| The Genetic Confirmation and Clinical Characterization of LOXL3-Associated MYP28: A Common Type of Recessive Extreme High Myopia. | The Genetic Confirmation and Clinical Characterization of LOXL3-Associated MYP28: A Common Type of Recessive Extreme High Myopia.
Jiang Y, Zhou L, Wang Y, Ouyang J, Li S, Xiao X, Jia X, Wang J, Yi Z, Sun W, Jiao X, Wang P, Hejtmancik JF, Zhang Q., Free PMC Article | 03/21/2023 |
| LOXL3-promoted hepatocellular carcinoma progression via promotion of Snail1/USP4-mediated epithelial-mesenchymal transition. | LOXL3-promoted hepatocellular carcinoma progression via promotion of Snail1/USP4-mediated epithelial-mesenchymal transition.
Li R, Shang R, Li S, Ren Y, Shen L, Yang L, Chen S, Chen X, Li J, Xu M. | 09/24/2022 |
| Apoptosis Activation and Autophagy Inhibition of Chondrocytes by Leptin by the Upregulation of LOXL3 in Osteoarthritis Pathogenesis. | Apoptosis Activation and Autophagy Inhibition of Chondrocytes by Leptin by the Upregulation of LOXL3 in Osteoarthritis Pathogenesis.
Wei Q., Free PMC Article | 05/14/2022 |
| Identification of LOXL3-associating immune infiltration landscape and prognostic value in hepatocellular carcinoma. | Identification of LOXL3-associating immune infiltration landscape and prognostic value in hepatocellular carcinoma.
Wang N, Zhou X, Tang F, Wang X, Zhu X. | 01/22/2022 |
| LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells. | LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells.
Laurentino TS, Soares RDS, Lerario AM, Marie SKN, Oba-Shinjo SM., Free PMC Article | 09/11/2021 |
| we present here a child and his father with Stickler syndrome and homozygous novel mutation in LOXL3 c.1036C>T (p.Arg346Trp). This report adds more evidence that biallelic mutations in LOXL3 cause autosomal recessive Stickler syndrome. | LOXL3 novel mutation causing a rare form of autosomal recessive Stickler syndrome.
Chan TK, Alkaabi MK, ElBarky AM, El-Hattab AW. | 04/4/2020 |
| LOXL3 function beyond amino oxidase and role in pathologies, including cancer, has been described. (Review) | LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.
Laurentino TS, Soares RDS, Marie SKN, Oba-Shinjo SM., Free PMC Article | 12/28/2019 |
| results reveal an unexpected role for LOXL3 in the control of genome stability and melanoma progression, exposing its potential as a novel therapeutic target in malignant melanoma, a very aggressive condition yet in need for more effective treatment options. | Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.
Santamaría PG, Floristán A, Fontanals-Cirera B, Vázquez-Naharro A, Santos V, Morales S, Yuste L, Peinado H, García-Gómez A, Portillo F, Hernando E, Cano A., Free PMC Article | 09/21/2019 |
| LOXL1, LOXL3, and LOXL4 expressions are associated with distant metastasis of gastric cancer. | Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
Kasashima H, Yashiro M, Okuno T, Miki Y, Kitayama K, Masuda G, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Hirakawa K, Ohira M. | 03/23/2019 |
| Missense variant in LOXL3 gene is associated with nonsyndromic cleft palate. | Association between a common missense variant in LOXL3 gene and the risk of non-syndromic cleft palate.
Khan MFJ, Little J, Mossey PA, Steegers-Theunissen RPM, Bonsi M, Bassi Andreasi R, Rubini M. | 10/20/2018 |
| By deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, Loxl3 regulates Stat3 dimerization and transcriptional activity. CD4+ T cell differentiation in inflammatory responses is regulated by the Loxl3-Stat3 signaling pathway | Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation.
Ma L, Huang C, Wang XJ, Xin DE, Wang LS, Zou QC, Zhang YS, Tan MD, Wang YM, Zhao TC, Chatterjee D, Altura RA, Wang C, Xu YS, Yang JH, Fan YS, Han BH, Si J, Zhang X, Cheng J, Chang Z, Chin YE. | 10/7/2017 |
| Our results suggest that null mutations in LOXL3 are likely associated with autosomal recessive early-onset high myopia. LOXL3 is a potential candidate gene for high myopia, but this possibility should be confirmed in additional studies. | Exome sequencing identified null mutations in LOXL3 associated with early-onset high myopia.
Li J, Gao B, Xiao X, Li S, Jia X, Sun W, Guo X, Zhang Q., Free PMC Article | 10/22/2016 |
| LOXL3 is a novel candidate gene for autosomal recessive Stickler syndrome. | LOXL3, encoding lysyl oxidase-like 3, is mutated in a family with autosomal recessive Stickler syndrome.
Alzahrani F, Al Hazzaa SA, Tayeb H, Alkuraya FS. | 05/16/2015 |
| TGF-beta1 induced injured MCL to express more LOXs than injured ACL (up to 1.85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4). | TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury.
Xie J, Wang C, Huang DY, Zhang Y, Xu J, Kolesnikov SS, Sung KL, Zhao H. | 08/31/2013 |
| The human lysyl oxidase-like 3 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis. | Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.
McGregor TL, Gurnett CA, Dobbs MB, Wise CA, Morcuende JA, Morgan TM, Menon R, Muglia LJ., Free PMC Article | 10/15/2011 |
| Expression of LOXL, LOXL2, LOXL3 and LOXL4 was not statistically associated with tumor location, stage, growth type, or differentiation status in colorectal adenocarcinomas | Differential expression of the LOX family genes in human colorectal adenocarcinomas.
Kim Y, Roh S, Park JY, Kim Y, Cho DH, Kim JC. | 01/21/2010 |
| Breast carcinoma effusions showed significantly higher LOXL2 and lower LOXL3 expression compared to primary carcinomas. | Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities.
Sebban S, Davidson B, Reich R. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.
Akagawa H, Narita A, Yamada H, Tajima A, Krischek B, Kasuya H, Hori T, Kubota M, Saeki N, Hata A, Mizutani T, Inoue I. | 03/13/2008 |
| Lysyl-oxidase-like 3 interacts and cooperates with Snail to downregulate E-cadherin expression, and control epithelial-mesenchymal transitions and carcinoma progression. | A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.
Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, Csiszar K, Fong KS, Vega S, Nieto MA, Cano A, Portillo F., Free PMC Article | 01/21/2010 |
| LOXL3 encodes two variants, LOXL3 and LOXL3-sv1, both of which function as amine oxidases with distinct tissue and substrate specificities from one another. | A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity.
Lee JE, Kim Y. | 01/21/2010 |