| Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8[+] T cell expansion. | Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8(+) T cell expansion.
Yang Q, Patrick M, Lu J, Chen J, Zhang Y, Hemani H, Lehrmann E, De S, Weng NP., Free PMC Article | 02/29/2024 |
| HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy. | HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.
Kashyap S, Rabbani M, de Lima I, Kondrachuk O, Patel R, Shafiei MS, Mukker A, Rajakumar A, Gupta MK., Free PMC Article | 01/22/2022 |
| HOPX Exhibits Oncogenic Activity during Squamous Skin Carcinogenesis. | HOPX Exhibits Oncogenic Activity during Squamous Skin Carcinogenesis.
Pavlova O, Lefort K, Mariotto A, Huber M, Hohl D. | 12/18/2021 |
| Molecular basis of the interaction of Hsp90 with its co-chaperone Hop. | Molecular basis of the interaction of Hsp90 with its co-chaperone Hop.
Lott A, Oroz J, Zweckstetter M., Free PMC Article | 02/6/2021 |
| HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways. | HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways.
Hng CH, Camp E, Anderson P, Breen J, Zannettino A, Gronthos S., Free PMC Article | 01/2/2021 |
| Study revealed that ZNF750 is both necessary and sufficient for HOPX induction and propose that HOPX functions as a positive regulator of epidermal late differentiation within a p63-ZNF750-HOPX pathway to up-regulate the key proteins required for terminal epidermal differentiation, providing clarity to previous studies showing conflicting results. | HOPX Is a ZNF750 Target that Promotes Late Epidermal Differentiation.
Chen SY, Ishii MA, Cheng B, Otten ABC, Sun BK., Free PMC Article | 06/20/2020 |
| These data indicated that miR421 may act as an oncogene through the effects of HOPX on the Wnt/bcatenin signaling pathway and may provide insight into the mechanisms underlying carcinogenesis and the identification of potential biomarkers associated with nonsmall cell lung cancer (NSCLC). | ΜicroRNA‑421 promotes the progression of non‑small cell lung cancer by targeting HOPX and regulating the Wnt/β‑catenin signaling pathway.
Liang H, Wang C, Gao K, Li J, Jia R., Free PMC Article | 01/4/2020 |
| In idiopathic pulmonary fibrosis lungs, HOPX expression was decreased in whole lungs and significantly correlated to a decline in lung function and progression of IPF. HOPX is upregulated during early alveolar injury and repair process in the lung. Decreased HOPX expression might contribute to failed regenerative processes in end-stage IPF lungs. | Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis.
Ota C, Ng-Blichfeldt JP, Korfei M, Alsafadi HN, Lehmann M, Skronska-Wasek W, M De Santis M, Guenther A, Wagner DE, Königshoff M., Free PMC Article | 12/21/2019 |
| The hypertrophic signaling is not effectively activated during monolayer-based cardiac differentiation, thereby preventing expression of HOPX and its activation of downstream genes that govern late stages of cardiomyocyte maturation. | Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.
Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ., Free PMC Article | 10/26/2019 |
| In the present study, we compared the 2 potential epigenetic prognostic markers of CDO1 hypermethylation and HOPX hypermethylation using the same breast cancer samples, and the final focus was given on CDO1 hypermethylation | Differential Prognostic Relevance of Promoter DNA Methylation of CDO1 and HOPX in Primary Breast Cancer.
Tanaka Y, Kosaka Y, Waraya M, Yokota K, Harada H, Kaida T, Kikuchi M, Minatani N, Nishimiya H, Katoh H, Sengoku N, Watanabe M, Yamashita K. | 05/25/2019 |
| Data suggest that HOP homeobox HOPX (HOPX) acts as a tumour suppressor via the epigenetic regulation of snail family transcription factors (SNAIL) transcription and a prognostic biomarker for nasopharyngeal carcinoma (NPC) metastasis and therapeutic target for NPC treatment. | HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma.
Ren X, Yang X, Cheng B, Chen X, Zhang T, He Q, Li B, Li Y, Tang X, Wen X, Zhong Q, Kang T, Zeng M, Liu N, Ma J., Free PMC Article | 12/1/2018 |
| HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis | HOPX functions as a tumour suppressor in head and neck cancer.
Yap LF, Lai SL, Patmanathan SN, Gokulan R, Robinson CM, White JB, Chai SJ, Rajadurai P, Prepageran N, Liew YT, Lopes V, Wei W, Hollows RJ, Murray PG, Lambert DW, Hunter KD, Paterson IC., Free PMC Article | 07/14/2018 |
| The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol. | Free Energy of Binding and Mechanism of Interaction for the MEEVD-TPR2A Peptide-Protein Complex.
Lapelosa M. | 05/5/2018 |
| HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. | Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE., Free PMC Article | 04/28/2018 |
| HOPX is a distinctive homeobox gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML patients. | Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemia.
Lin CC, Hsu YC, Li YH, Kuo YY, Hou HA, Lan KH, Chen TC, Tzeng YS, Kuo YY, Kao CJ, Chuang PH, Tseng MH, Chiu YC, Chou WC, Tien HF., Free PMC Article | 03/17/2018 |
| HOPX has a role in the pathogenesis of skin cancers and skin diseases. | HOPX: The Unusual Homeodomain-Containing Protein.
Mariotto A, Pavlova O, Park HS, Huber M, Hohl D. | 09/16/2017 |
| these data indicate that the disruption of the PrP(C)-HOP complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC). | Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells.
de Lacerda TC, Costa-Silva B, Giudice FS, Dias MV, de Oliveira GP, Teixeira BL, Dos Santos TG, Martins VR. | 09/9/2017 |
| HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer. | Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer.
Kikuchi M, Katoh H, Waraya M, Tanaka Y, Ishii S, Tanaka T, Nishizawa N, Yokoi K, Minatani N, Ema A, Kosaka Y, Tanino H, Yamashita K, Watanabe M. | 08/5/2017 |
| Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis. | Extracting a low-dimensional description of multiple gene expression datasets reveals a potential driver for tumor-associated stroma in ovarian cancer.
Celik S, Logsdon BA, Battle S, Drescher CW, Rendi M, Hawkins RD, Lee SI., Free PMC Article | 02/25/2017 |
| The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene. | Association between non-coding polymorphisms of HOPX gene and syncope in hypertrophic cardiomyopathy.
Güleç Ç, Abacı N, Bayrak F, Kömürcü Bayrak E, Kahveci G, Güven C, Erginel Ünaltuna N. | 09/10/2016 |
| Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. | The joining of the Hsp90 and Hsp70 chaperone cycles yields transient interactions and stable intermediates: insights from mass spectrometry.
Schmidt C, Beilsten-Edmands V, Robinson CV., Free PMC Article | 05/21/2016 |
| HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. | HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer.
Chen Y, Yang L, Cui T, Pacyna-Gengelbach M, Petersen I. | 03/21/2015 |
| GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. | Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.
Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX., Free PMC Article | 08/31/2013 |
| HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC progression. | Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer.
Katoh H, Yamashita K, Waraya M, Margalit O, Ooki A, Tamaki H, Sakagami H, Kokubo K, Sidransky D, Watanabe M., Free PMC Article | 03/23/2013 |
| Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. | Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines.
Willmer T, Contu L, Blatch GL, Edkins AL. | 02/2/2013 |