| HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion. | HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
Zhao X, Liu D, Zhao Y, Wang Z, Wang Y, Chen Z, Ning S, Wang G, Meng L, Yao J, Tian X., Free PMC Article | 02/23/2024 |
| Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery. | Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery.
Umphred-Wilson K, Adoro S., Free PMC Article | 02/6/2024 |
| Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders. | Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Wang HH, Lin LL, Li ZJ, Wei X, Askander O, Cappuccio G, Hashem MO, Hubert L, Munnich A, Alqahtani M, Pang Q, Burmeister M, Lu Y, Poirier K, Besmond C, Sun S, Brunetti-Pierri N, Alkuraya FS, Qi L., Free PMC Article | 01/26/2024 |
| Exogenous H2 S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration. | Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W., Free PMC Article | 01/6/2024 |
| SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma. | SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma.
Zhao M, Huang C, Yang L, Pan B, Yang S, Chang J, Jin Y, Zhao G, Yue D, Qie S, Ren L., Free PMC Article | 11/2/2023 |
| SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53. | SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53.
Che B, Du Y, Yuan R, Xiao H, Zhang W, Shao J, Lu H, Yu Y, Xiang M, Hao L, Zhang S, Du X, Liu X, Zhou W, Wang K, Chen L. | 11/1/2023 |
| Association between SYVN1 and SEL1 genetic polymorphisms and remission in rheumatoid arthritis patients treated with TNF-alpha inhibitors: a machine learning approach. | Association between SYVN1 and SEL1 genetic polymorphisms and remission in rheumatoid arthritis patients treated with TNF-α inhibitors: a machine learning approach.
Kim W, Yeon HR, Kim JH, Kim JH, Kim JH, Kim HA, Jung JY, Kim J, Choi IA, Lee KE. | 09/25/2023 |
| SYVN1 Promotes STAT3 Protein Ubiquitination and Exerts Antiangiogenesis Effects in Retinopathy of Prematurity Development. | SYVN1 Promotes STAT3 Protein Ubiquitination and Exerts Antiangiogenesis Effects in Retinopathy of Prematurity Development.
Chen S, Zhang J, Sun D, Wu Y, Fang J, Wan X, Li S, Zhang S, Gu Q, Shao Q, Dong J, Xu X, Wei F, Sun Q., Free PMC Article | 08/7/2023 |
| Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. | Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Liu Z, Nan P, Gong Y, Tian L, Zheng Y, Wu Z. | 06/26/2023 |
| miR-602 Activates NRF2 Antioxidant Pathways to Protect HBMECs from OGD/R-Induced Oxidative Stress via Targeting KEAP1 and HRD1. | miR-602 Activates NRF2 Antioxidant Pathways to Protect HBMECs from OGD/R-Induced Oxidative Stress via Targeting KEAP1 and HRD1.
Ma C, Yang L, Gao Q, Wang L., Free PMC Article | 10/15/2022 |
| The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission. | The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission.
Sun L, Ye H, Tian H, Xu L, Cai J, Zhang C, Wang R, Yang H, Zhao S, Zhang J, Gao S., Free PMC Article | 10/15/2022 |
| Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis. | Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis.
Cai Y, Jia Y., Free PMC Article | 02/26/2022 |
| HRD1-mediated METTL14 degradation regulates m(6)A mRNA modification to suppress ER proteotoxic liver disease. | HRD1-mediated METTL14 degradation regulates m(6)A mRNA modification to suppress ER proteotoxic liver disease.
Wei J, Harada BT, Lu D, Ma R, Gao B, Xu Y, Montauti E, Mani N, Chaudhuri SM, Gregory S, Weinberg SE, Zhang DD, Green R, He C, Fang D., Free PMC Article | 02/19/2022 |
| Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex. | Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex.
Kawaguchi K, Yamamoto-Hino M, Murakami Y, Kinoshita T, Goto S., Free PMC Article | 01/22/2022 |
| The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin-Mediated Degradation of 3-Hydroxy-3-Methylglutaryl CoA Reductase Degradation Protein 1. | The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin-Mediated Degradation of 3-Hydroxy-3-Methylglutaryl CoA Reductase Degradation Protein 1.
Yang Q, Chen X, Zhang Y, Hu S, Hu F, Huang Y, Ma T, Hu H, Tian H, Tian S, Ji YX, She ZG, Zhang P, Zhang XJ, Hu Y, Yang H, Yuan Y, Li H. | 01/15/2022 |
| Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. | Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression.
Fan Y, Wang J, Xu Y, Wang Y, Song T, Liang X, Jin F, Su D., Free PMC Article | 01/1/2022 |
| HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer. | HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer.
Guo X, Wang A, Wang W, Wang Y, Chen H, Liu X, Xia T, Zhang A, Chen D, Qi H, Ling T, Piao HL, Wang HJ., Free PMC Article | 11/27/2021 |
| Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis. | Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis.
Ji F, Zhou M, Sun Z, Jiang Z, Zhu H, Xie Z, Ouyang X, Zhang L, Li L., Free PMC Article | 10/23/2021 |
| CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer. | CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.
Fan Y, Wang J, Jin W, Sun Y, Xu Y, Wang Y, Liang X, Su D., Free PMC Article | 09/25/2021 |
| HRD1 prevents atherosclerosis-mediated endothelial cell apoptosis by promoting LOX-1 degradation. | HRD1 prevents atherosclerosis-mediated endothelial cell apoptosis by promoting LOX-1 degradation.
Li Q, Xuan W, Jia Z, Li H, Li M, Liang X, Su D., Free PMC Article | 08/28/2021 |
| Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function. | Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function.
Taguchi K, Kaneko M, Motoike S, Harada K, Hide I, Tanaka S, Sakai N. | 04/24/2021 |
| Sel1L-Hrd1 ER-associated degradation maintains beta cell identity via TGF-beta signaling. | Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling.
Shrestha N, Liu T, Ji Y, Reinert RB, Torres M, Li X, Zhang M, Tang CA, Hu CA, Liu C, Naji A, Liu M, Lin JD, Kersten S, Arvan P, Qi L., Free PMC Article | 02/6/2021 |
| The authors propose a mechanism of lung tumorigenesis that involves HRD1-mediated downregulation of SIRT2 and suggest that interventions targeting HRD1 activity could be a potential therapeutic strategy to treat patients with lung cancer. | E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation.
Liu L, Yu L, Zeng C, Long H, Duan G, Yin G, Dai X, Lin Z., Free PMC Article | 08/1/2020 |
| This structural analysis unveiled the position and range of the active site of HRD1_RING that contribute to its specific ubiquitin-conjugating enzyme (E2)-binding capability. | Unique RING finger structure from the human HRD1 protein.
Miyamoto K, Taguchi Y, Saito K., Free PMC Article | 01/25/2020 |
| association of the degradation factor HRD1 with the translocon and the rerouting factor Derlin-1 may be necessary for the smooth and effective clearance of ERpQC substrates | Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1.
Kadowaki H, Satrimafitrah P, Takami Y, Nishitoh H., Free PMC Article | 10/12/2019 |