| SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport. | SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.
Makio T, Zhang K, Love N, Mast FD, Liu X, Elaish M, Hobman T, Aitchison JD, Fontoura BMA, Wozniak RW., Free PMC Article | 04/12/2024 |
| Insights into the SARS-CoV-2 ORF6 Mechanism of Action. | Insights into the SARS-CoV-2 ORF6 Mechanism of Action.
Krachmarova E, Petkov P, Lilkova E, Ilieva N, Rangelov M, Todorova N, Malinova K, Hristova R, Nacheva G, Gospodinov A, Litov L., Free PMC Article | 08/19/2023 |
| Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients. | Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients.
Berkel C, Cacan E. | 07/21/2023 |
| Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer. | Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer.
Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K., Free PMC Article | 08/21/2021 |
| Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance. | Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.
Hu J, Xia X, Zhao Q, Li S., Free PMC Article | 08/7/2021 |
| Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex. | Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.
Kato K, Ikliptikawati DK, Kobayashi A, Kondo H, Lim K, Hazawa M, Wong RW., Free PMC Article | 01/16/2021 |
| RAE1 and NUP98 participate inBMAL1 shuttling and promote the degradation and activity of BMAL1 and CLOCK. | RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer.
Zheng X, Zhao X, Zhang Y, Tan H, Qiu B, Ma T, Zeng J, Tao D, Liu Y, Lu Y, Ma Y., Free PMC Article | 04/11/2020 |
| RAE1 overexpression was associated with considerably poorer disease-free survival and distant metastasis-free survival, especially in patients with oestrogen receptor-positive tumours. | The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition.
Oh JH, Hur H, Lee JY, Kim Y, Seo Y, Kim MH., Free PMC Article | 11/3/2018 |
| show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA). | USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.
Stockum A, Snijders AP, Maertens GN., Free PMC Article | 02/24/2018 |
| Nuclear export inhibition by ORF10 of human herpesvirus 8 requires an interaction with an RNA export factor, Rae1. | A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.
Gong D, Kim YH, Xiao Y, Du Y, Xie Y, Lee KK, Feng J, Farhat N, Zhao D, Shu S, Dai X, Chanda SK, Rana TM, Krogan NJ, Sun R, Wu TT., Free PMC Article | 09/9/2017 |
| After PSK administration, INF-g production in CD8(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model | Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Uchida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, Nagano H. | 08/12/2017 |
| Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 * Nup98). | Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 • Nup98).
Quan B, Seo HS, Blobel G, Ren Y., Free PMC Article | 08/23/2014 |
| vesicular stomatitis virus M protein interacted efficiently with Rae1-Nup98 complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription | Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription.
Rajani KR, Pettit Kneller EL, McKenzie MO, Horita DA, Chou JW, Lyles DS., Free PMC Article | 05/11/2013 |
| mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion | Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion.
Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH., Free PMC Article | 03/2/2013 |
| This study established a novel postmitotic function for rae-1 in neuronal development. | RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.
Grill B, Chen L, Tulgren ED, Baker ST, Bienvenut W, Anderson M, Quadroni M, Jin Y, Garner CC., Free PMC Article | 04/21/2012 |
| RAE1 transgene orchestrates proper chromosome segregation and NUP98-mediated leukemogenesis. | RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.
Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore MA, Sato H, Wong RW. | 03/17/2012 |
| In a transgenic mouse model of chronic natural killer NKG2D ligand expression, constant exposure to NKG2D ligand RNA export 1 homolog (Rae-1 epsilon) does not functionally impair NK cells or CD8-positive T cells in the context of viral infection. | Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.
Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL., Free PMC Article | 09/6/2010 |
| present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops. | Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.
Ren Y, Seo HS, Blobel G, Hoelz A., Free PMC Article | 07/26/2010 |
| Interaction between Rae1 and cohesin subunit SMC1 is required for proper spindle formation. | Interaction between Rae1 and cohesin subunit SMC1 is required for proper spindle formation.
Wong RW. | 03/15/2010 |
| Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. | Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.
Cuende J, Moreno S, Bolaños JP, Almeida A. | 01/21/2010 |
| point to the Rae1-NuMA interaction as a critical element for normal spindle formation in mitosis | Rae1 interaction with NuMA is required for bipolar spindle formation.
Wong RW, Blobel G, Coutavas E., Free PMC Article | 01/21/2010 |
| VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression. | VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway.
Faria PA, Chakraborty P, Levay A, Barber GN, Ezelle HJ, Enninga J, Arana C, van Deursen J, Fontoura BM. | 01/21/2010 |
| These data show an association of mrnp41 with MT and, moreover, demonstrate that an intact MT system is necessary for dispersion of mrnp41-containing particles to the cellular periphery | Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons.
Kraemer D, Dresbach T, Drenckhahn D. | 01/21/2010 |
| A purified Rae1 complex stabilizes microtubules in egg extracts in a RanGTP/importin beta-regulated manner | A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.
Blower MD, Nachury M, Heald R, Weis K. | 01/21/2010 |