| Here, genotype at an Osteoarthritis (OA) risk locus correlates with differential DNA methylation, with altered gene expression of both a transcriptional regulator (RUNX2), and a chromatin remodelling protein (SUPT3H). | Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk.
Rice SJ, Aubourg G, Sorial AK, Almarza D, Tselepi M, Deehan DJ, Reynard LN, Loughlin J., Free PMC Article | 03/30/2019 |
| significance of the formation PVT1- SUPT3H chimeric gene remains unknown and the overexpression of MYC by ectopic promoter on chromosome 6 may be essential to tumor genesis. | Identification of SUPT3H as a novel 8q24/MYC partner in blastic plasmacytoid dendritic cell neoplasm with t(6;8)(p21;q24) translocation.
Nakamura Y, Kayano H, Kakegawa E, Miyazaki H, Nagai T, Uchida Y, Ito Y, Wakimoto N, Mori S, Bessho M., Free PMC Article | 09/26/2015 |
| we identified rs41314453 as the main genetic determinant of ADAMTS13 activity, and we present preliminary findings for further associations at the ADAMTS13 and SUPT3H loci. | Genetic variants in the ADAMTS13 and SUPT3H genes are associated with ADAMTS13 activity.
de Vries PS, Boender J, Sonneveld MA, Rivadeneira F, Ikram MA, Rottensteiner H, Hofman A, Uitterlinden AG, Leebeek FW, Franco OH, Dehghan A, de Maat MP. | 08/29/2015 |
| identified a significant excess of genes with pivotal roles in bone homeostasis, such as PPPT3B and the height associated SUPT3H-RUNX2 | Adaptive evolution of loci covarying with the human African Pygmy phenotype.
Mendizabal I, Marigorta UM, Lao O, Comas D., Free PMC Article | 09/22/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Identification of 15 loci influencing height in a Korean population.
Kim JJ, Lee HI, Park T, Kim K, Lee JE, Cho NH, Shin C, Cho YS, Lee JY, Han BG, Yoo HW, Lee JK. | 12/2/2009 |
| Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article | 12/2/2009 |
| Found evidence of Mendelian Transmission Distortion in the region harboring SUPT3H in one HapMap population. | Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs.
Santos PS, Höhne J, Schlattmann P, König IR, Ziegler A, Uchanska-Ziegler B, Ziegler A, Santos PS, Höhne J, Schlattmann P, König IR, Ziegler A, Uchanska-Ziegler B, Ziegler A., Free PMC Articles: PMC2986600, PMC2986600 | 09/8/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs.
Santos PS, Höhne J, Schlattmann P, König IR, Ziegler A, Uchanska-Ziegler B, Ziegler A, Santos PS, Höhne J, Schlattmann P, König IR, Ziegler A, Uchanska-Ziegler B, Ziegler A., Free PMC Articles: PMC2986600, PMC2986600 | 03/25/2009 |
| suggest a novel STAF65gamma-dependent function of STAGA-type complexes in cell proliferation and transcription activation by MYC postloading of TFIID and RNA polymerase II that involves direct recruitment of core Mediator | STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.
Liu X, Vorontchikhina M, Wang YL, Faiola F, Martinez E., Free PMC Article | 01/21/2010 |