| Histidine triad nucleotide-binding protein 2: From basic science to clinical implications. | Histidine triad nucleotide-binding protein 2: From basic science to clinical implications.
Yao J, Miao Y, Zhu L, Wan M, Lu Y, Tang W. | 05/22/2023 |
| Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A. | Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Dolot R, Krakowiak A, Kaczmarek R, Włodarczyk A, Pichlak M, Nawrot B. | 11/22/2021 |
| Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A. | Histidine triad nucleotide-binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A.
Strom A, Tong CL, Wagner CR. | 05/8/2021 |
| Multivariate analyses revealed that tumor size and HINT2 expression are risk factors for Hepatocellular carcinoma recurrence. HINT2 is down-regulated in Hepatocellular carcinoma, and low HINT2 expression predicts earlier tumor recurrence. HINT2 expression may serve as a prognostic indicator of recurrence in Hepatocellular carcinoma. | Clinical significance of down-regulated HINT2 in hepatocellular carcinoma.
Zhou DK, Qian XH, Cheng J, Chen LH, Wang WL., Free PMC Article | 12/7/2019 |
| Decreased electron transfer and oxidative phosphorylation capacity in the absence of HINT-2. | The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism.
Rajasekaran R, Felser A, Nuoffer JM, Dufour JF, St-Pierre MV. | 03/16/2019 |
| Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression. | HINT2 triggers mitochondrial Ca(2+) influx by regulating the mitochondrial Ca(2+) uniporter (MCU) complex and enhances gemcitabine apoptotic effect in pancreatic cancer.
Chen L, Sun Q, Zhou D, Song W, Yang Q, Ju B, Zhang L, Xie H, Zhou L, Hu Z, Yao H, Zheng S, Wang W. | 12/9/2017 |
| HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion. | HINT2 downregulation promotes colorectal carcinoma migration and metastasis.
Li W, Cai S, Wang L, Yang C, Zhou B, Wang H., Free PMC Article | 09/23/2017 |
| Low HINT2 expression is associated with low response to therapy in endometrial cancer. | Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.
Lee LR, Teng PN, Nguyen H, Hood BL, Kavandi L, Wang G, Turbov JM, Thaete LG, Hamilton CA, Maxwell GL, Rodriguez GC, Conrads TP, Syed V. | 02/1/2014 |
| X-ray crystal structure of human HINT2 with and without bound AMP. | Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.
Maize KM, Wagner CR, Finzel BC., Free PMC Article | 09/14/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria. | Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis.
Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. | 01/21/2010 |