| Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology. | Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.
Taylor D, Kneynsberg A, van Roijen M, Götz J., Free PMC Article | 01/21/2023 |
| Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism. | Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.
Chatterjee M, Singh P, Xu J, Lombroso PJ, Kurup PK., Free PMC Article | 10/9/2021 |
| PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis. | PTPN5 promotes follicle-stimulating hormone secretion through regulating intracellular calcium homeostasis.
Wang H, Bu S, Tang J, Li Y, Liu C, Dong J. | 07/31/2021 |
| that STEP61 is the molecular brake that is lost following KCC2-dependent disinhibition and that the decrease in STEP61 activity drives the potentiation of excitatory GluN2B NMDAR responses in rodent and human models of pathological pain | Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.
Dedek A, Xu J, Kandegedara CM, Lorenzo LÉ, Godin AG, De Koninck Y, Lombroso PJ, Tsai EC, Hildebrand ME., Free PMC Article | 03/14/2020 |
| validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a. | A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
Kumar P, Munnangi P, Chowdary KR, Shah VJ, Shinde SR, Kolli NR, Halehalli RR, Nagarajaram HA, Maddika S., Free PMC Article | 05/19/2018 |
| This current study demonstrated that spinal STEP61 regulated LTP of C fiber-evoked field potentials, one of the extensively studied cellular models of central sensitization. | Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats.
Suo ZW, Liu JP, Xue M, Yang YH, Yang X, Xie J, Hu XD. | 03/10/2018 |
| a dual role for PSD-95 in stabilizing synaptic NMDARs by binding directly to GluN2B but also by promoting synaptic exclusion and degradation of the negative regulator STEP61. | PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61.
Won S, Incontro S, Nicoll RA, Roche KW., Free PMC Article | 02/3/2018 |
| STEP is involved in the mechanism of depressive disorders and it is a promising molecular target for atypical antidepressant drugs of new generation. (Review) | Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders.
Kulikova E, Kulikov A. | 11/11/2017 |
| Data suggest that PP5/PTPN5 is overexpressed in liver samples from patients with hepatocellular carcinoma (HCC); overexpression of PP5/PTPN5 appears to correlate with tumor burden/stage. Inhibition of PP5/PTPN5 suppresses proliferation and promotes apoptosis of HCC cells; inhibition of PP5/PTPN5 involves activation of AMPK. | Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase.
Chen YL, Hung MH, Chu PY, Chao TI, Tsai MH, Chen LJ, Hsiao YJ, Shih CT, Hsieh FS, Chen KF. | 07/29/2017 |
| A rare missense variant in the PTPN5 gene (rs56234898; minor allele frequency 1.5%) was significantly associated with decreased severity of Post-Burn Hypertrophic Scarring(P = 1.3x10-6). | Missense Variant in MAPK Inactivator PTPN5 Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring.
Sood RF, Arbabi S, Honari S, Gibran NS., Free PMC Article | 07/30/2016 |
| STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder | STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder.
Lanz TA, Joshi JJ, Reinhart V, Johnson K, Grantham LE 2nd, Volfson D., Free PMC Article | 02/20/2016 |
| Article focuses on the most recent findings on STEP, discuss how STEP expression and activity are maintained during normal cognitive function, and how disruptions in STEP activity contribute to a number of illnesses. [Review] | Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.
Karasawa T, Lombroso PJ., Free PMC Article | 10/31/2015 |
| Decreased STEP protein activation in corpus striatum contributes to early enhanced apoptotic signaling in YAC model transgenic mice. | Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.
Gladding CM, Fan J, Zhang LY, Wang L, Xu J, Li EH, Lombroso PJ, Raymond LA., Free PMC Article | 08/30/2014 |
| This experiments demonstrated that deletion of STEP can enhance experience-induced neuroplasticity and memory formation | The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity.
Olausson P, Venkitaramani DV, Moran TD, Salter MW, Taylor JR, Lombroso PJ., Free PMC Article | 04/20/2013 |
| The results imply a model in which PTPN5 may play a role in normal cognitive functioning and contribute to aspects of the neuropathology of schizophrenia. | Involvement of PTPN5, the gene encoding the striatal-enriched protein tyrosine phosphatase, in schizophrenia and cognition.
Pelov I, Teltsh O, Greenbaum L, Rigbi A, Kanyas-Sarner K, Lerer B, Lombroso P, Kohn Y., Free PMC Article | 11/17/2012 |
| This study identified a novel role for PTPN5 in mediating the development of stress-related cognitive and morphological changes. | A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
Yang CH, Huang CC, Hsu KS., Free PMC Article | 08/11/2012 |
| STEP(61kDa) is required for Abeta transgene-mediated internalization of GluA1/GluA2 glutamate receptors in a transgenic mousemodel. | Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.
Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ., Free PMC Article | 12/3/2011 |
| STEP contributes to aspects of the pathophysiology in Alzheimer's disease; loss of GluN1/GluN2B subunits from neuronal membranes and Abeta-mediated NMDAR internalization are discussed | The role of STEP in Alzheimer's disease.
Kurup P, Zhang Y, Venkitaramani DV, Xu J, Lombroso PJ., Free PMC Article | 05/14/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| findings show that STEP(61) levels are progressively increased in the prefrontal cortex of Alzheimer disease brains | Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.
Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ., Free PMC Article | 05/31/2010 |
| in colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency | Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
Korff S, Woerner SM, Yuan YP, Bork P, von Knebel Doeberitz M, Gebert J, Korff S, Woerner SM, Yuan YP, Bork P, von Knebel Doeberitz M, Gebert J., Free PMC Articles: PMC2586028, PMC2586028 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
Korff S, Woerner SM, Yuan YP, Bork P, von Knebel Doeberitz M, Gebert J, Korff S, Woerner SM, Yuan YP, Bork P, von Knebel Doeberitz M, Gebert J., Free PMC Articles: PMC2586028, PMC2586028 | 11/26/2008 |
| determined high-resolution structures of all of the human family members of Mitogen-Activated Protein Kinase-specific protein tyrosine phosphatases | Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ., Free PMC Article | 01/21/2010 |