liu HX, Sun HZ, Su RJ, Zheng HC., Free PMC Article | 02/3/2018 |
| miR-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR-1307 might serve as a therapeutic target for ovarian cancer. | MiR-1307 promotes ovarian cancer cell chemoresistance by targeting the ING5 expression.
Chen WT, Yang YJ, Zhang ZD, An Q, Li N, Liu W, Yang B., Free PMC Article | 04/8/2017 |
| miR-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression. | Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5.
Cao Y, Chen J, Wang D, Peng H, Tan X, Xiong D, Huang A, Tang H., Free PMC Article | 09/10/2016 |
| Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis. | ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.
Gou WF, Shen DF, Yang XF, Zhao S, Liu YP, Sun HZ, Su RJ, Luo JS, Zheng HC., Free PMC Article | 05/28/2016 |
| Loss of ING5 expression is associated with lung cancer. | ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.
Zhang F, Zhang X, Meng J, Zhao Y, Liu X, Liu Y, Wang Y, Li Y, Sun Y, Wang Z, Mei Q, Zhang T., Free PMC Article | 05/7/2016 |
| Identified ING5 as a novel CDK2 substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E/CDK2 and cyclin A/CDK2. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate. | ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53.
Linzen U, Lilischkis R, Pandithage R, Schilling B, Ullius A, Lüscher-Firzlaff J, Kremmer E, Lüscher B, Vervoorts J., Free PMC Article | 04/23/2016 |
| Results showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p's role in activating BCa chemoresistance. | The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer.
Li Y, Deng H, Lv L, Zhang C, Qian L, Xiao J, Zhao W, Liu Q, Zhang D, Wang Y, Yan J, Zhang H, He Y, Zhu J., Free PMC Article | 03/19/2016 |
| Data indicate that ING5 associates with Tip60 (KAT5) to form a complex with p53. | ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage.
Liu N, Wang J, Wang J, Wang R, Liu Z, Yu Y, Lu H. | 08/31/2013 |
| ING5 down-regulation promotes bone mesenchymal stem cell proliferation. | MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5.
Wang J, Huang W, Wu Y, Hou J, Nie Y, Gu H, Li J, Hu S, Zhang H., Free PMC Article | 01/26/2013 |
| Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. | The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
Zhang F, Bäumer N, Rode M, Ji P, Zhang T, Berdel WE, Müller-Tidow C., Free PMC Article | 12/31/2011 |