| Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase. | Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.
Yoshida S, Kawamura A, Aoki K, Wiriyasermkul P, Sugimoto S, Tomiyoshi J, Tajima A, Ishida Y, Katoh Y, Tsukada T, Tsuneoka Y, Yamada K, Nagamori S, Nakayama K, Yoshida K., | 07/30/2024 |
| Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma. | Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma.
Harada E, Yoshida S, Imaizumi Y, Kawamura A, Ohtsuka T, Yoshida K. | 04/29/2024 |
| FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2. | FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.
Jiménez-Izquierdo R, Morrugares R, Suanes-Cobos L, Correa-Sáez A, Garrido-Rodríguez M, Cerero-Tejero L, Khan OM, de la Luna S, Sancho R, Calzado MA., Free PMC Article | 03/24/2023 |
| Dual inhibition of HSF1 and DYRK2 impedes cancer progression. | Dual inhibition of HSF1 and DYRK2 impedes cancer progression.
Tandon V, Moreno R, Allmeroth K, Quinn J, Wiley SE, Nicely LG, Denzel MS, Edwards J, de la Vega L, Banerjee S., Free PMC Article | 02/4/2023 |
| Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Wei T, Wang J, Liang R, Chen W, Chen Y, Ma M, He A, Du Y, Zhou W, Zhang Z, Zeng X, Wang C, Lu J, Guo X, Chen XW, Wang Y, Tian R, Xiao J, Lei X., Free PMC Article | 05/28/2022 |
| Combination of DYRK2 and TERT Expression Is a Powerful Predictive Marker for Early-stage Breast Cancer Recurrence. | Combination of DYRK2 and TERT Expression Is a Powerful Predictive Marker for Early-stage Breast Cancer Recurrence.
Tanaka M, Yamashita SI, Yoshinaga Y, Enomoto Y, Nohara Y, Ono S, Nabeshima K, Iwasaki A, Sato T. | 04/9/2022 |
| Frequent DYRK2 gene amplification in micropapillary element of lung adenocarcinoma - an implication in progression in EGFR-mutated lung adenocarcinoma. | Frequent DYRK2 gene amplification in micropapillary element of lung adenocarcinoma - an implication in progression in EGFR-mutated lung adenocarcinoma.
Koike C, Okudela K, Matsumura M, Mitsui H, Suzuki T, Arai H, Kataoka T, Ishikawa Y, Umeda S, Tateishi Y, Ohashi K. | 12/4/2021 |
| Emerging roles of DYRK2 in cancer. | Emerging roles of DYRK2 in cancer.
Tandon V, de la Vega L, Banerjee S., Free PMC Article | 07/31/2021 |
| Impairment of DYRK2 by DNMT1mediated transcription augments carcinogenesis in human colorectal cancer. | Impairment of DYRK2 by DNMT1‑mediated transcription augments carcinogenesis in human colorectal cancer.
Kumamoto T, Yamada K, Yoshida S, Aoki K, Hirooka S, Eto K, Yanaga K, Yoshida K. | 01/23/2021 |
| DYRK2 is strongly activated in normal or early-stage tumor cells, where they effectively degrade Snail through betaTrCP-mediated ubiquitination, thus suppressing epithelial-mesenchymal transition. | p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation That Is Required for GSK3β-βTrCP-Induced Snail Degradation.
Ryu KJ, Park SM, Park SH, Kim IK, Han H, Kim HJ, Kim SH, Hong KS, Kim H, Kim M, Yoon SJ, Asaithambi K, Lee KH, Park JY, Hah YS, Cho HJ, Yook JI, Yang JW, Ko GH, Lee G, Kang YJ, Hwangbo C, Kim KD, Park YJ, Yoo J. | 06/20/2020 |
| Especially in tumor cells, accumulating studies have revealed the molecular mechanisms of DYRK2 from the aspect of apoptosis, proliferation, EMT, and stem- ness. Considering in vitro and xenograft studies as well as down-regulation of DYRK2 in tumor specimens, DYRK2 is an important candidate for tumor suppressor. [review] | Multiple functions of DYRK2 in cancer and tissue development.
Yoshida S, Yoshida K. | 06/20/2020 |
| DYRK2 phosphorylates NDEL1 S336 to prime the phosphorylation of NDEL1 S332 by GSK3beta. The data suggest the NDEL1 phosphorylation at S336/S332 by the TARA-DYRK2-GSK3beta complex as a novel regulatory mechanism underlying neuronal morphogenesis. | Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.
Woo Y, Kim SJ, Suh BK, Kwak Y, Jung HJ, Nhung TTM, Mun DJ, Hong JH, Noh SJ, Kim S, Lee A, Baek ST, Nguyen MD, Choe Y, Park SK., Free PMC Article | 05/30/2020 |
| found that liver cancer patients with low DYRK2 expression had a significantly shorter overall survival | Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.
Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, Yoshida K. | 02/15/2020 |
| The expression level of DYRK2 was positively correlated with glioma pathological grade. | Regulation of Glioma Cells Migration by DYRK2.
Shen Y, Zhang L, Wang D, Bao Y, Liu C, Xu Z, Huang W, Cheng C. | 06/30/2018 |
| Results provide evidence that DYRK2 suppresses the proliferation of breast cancer cells and invasion through CDK14 expression. | Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer.
Imawari Y, Mimoto R, Hirooka S, Morikawa T, Takeyama H, Yoshida K., Free PMC Article | 02/10/2018 |
| Study found that DYRK2 regulates liver metastases of colorectal cancer cells through the activation of EMT, and that patients with low DYRK2-expressing colorectal cancer liver metastases had worse outcomes than those with high DYRK2-expressing metastases. | Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer.
Ito D, Yogosawa S, Mimoto R, Hirooka S, Horiuchi T, Eto K, Yanaga K, Yoshida K., Free PMC Article | 09/30/2017 |
| our results delineate a novel mechanism of cancer stem cell regulation by the DYRK2-AR-KLF4 axis. Restoration of the expression and function of DYRK2 is a potential therapeutic strategy against breast cancer stem cells. | Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer.
Mimoto R, Imawari Y, Hirooka S, Takeyama H, Yoshida K. | 09/2/2017 |
| lower DYRK2 levels were correlated with tumor sites, advanced clinical stages, and shorter survival in the advanced clinical stages. DYRK2 is a novel prognostic biomarker of human colorectal cancer. | Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.
Yan H, Hu K, Wu W, Li Y, Tian H, Chu Z, Koeffler HP, Yin D., Free PMC Article | 08/5/2017 |
| Diminished DYRK2 expression sensitizes hormone receptor-positive breast cancer to everolimus by preventing mTOR degradation. | Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR.
Mimoto R, Nihira NT, Hirooka S, Takeyama H, Yoshida K. | 08/5/2017 |
| Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage. | Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.
Yamamoto T, Taira Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T, Yoshida K. | 06/3/2017 |
| the downregulated expression of DYRK2 in HCC tumor tissues could promote the proliferation of hepatocellular carcinoma (HCC) cells. In addition, reducing DYRK2 expression was associated with poor prognosis and Oxaliplatin resistance in HCC. | Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma.
Zhang X, Xu P, Ni W, Fan H, Xu J, Chen Y, Huang W, Lu S, Liang L, Liu J, Chen B, Shi W. | 12/17/2016 |
| Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma | Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma.
Wang Y, Wu Y, Miao X, Zhu X, Miao X, He Y, Zhong F, Ding L, Liu J, Tang J, Huang Y, Xu X, He S. | 10/22/2016 |
| DYRK2 may regulate EMT through Snail degradation in ovarian SA and might be a predictive marker for a favorable prognosis in the treatment of this cancer. | DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma.
Yamaguchi N, Mimoto R, Yanaihara N, Imawari Y, Hirooka S, Okamoto A, Yoshida K. | 11/28/2015 |
| Downregulation of DYRK2 is associated with recurrence in early stage breast cancer. | Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer.
Enomoto Y, Yamashita S, Yoshinaga Y, Fukami Y, Miyahara S, Nabeshima K, Iwasaki A. | 04/18/2015 |
| DYRK2-dependent phosphorylation of pregnane X receptor facilitates its subsequent ubiquitination by UBR5. | Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.
Ong SS, Goktug AN, Elias A, Wu J, Saunders D, Chen T., Free PMC Article | 05/10/2014 |