| RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis. | RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis.
Li H, Zhang J, Yu B, Yang T, Liu B, Li F, Jin X, Li Q. | 10/3/2024 |
| Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma. | Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma.
Wu G, Wang D, Xiong F, Liu W, Wang Q, Chen J, Wang B, Chen Y., Free PMC Article | 11/28/2023 |
| Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKalpha axis. | Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKα axis.
Ning N, Wang Q, Li J, Liu B, Chen G, Hui J, An L. | 06/15/2023 |
| Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer. | Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.
Jeong JH, Yun JW, Kim HY, Heo CY, Lee S., Free PMC Article | 10/1/2022 |
| RSPO3 is a novel contraction-inducible factor identified in an ""in vitro exercise model"" using primary human myotubes. | RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes.
Takahashi T, Li Y, Chen W, Nyasha MR, Ogawa K, Suzuki K, Koide M, Hagiwara Y, Itoi E, Aizawa T, Tsuchiya M, Suzuki N, Aoki M, Kanzaki M., Free PMC Article | 08/27/2022 |
| RSPO3 is important for trabecular bone and fracture risk in mice and humans. | RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C., Free PMC Article | 09/4/2021 |
| Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies. | Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies.
Ueland T, Estensen ME, Grindheim G, Bollerslev J, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Lekva T. | 05/22/2021 |
| R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. | R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.
Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R., Free PMC Article | 03/27/2021 |
| Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia. | Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia.
Salik B, Yi H, Hassan N, Santiappillai N, Vick B, Connerty P, Duly A, Trahair T, Woo AJ, Beck D, Liu T, Spiekermann K, Jeremias I, Wang J, Kavallaris M, Haber M, Norris MD, Liebermann DA, D'Andrea RJ, Murriel C, Wang JY. | 03/13/2021 |
| R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers. | R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.
Conboy CB, Vélez-Reyes GL, Rathe SK, Abrahante JE, Temiz NA, Burns MB, Harris RS, Starr TK, Largaespada DA., Free PMC Article | 02/6/2021 |
| RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. | RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Loh NY, Minchin JEN, Pinnick KE, Verma M, Todorčević M, Denton N, Moustafa JE, Kemp JP, Gregson CL, Evans DM, Neville MJ, Small KS, McCarthy MI, Mahajan A, Rawls JF, Karpe F, Christodoulides C., Free PMC Article | 08/22/2020 |
| RSPO3 promotes the tumor growth and progression of choriocarcinoma. | R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.
Chen Z, Zhang J, Yuan A, Han J, Tan L, Zhou Z, Zhao H, Su R, Huang B, Wang B, Sun B, Fan X, Yang Q. | 08/1/2020 |
| RSPO3 was found to be highly elevated in the active lesions of fibrotic tissues in patients with idiopathic pulmonary fibrosis and nonalcoholic steatohepatitis. | Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.
Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J, Brenner DA, Hariharan K, Cho H, Xie W., Free PMC Article | 07/11/2020 |
| RSPO3 functions as a positive prognostic marker in prostate cancer. | RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer.
Mesci A, Lucien F, Huang X, Wang EH, Shin D, Meringer M, Hoey C, Ray J, Boutros PC, Leong HS, Liu SK., Free PMC Article | 04/11/2020 |
| RSPO3 exhibited a tumor-promoting effect in bladder cancer cells through activation of Wnt/beta-catenin and Hedgehog signaling pathways. | RSPO3 promotes the aggressiveness of bladder cancer via Wnt/β-catenin and Hedgehog signaling pathways.
Chen Z, Zhou L, Chen L, Xiong M, Kazobinka G, Pang Z, Hou T. | 12/7/2019 |
| RSPO3 is produced by stromal cells in the tumor microenvironment and the activating mutations appear to sensitize the tumors to Wnt-Rspo synergy. The combination of RSPO3 inhibition and taxane treatment provides an approach to effectively target oncogenic WNT signaling | RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations.
Fischer MM, Yeung VP, Cattaruzza F, Hussein R, Yen WC, Murriel C, Evans JW, O'Young G, Brunner AL, Wang M, Cain J, Cancilla B, Kapoun A, Hoey T., Free PMC Article | 07/6/2019 |
| significant association of the RSPO3 rs7741021 SNP with the calcaneus bone density | The RSPO3 gene as genetic markers for bone mass assessed by quantitative ultrasound in a population of young adults.
Correa-Rodríguez M, Schmidt Rio-Valle J, Rueda-Medina B. | 06/29/2019 |
| Taken together, we show in this short report that the matricellular protein RSPO3 is a novel permeability factor inducing barrier dysfunction in human primary vascular endothelial monolayers of macro- and micro- vascular origin, and RSPO3 acts synergistically with the prototypic pro-inflammatory mediator IL-1beta. | RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1.
Skaria T, Bachli E, Schoedon G., Free PMC Article | 01/19/2019 |
| Knockdown of RSPO3 resulted in significantly increased mRNA expression levels of RUNX2, ALP and OCN and no effects on the proliferation of human adipose-derived stem cells. | RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling.
Zhang M, Zhang P, Liu Y, Lv L, Zhang X, Liu H, Zhou Y., Free PMC Article | 11/10/2018 |
| For liver transplant-free survival, a genome-wide significant signal was identified and expression of the candidate gene RSPO3 was demonstrated in key liver-resident effector cells and may play a role in primary sclerosing cholangitis disease progression. | Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J, Eksteen B, Ellinghaus D, Färkkilä M, Festen EAM, Floreani A, Franceschet I, Gotthardt DN, Hirschfield GM, Hoek BV, Holm K, Hohenester S, Hov JR, Imhann F, Invernizzi P, Juran BD, Lenzen H, Lieb W, Liu JZ, Marschall HU, Marzioni M, Melum E, Milkiewicz P, Müller T, Pares A, Rupp C, Rust C, Sandford RN, Schramm C, Schreiber S, Schrumpf E, Silverberg MS, Srivastava B, Sterneck M, Teufel A, Vallier L, Verheij J, Vila AV, Vries B, Zachou K, International PSC Study Group, The UK PSC Consortium, Chapman RW, Manns MP, Pinzani M, Rushbrook SM, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK., Free PMC Article | 07/28/2018 |
| The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA) and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA. | Comprehensive characterization of RSPO fusions in colorectal traditional serrated adenomas.
Sekine S, Ogawa R, Hashimoto T, Motohiro K, Yoshida H, Taniguchi H, Saito Y, Yasuhiro O, Ochiai A, Hiraoka N. | 06/16/2018 |
| RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway | RSPOs facilitated HSC activation and promoted hepatic fibrogenesis.
Yin X, Yi H, Wang L, Wu W, Wu X, Yu L., Free PMC Article | 04/7/2018 |
| Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. | Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
Picco G, Petti C, Centonze A, Torchiaro E, Crisafulli G, Novara L, Acquaviva A, Bardelli A, Medico E., Free PMC Article | 10/7/2017 |
| PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs). | Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.
Sekine S, Yamashita S, Tanabe T, Hashimoto T, Yoshida H, Taniguchi H, Kojima M, Shinmura K, Saito Y, Hiraoka N, Ushijima T, Ochiai A. | 06/3/2017 |
| Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt/beta-catenin signaling. | C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells.
Fujiwara M, Kato S, Niwa Y, Suzuki T, Tsuchiya M, Sasazawa Y, Dohmae N, Simizu S. | 05/13/2017 |