| CARD11 gain of function upregulates BCL2A1 expression and promotes resistance to targeted therapies combination in B-cell lymphoma. | CARD11 gain of function upregulates BCL2A1 expression and promotes resistance to targeted therapies combination in B-cell lymphoma.
Decombis S, Bellanger C, Le Bris Y, Madiot C, Jardine J, Santos JC, Boulet D, Dousset C, Menard A, Kervoelen C, Douillard E, Moreau P, Minvielle S, Moreau-Aubry A, Tessoulin B, Roue G, Bidère N, Le Gouill S, Pellat-Deceunynck C, Chiron D. | 11/7/2023 |
| DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11. | DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
Loh JT, Teo JKH, Kannan S, Verma CS, Andiappan AK, Lim HH, Lam KP. | 11/3/2023 |
| A novel variant in caspase recruitment domain family member 11 highlights the variability of clinical manifestations and management in a three generation family. | A novel variant in caspase recruitment domain family member 11 highlights the variability of clinical manifestations and management in a three generation family.
Cros G, Chapdelaine H, Teira P, Fernandez I, Pastore Y, Haddad E, Touzot F. | 10/26/2023 |
| CARD11 dominant negative mutation leads to altered human Natural Killer cell homeostasis. | CARD11 dominant negative mutation leads to altered human Natural Killer cell homeostasis.
Baronio M, Gazzurelli L, Rezzola S, Rossi S, Tessarin G, Marinoni M, Salpietro A, Fiore M, Moratto D, Chiarini M, Badolato R, Parolini S, Tabellini G, Lougaris V. | 06/22/2023 |
| Very Early Onset Inflammatory Bowel Disease Caused by a Novel Dominant Negative Mutation of Caspase Recruitment Domain 11 (CARD11). | Very Early Onset Inflammatory Bowel Disease Caused by a Novel Dominant Negative Mutation of Caspase Recruitment Domain 11 (CARD11).
Hu W, Ye Z, Li P, Wang Y, Huang Y. | 03/3/2023 |
| Elevated IgE from attenuated CARD11 signaling: lessons from atopic mice and humans. | Elevated IgE from attenuated CARD11 signaling: lessons from atopic mice and humans.
Pomerantz JL, Milner JD, Snow AL., Free PMC Article | 12/17/2022 |
| A familial case of B-cell expansion with NF-kappaB and T-cell anergy caused by a G123D heterozygous missense mutation in the CARD11 gene. | A familial case of B-cell expansion with NF-κB and T-cell anergy caused by a G123D heterozygous missense mutation in the CARD11 gene.
Takase Y, Tanioka S, Ishimura M, Yoshiura KI, Mori Y, Sakaida E, Funakoshi Y, Moriuchi H. | 11/5/2022 |
| CARMA1 is required for Notch1-induced NF-kappaB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemia. | CARMA1 is required for Notch1-induced NF-κB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemia.
Zhang N, Xu J, Wang R, Pan T, Zhang H, Yin L, Yao Y, Xu L, Zhu S, Wu Q, Li Z, Liu X, Xu K, Niu M. | 02/19/2022 |
| CARD11 is a novel target of miR-181b that is upregulated in chronic lymphocytic leukemia. | CARD11 is a novel target of miR-181b that is upregulated in chronic lymphocytic leukemia.
Kou Z, Mao M, Liu H, Wang X, Wang Z, Gu Z, Lang T, Nie Y, Wang Y, Huang Q, An L, Zhang X, Fu L, Li Y. | 01/29/2022 |
| Reconsidering phosphorylation in the control of inducible CARD11 scaffold activity during antigen receptor signaling. | Reconsidering phosphorylation in the control of inducible CARD11 scaffold activity during antigen receptor signaling.
Pomerantz JL., Free PMC Article | 10/30/2021 |
| The mutational landscape of cold agglutinin disease: CARD11 and CXCR4 mutations are correlated with lower hemoglobin levels. | The mutational landscape of cold agglutinin disease: CARD11 and CXCR4 mutations are correlated with lower hemoglobin levels.
Małecka A, Trøen G, Delabie J, Małecki J, Østlie I, Tierens A, Randen U, Berentsen S, Tjønnfjord GE. | 09/25/2021 |
| A Novel, Heterozygous Three Base-Pair Deletion in CARD11 Results in B Cell Expansion with NF-kappaB and T Cell Anergy Disease. | A Novel, Heterozygous Three Base-Pair Deletion in CARD11 Results in B Cell Expansion with NF-κB and T Cell Anergy Disease.
Shields AM, Bauman BM, Hargreaves CE, Pollard AJ, Snow AL, Patel SY. | 07/3/2021 |
| Multiplexed Functional Assessment of Genetic Variants in CARD11. | Multiplexed Functional Assessment of Genetic Variants in CARD11.
Meitlis I, Allenspach EJ, Bauman BM, Phan IQ, Dabbah G, Schmitt EG, Camp ND, Torgerson TR, Nickerson DA, Bamshad MJ, Hagin D, Luthers CR, Stinson JR, Gray J, Lundgren I, Church JA, Butte MJ, Jordan MB, Aceves SS, Schwartz DM, Milner JD, Schuval S, Skoda-Smith S, Cooper MA, Starita LM, Rawlings DJ, Snow AL, James RG., Free PMC Article | 01/16/2021 |
| Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly. | Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.
Stinson JR, Dorjbal B, McDaniel DP, David L, Wu H, Snow AL., Free PMC Article | 01/9/2021 |
| CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons. | Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons.
Wang W, Chang X, Yao W, Wei N, Huo N, Wang Y, Wei Q, Liu H, Wang X, Zhang S, Yang Z, Xiao S., Free PMC Article | 06/6/2020 |
| Our results indicate that CARD11 has evolved to actively coordinate scaffold opening and the induction of enzymatic activity among recruited cofactors during antigen receptor signaling | Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling.
Wang Z, Hutcherson SM, Yang C, Jattani RP, Tritapoe JM, Yang YK, Pomerantz JL., Free PMC Article | 05/9/2020 |
| These results illuminate a broader phenotypic spectrum associated with CARD11 mutations in human subjects | Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease.
Dorjbal B, Stinson JR, Ma CA, Weinreich MA, Miraghazadeh B, Hartberger JM, Frey-Jakobs S, Weidinger S, Moebus L, Franke A, Schäffer AA, Bulashevska A, Fuchs S, Ehl S, Limaye S, Arkwright PD, Briggs TA, Langley C, Bethune C, Whyte AF, Alachkar H, Nejentsev S, DiMaggio T, Nelson CG, Stone KD, Nason M, Brittain EH, Oler AJ, Veltri DP, Leahy TR, Conlon N, Poli MC, Borzutzky A, Cohen JI, Davis J, Lambert MP, Romberg N, Sullivan KE, Paris K, Freeman AF, Lucas L, Chandrakasan S, Savic S, Hambleton S, Patel SY, Jordan MB, Theos A, Lebensburger J, Atkinson TP, Torgerson TR, Chinn IK, Milner JD, Grimbacher B, Cook MC, Snow AL., Free PMC Article | 04/25/2020 |
| MYD88, CARD11, and CD79B Oncogenic Mutations are Rare Events in the Indian Cohort of De Novo Nodal Diffuse Large B-Cell Lymphoma. | MYD88, CARD11, and CD79B Oncogenic Mutations are Rare Events in the Indian Cohort of De Novo Nodal Diffuse Large B-Cell Lymphoma.
Aggarwal V, Das A, Bal A, Srinivasan R, Das R, Prakash G, Malhotra P, Varma S. | 04/18/2020 |
| Deregulated CARD11, BCL10 or MALT1 (CBM) expression or CBM signaling have been associated with immunodeficiency, autoimmunity and cancer. (Review) | Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells.
Lork M, Staal J, Beyaert R. | 04/11/2020 |
| Study present a structure of the N-terminal region of CARD9, which exhibits an extensive autoinhibitory interface required to prevent constitutive activation in both CARD9 and CARD11 and define the distinct structural mechanisms of activation in CARD9 and CARD11 and demonstrate that, upon activation, both proteins form helical templates that directly nucleate Bcl10 polymerization. | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Holliday MJ, Witt A, Rodríguez Gama A, Walters BT, Arthur CP, Halfmann R, Rohou A, Dueber EC, Fairbrother WJ., Free PMC Article | 10/26/2019 |
| Studies indicate that caspase recruitment domain family, member 11 protein (CARD11) functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response [Review]. | Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease.
Bedsaul JR, Carter NM, Deibel KE, Hutcherson SM, Jones TA, Wang Z, Yang C, Yang YK, Pomerantz JL., Free PMC Article | 10/5/2019 |
| Data indicate the importance of "tuning" caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) complex (CBM) signaling to preserve immune homeostasis [Review]. | The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex.
Lu HY, Bauman BM, Arjunaraja S, Dorjbal B, Milner JD, Snow AL, Turvey SE., Free PMC Article | 10/5/2019 |
| The CARD11 defect altered the classical nuclear factor kappaB pathway. | Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11).
Dadi H, Jones TA, Merico D, Sharfe N, Ovadia A, Schejter Y, Reid B, Sun M, Vong L, Atkinson A, Lavi S, Pomerantz JL, Roifman CM. | 08/3/2019 |
| The results indicate that CARD11 gene is one of the mutated genes involved in Turner syndrome. | Rare copy number variants in the genome of Chinese female children and adolescents with Turner syndrome.
Li L, Li Q, Wang Q, Liu L, Li R, Liu H, He Y, Lash GE., Free PMC Article | 08/3/2019 |
| The results suggest therefore that CARD11 mutations may help to diagnose CAD and better distinguish it from lymphoplasmacytic lymphoma. | Frequent somatic mutations of KMT2D (MLL2) and CARD11 genes in primary cold agglutinin disease.
Małecka A, Trøen G, Tierens A, Østlie I, Małecki J, Randen U, Wang J, Berentsen S, Tjønnfjord GE, Delabie JMA. | 07/20/2019 |